Ontology type: schema:ScholarlyArticle
1997-08
AUTHORSByeongmoon Jeong, You Han Bae, Doo Sung Lee, Sung Wan Kim
ABSTRACTPolymers that display a physicochemical response to stimuli are widely explored as potential drug-delivery systems. Stimuli studied to date include chemical substances and changes in temperature, pH and electric field. Homopolymers or copolymers of N-isopropylacrylamide and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (known as poloxamers) are typical examples of thermosensitive polymers, but their use in drug delivery is problematic because they are toxic and non-biodegradable. Biodegradable polymers used for drug delivery to date have mostly been in the form of injectable microspheres or implant systems, which require complicated fabrication processes using organic solvents. Such systems have the disadvantage that the use of organic solvents can cause denaturation when protein drugs are to be encapsulated. Furthermore, the solid form requires surgical insertion, which often results in tissue irritation and damage. Here we report the synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid). Aqueous solutions of these copolymers exhibit temperature-dependent reversible gel-sol transitions. The hydrogel can be loaded with bioactive molecules in an aqueous phase at an elevated temperature (around 45 degrees C), where they form a sol. In this form, the polymer is injectable. On subcutaneous injection and subsequent rapid cooling to body temperature, the loaded copolymer forms a gel that can act as a sustained-release matrix for drugs. More... »
PAGES860-862
http://scigraph.springernature.com/pub.10.1038/42218
DOIhttp://dx.doi.org/10.1038/42218
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1022728510
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9278046
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Macromolecular and Materials Chemistry",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biodegradation, Environmental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Delayed-Action Preparations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dextrans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Delivery Systems",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorescein-5-isothiocyanate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Injections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lactic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyesters",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polyethylene Glycols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"Biomedical Polymers Research Building, Room 205, CCCD/Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA"
],
"type": "Organization"
},
"familyName": "Jeong",
"givenName": "Byeongmoon",
"id": "sg:person.01220467343.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220467343.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"Biomedical Polymers Research Building, Room 205, CCCD/Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA"
],
"type": "Organization"
},
"familyName": "Bae",
"givenName": "You Han",
"id": "sg:person.01317224574.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317224574.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"Biomedical Polymers Research Building, Room 205, CCCD/Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Doo Sung",
"id": "sg:person.0633347701.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633347701.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Utah",
"id": "https://www.grid.ac/institutes/grid.223827.e",
"name": [
"Biomedical Polymers Research Building, Room 205, CCCD/Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Sung Wan",
"id": "sg:person.010331273234.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331273234.54"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/app.1984.070290119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002713349"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/marc.1987.030081002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022577059"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0168-3659(93)90155-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024345845"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0168-3659(93)90155-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024345845"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/373049a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033718293",
"https://doi.org/10.1038/373049a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-4636(199601)30:1<31::aid-jbm5>3.0.co;2-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036654101"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/354291a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036916751",
"https://doi.org/10.1038/354291a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/app.1990.070390101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048007820"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ja00115a039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055707963"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00046a049",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056174570"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/ma00087a009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056176789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.2218494",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062527623"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077996855",
"type": "CreativeWork"
}
],
"datePublished": "1997-08",
"datePublishedReg": "1997-08-01",
"description": "Polymers that display a physicochemical response to stimuli are widely explored as potential drug-delivery systems. Stimuli studied to date include chemical substances and changes in temperature, pH and electric field. Homopolymers or copolymers of N-isopropylacrylamide and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (known as poloxamers) are typical examples of thermosensitive polymers, but their use in drug delivery is problematic because they are toxic and non-biodegradable. Biodegradable polymers used for drug delivery to date have mostly been in the form of injectable microspheres or implant systems, which require complicated fabrication processes using organic solvents. Such systems have the disadvantage that the use of organic solvents can cause denaturation when protein drugs are to be encapsulated. Furthermore, the solid form requires surgical insertion, which often results in tissue irritation and damage. Here we report the synthesis of a thermosensitive, biodegradable hydrogel consisting of blocks of poly(ethylene oxide) and poly(L-lactic acid). Aqueous solutions of these copolymers exhibit temperature-dependent reversible gel-sol transitions. The hydrogel can be loaded with bioactive molecules in an aqueous phase at an elevated temperature (around 45 degrees C), where they form a sol. In this form, the polymer is injectable. On subcutaneous injection and subsequent rapid cooling to body temperature, the loaded copolymer forms a gel that can act as a sustained-release matrix for drugs.",
"genre": "research_article",
"id": "sg:pub.10.1038/42218",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "6645",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "388"
}
],
"name": "Biodegradable block copolymers as injectable drug-delivery systems",
"pagination": "860-862",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"6c4821738c57628a4e6bde2c26a6190833b4f9630812faa5dc86ef805579c5a6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"9278046"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/42218"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1022728510"
]
}
],
"sameAs": [
"https://doi.org/10.1038/42218",
"https://app.dimensions.ai/details/publication/pub.1022728510"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:24",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/42218"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/42218'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/42218'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/42218'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/42218'
This table displays all metadata directly associated to this object as RDF triples.
179 TRIPLES
21 PREDICATES
54 URIs
34 LITERALS
22 BLANK NODES