α-Synuclein in Lewy bodies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-08

AUTHORS

Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert

ABSTRACT

Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB)1,2,3,4, constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present5,6,7,8, but it is unclear whether they are major components of the filamentous material of the Lewy body9,10. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease11. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions. More... »

PAGES

839-840

References to SciGraph publications

  • 1976-09. Presenile dementia with Alzheimer-, Pick- and Lewy-body changes in ACTA NEUROPATHOLOGICA
  • 1988-07. Lewy bodies are ubiquitinated in ACTA NEUROPATHOLOGICA
  • Journal

    TITLE

    Nature

    ISSUE

    6645

    VOLUME

    388

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/42166

    DOI

    http://dx.doi.org/10.1038/42166

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029460877

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9278044


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