α-Synuclein in Lewy bodies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-08

AUTHORS

Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert

ABSTRACT

Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB)1,2,3,4, constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present5,6,7,8, but it is unclear whether they are major components of the filamentous material of the Lewy body9,10. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease11. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions. More... »

PAGES

839-840

References to SciGraph publications

  • 1976-09. Presenile dementia with Alzheimer-, Pick- and Lewy-body changes in ACTA NEUROPATHOLOGICA
  • 1988-07. Lewy bodies are ubiquitinated in ACTA NEUROPATHOLOGICA
  • Journal

    TITLE

    Nature

    ISSUE

    6645

    VOLUME

    388

    Related Patents

  • Pharmaceutical Composition For The Prevention Or Treatment Of Degenerative Neurological Brain Disorders
  • Prevention And Treatment Of Synucleinopathic And Amyloidogenic Disease
  • Crispr/Cas Global Regulator Screening Platform
  • Misfolded Protein Sensor Method
  • Methods Of Preventing, Treating, And Diagnosing Disorders Of Protein Aggregation
  • Compositions And Methods For Prevention And Treatment Of Neurodegenerative Diseases
  • Potent Peptide Inhibitors Of Protein Aggregation
  • Blood-Brain Barrier Shuttles Containing Antibodies Recognizing Alpha-Synuclein
  • Method Of Identifying, Diagnosing And Treating Synuclein Positive Neurodegenerative Disorders
  • Method For Treating Amyloid Disease
  • Antibodies To Alpha-Synuclein
  • Human Α Synuclein Expressing Transgenic Mice
  • Antibodies For The Treatment Of Synucleinopathy
  • Antibodies To Alpha Synuclein
  • Compositions For Prevention And Treatment Of Neurodegenerative Diseases
  • Method Of Screening For Lrrk2-Related Parkinsonism Inheritance
  • Treatment And Delay Of Onset Of Synucleinopathic And Amyloidogenic Disease
  • Method For Treating Amyloid Disease
  • Methods Of Diagnosing Parkinson's Disease
  • Misfolded Protein Sensor Method
  • Peptide Directed Protein Knockdown
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Methods And Compositions For Inhibiting Diseases Of The Central Nervous System
  • Treating Neural Disease With Tyrosine Kinase Inhibitors
  • Prevention And Treatment Of Synucleinopathic And Amyloidogenic Disease
  • Modified Antibody Fcs And Methods Of Use
  • Prevention And Treatment Of Synucleinopathic And Amyloidogenic Disease
  • Method For Screening For Anti-Amyloidogenic Properties And Method For Treatment Of Neurodegenerative Disease
  • Naturally Occurring Autoantibodies Against Alpha-Synuclein That Inhibit The Aggregation And Cytotoxicity Of Alpha-Synuclein
  • Composition And Method For Treating Neurodegenerative Disease
  • Method For Predicting Protein Aggregation And Designing Aggregation Inhibitors
  • Antibodies For The Treatment Of Synucleinopathy
  • Α-Synuclein Super-Mutants Accelerate Α-Synuclein Aggregation
  • Treatment And Delay Of Outset Of Synucleinopathic And Amyloidogenic Disease
  • Immunotherapeutic Modulation Of Amyloidogenic Disease Using Non-Fibrillogenic, Non-Amyloidogenic Polymerized Proteins And Peptides
  • Polynucleotide
  • Treating Neural Disease With Tyrosine Kinase Inhibitors
  • Antibodies To Alpha-Synuclein
  • Combination Therapies
  • Lrrk2 Polynucleotides
  • Compounds For The Treatment Of Diseases Associated With Amyloid Or Amyloid-Like Proteins
  • Method For Treating Amyloid Disease
  • Method For Preventing, Treating And Diagnosing Disorders Of Protein Aggregation
  • Peptide Directed Protein Knockdown
  • Antibodies For The Treatment Of Synucleinopathy
  • Small Molecule Activators Of Nrf2 Pathway
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Prevention And Treatment Of Synucleinopathic And Amyloidogenic Disease
  • Treatment And Delay Of Outset Of Parkinson's Disease
  • Treatment Of Proteinopathies
  • Antibodies For The Treatment Of Synucleinopathy
  • Immunization With Amyloid-Beta Oligomers
  • Methods And Compositions For Inhibiting Diseases Of The Central Nervous System
  • Methods And Compositions For Inhibiting Diseases Of The Central Nervous System
  • Monoclonal Anti-Alpha-Synuclein Antibodies For Preventing Tau Aggregation
  • Optimized Mirna Constructs
  • Methods Of Using Antibodies To Detect Alpha-Synuclein In Fluid Samples
  • Misfolded Protein Sensor Method In Body Fluids
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/42166

    DOI

    http://dx.doi.org/10.1038/42166

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029460877

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9278044


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lewy Bodies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nerve Tissue Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parkinson Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synucleins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "alpha-Synuclein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, CB2 2PY, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, CB2 2PY, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spillantini", 
            "givenName": "Maria Grazia", 
            "id": "sg:person.015203764577.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015203764577.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Marie Luise", 
            "id": "sg:person.016667142762.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016667142762.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Virginia M.-Y.", 
            "id": "sg:person.010250036517.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010250036517.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA", 
              "id": "http://www.grid.ac/institutes/grid.25879.31", 
              "name": [
                "Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trojanowski", 
            "givenName": "John Q.", 
            "id": "sg:person.01043025611.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jakes", 
            "givenName": "Ross", 
            "id": "sg:person.0762551421.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762551421.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goedert", 
            "givenName": "Michel", 
            "id": "sg:person.01266104015.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266104015.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf00685366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023557447", 
              "https://doi.org/10.1007/bf00685366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00687787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043249355", 
              "https://doi.org/10.1007/bf00687787"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1997-08", 
        "datePublishedReg": "1997-08-01", 
        "description": "Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB)1,2,3,4, constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present5,6,7,8, but it is unclear whether they are major components of the filamentous material of the Lewy body9,10. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for \u03b1-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease11. \u03b1-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for \u03b1-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/42166", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6645", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "388"
          }
        ], 
        "keywords": [
          "Lewy bodies", 
          "Parkinson's disease", 
          "idiopathic Parkinson's disease", 
          "pathological characteristics", 
          "neurofibrillary lesions", 
          "strong staining", 
          "Alzheimer's disease", 
          "disease", 
          "familial cases", 
          "cell pathology", 
          "presynaptic proteins", 
          "synuclein", 
          "filamentous material", 
          "DLB", 
          "dementia", 
          "lesions", 
          "Lewy", 
          "pathology", 
          "neurofilaments", 
          "neurodegeneration", 
          "antibodies", 
          "staining", 
          "body", 
          "major component", 
          "cases", 
          "protein", 
          "ubiquitin", 
          "biochemical composition", 
          "function", 
          "unknown function", 
          "components", 
          "main components", 
          "characteristics", 
          "formation", 
          "identical composition", 
          "materials", 
          "composition", 
          "common nerve cell pathology", 
          "nerve cell pathology", 
          "disease11"
        ], 
        "name": "\u03b1-Synuclein in Lewy bodies", 
        "pagination": "839-840", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1029460877"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/42166"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "9278044"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/42166", 
          "https://app.dimensions.ai/details/publication/pub.1029460877"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_275.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/42166"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/42166'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/42166'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/42166'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/42166'


     

    This table displays all metadata directly associated to this object as RDF triples.

    178 TRIPLES      21 PREDICATES      75 URIs      65 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/42166 schema:about N2cfbb0dc6ef747ea99f90a190d387924
    2 N4e9f061e1e2645ae9009c16e403406ea
    3 N82cf68804ab04fb1a802291dc651fbf7
    4 N8ff3c1ae601a4b8b8505f26c9a97d3c8
    5 Naa3c6288e42e4824a9b7f0f37412bc41
    6 Nd4e2ca6ce5134a64ae5239a046e7227e
    7 Nd4f2363e6d6e496190aa261976bd7520
    8 anzsrc-for:11
    9 anzsrc-for:1109
    10 schema:author N84356246d41a4e139f2112cc54fe0fe6
    11 schema:citation sg:pub.10.1007/bf00685366
    12 sg:pub.10.1007/bf00687787
    13 schema:datePublished 1997-08
    14 schema:datePublishedReg 1997-08-01
    15 schema:description Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB)1,2,3,4, constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present5,6,7,8, but it is unclear whether they are major components of the filamentous material of the Lewy body9,10. Here we describe strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease11. α-Synuclein may be the main component of the Lewy body in Parkinson's disease. We also show staining for α-synuclein of Lewy bodies from DLB, indicating that the Lewy bodies from these two diseases may have identical compositions.
    16 schema:genre article
    17 schema:isAccessibleForFree true
    18 schema:isPartOf N29ea453beee74ef88f0903d5a37926fc
    19 N94fbd4764c3d44bfae46d3bdd4f04bb6
    20 sg:journal.1018957
    21 schema:keywords Alzheimer's disease
    22 DLB
    23 Lewy
    24 Lewy bodies
    25 Parkinson's disease
    26 antibodies
    27 biochemical composition
    28 body
    29 cases
    30 cell pathology
    31 characteristics
    32 common nerve cell pathology
    33 components
    34 composition
    35 dementia
    36 disease
    37 disease11
    38 familial cases
    39 filamentous material
    40 formation
    41 function
    42 identical composition
    43 idiopathic Parkinson's disease
    44 lesions
    45 main components
    46 major component
    47 materials
    48 nerve cell pathology
    49 neurodegeneration
    50 neurofibrillary lesions
    51 neurofilaments
    52 pathological characteristics
    53 pathology
    54 presynaptic proteins
    55 protein
    56 staining
    57 strong staining
    58 synuclein
    59 ubiquitin
    60 unknown function
    61 schema:name α-Synuclein in Lewy bodies
    62 schema:pagination 839-840
    63 schema:productId N8ecb6e1e4e0a4da690ad4fb99ae30184
    64 Na9328dd68728414f9f4586bb48c15f54
    65 Nc228a3b39c3f468a83f49dfc1382ccd7
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029460877
    67 https://doi.org/10.1038/42166
    68 schema:sdDatePublished 2021-11-01T18:01
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher N67af956b0c3f4a22927139ed885eaadb
    71 schema:url https://doi.org/10.1038/42166
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N29ea453beee74ef88f0903d5a37926fc schema:volumeNumber 388
    76 rdf:type schema:PublicationVolume
    77 N29feb70613914eb98584fdf28ba647e9 rdf:first sg:person.010250036517.64
    78 rdf:rest N813ed9fca89e498383ec09c2e066795c
    79 N2cfbb0dc6ef747ea99f90a190d387924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Humans
    81 rdf:type schema:DefinedTerm
    82 N4e9f061e1e2645ae9009c16e403406ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Nerve Tissue Proteins
    84 rdf:type schema:DefinedTerm
    85 N67af956b0c3f4a22927139ed885eaadb schema:name Springer Nature - SN SciGraph project
    86 rdf:type schema:Organization
    87 N813ed9fca89e498383ec09c2e066795c rdf:first sg:person.01043025611.21
    88 rdf:rest N8d4676237dcf4331841503ea99b937aa
    89 N82cf68804ab04fb1a802291dc651fbf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Immunohistochemistry
    91 rdf:type schema:DefinedTerm
    92 N84356246d41a4e139f2112cc54fe0fe6 rdf:first sg:person.015203764577.73
    93 rdf:rest Nc7b53c019f744e6099b12845fd7e7821
    94 N8d4676237dcf4331841503ea99b937aa rdf:first sg:person.0762551421.32
    95 rdf:rest Ne4660799811a49fca394ab6a668d6820
    96 N8ecb6e1e4e0a4da690ad4fb99ae30184 schema:name doi
    97 schema:value 10.1038/42166
    98 rdf:type schema:PropertyValue
    99 N8ff3c1ae601a4b8b8505f26c9a97d3c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Parkinson Disease
    101 rdf:type schema:DefinedTerm
    102 N94fbd4764c3d44bfae46d3bdd4f04bb6 schema:issueNumber 6645
    103 rdf:type schema:PublicationIssue
    104 Na9328dd68728414f9f4586bb48c15f54 schema:name pubmed_id
    105 schema:value 9278044
    106 rdf:type schema:PropertyValue
    107 Naa3c6288e42e4824a9b7f0f37412bc41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Lewy Bodies
    109 rdf:type schema:DefinedTerm
    110 Nc228a3b39c3f468a83f49dfc1382ccd7 schema:name dimensions_id
    111 schema:value pub.1029460877
    112 rdf:type schema:PropertyValue
    113 Nc7b53c019f744e6099b12845fd7e7821 rdf:first sg:person.016667142762.78
    114 rdf:rest N29feb70613914eb98584fdf28ba647e9
    115 Nd4e2ca6ce5134a64ae5239a046e7227e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Synucleins
    117 rdf:type schema:DefinedTerm
    118 Nd4f2363e6d6e496190aa261976bd7520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name alpha-Synuclein
    120 rdf:type schema:DefinedTerm
    121 Ne4660799811a49fca394ab6a668d6820 rdf:first sg:person.01266104015.37
    122 rdf:rest rdf:nil
    123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    124 schema:name Medical and Health Sciences
    125 rdf:type schema:DefinedTerm
    126 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    127 schema:name Neurosciences
    128 rdf:type schema:DefinedTerm
    129 sg:journal.1018957 schema:issn 0028-0836
    130 1476-4687
    131 schema:name Nature
    132 schema:publisher Springer Nature
    133 rdf:type schema:Periodical
    134 sg:person.010250036517.64 schema:affiliation grid-institutes:grid.25879.31
    135 schema:familyName Lee
    136 schema:givenName Virginia M.-Y.
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010250036517.64
    138 rdf:type schema:Person
    139 sg:person.01043025611.21 schema:affiliation grid-institutes:grid.25879.31
    140 schema:familyName Trojanowski
    141 schema:givenName John Q.
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043025611.21
    143 rdf:type schema:Person
    144 sg:person.01266104015.37 schema:affiliation grid-institutes:grid.42475.30
    145 schema:familyName Goedert
    146 schema:givenName Michel
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266104015.37
    148 rdf:type schema:Person
    149 sg:person.015203764577.73 schema:affiliation grid-institutes:grid.5335.0
    150 schema:familyName Spillantini
    151 schema:givenName Maria Grazia
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015203764577.73
    153 rdf:type schema:Person
    154 sg:person.016667142762.78 schema:affiliation grid-institutes:grid.25879.31
    155 schema:familyName Schmidt
    156 schema:givenName Marie Luise
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016667142762.78
    158 rdf:type schema:Person
    159 sg:person.0762551421.32 schema:affiliation grid-institutes:grid.42475.30
    160 schema:familyName Jakes
    161 schema:givenName Ross
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762551421.32
    163 rdf:type schema:Person
    164 sg:pub.10.1007/bf00685366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023557447
    165 https://doi.org/10.1007/bf00685366
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/bf00687787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043249355
    168 https://doi.org/10.1007/bf00687787
    169 rdf:type schema:CreativeWork
    170 grid-institutes:grid.25879.31 schema:alternateName Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA
    171 schema:name Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104-4283, Philadelphia, Pennsylvania, USA
    172 rdf:type schema:Organization
    173 grid-institutes:grid.42475.30 schema:alternateName Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    174 schema:name Medical Research Council Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    175 rdf:type schema:Organization
    176 grid-institutes:grid.5335.0 schema:alternateName Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, CB2 2PY, Cambridge, UK
    177 schema:name Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, CB2 2PY, Cambridge, UK
    178 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...