Gene expression: RNA interference in adult mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-07

AUTHORS

Anton P McCaffrey, Leonard Meuse, Thu-Thao T Pham, Douglas S Conklin, Gregory J Hannon, Mark A Kay

ABSTRACT

RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo. More... »

PAGES

38-39

Journal

TITLE

Nature

ISSUE

6893

VOLUME

418

Author Affiliations

From Grant

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  • Identifiers

    URI

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    DOI

    http://dx.doi.org/10.1038/418038a

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006471802

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12097900


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