BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M. Adams, Andreas Strasser

ABSTRACT

During lymphocyte development, the assembly of genes coding for antigen receptors occurs by the combinatorial linking of gene segments. The stochastic nature of this process gives rise to lymphocytes that can recognize self-antigens, thereby having the potential to induce autoimmune disease. Such autoreactive lymphocytes can be silenced by developmental arrest or unresponsiveness (anergy)1, or can be deleted from the repertoire by cell death1. In the thymus, developing T lymphocytes (thymocytes) bearing a T-cell receptor (TCR)–CD3 complex that engages self-antigens are induced to undergo programmed cell death (apoptosis)2,3,4, but the mechanisms ensuring this ‘negative selection’ are unclear. We now report that thymocytes lacking the pro-apoptotic Bcl-2 family member Bim5,6 (also known as Bcl2l11) are refractory to apoptosis induced by TCR–CD3 stimulation. Moreover, in transgenic mice expressing autoreactive TCRs that provoke widespread deletion, Bim deficiency severely impaired thymocyte killing. TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection. More... »

PAGES

922-926

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/415922a

DOI

http://dx.doi.org/10.1038/415922a

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040375797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11859372


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis Regulatory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bcl-2-Like Protein 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-bcl-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor-CD3 Complex, Antigen, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Self Tolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superantigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouillet", 
        "givenName": "Philippe", 
        "id": "sg:person.01326401410.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326401410.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Purton", 
        "givenName": "Jared F.", 
        "id": "sg:person.01064451705.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064451705.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godfrey", 
        "givenName": "Dale I.", 
        "id": "sg:person.01161441677.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161441677.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Li-Chen", 
        "id": "sg:person.0612143361.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612143361.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coultas", 
        "givenName": "Leigh", 
        "id": "sg:person.01125006176.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125006176.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puthalakath", 
        "givenName": "Hamsa", 
        "id": "sg:person.01260266210.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260266210.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellegrini", 
        "givenName": "Marc", 
        "id": "sg:person.0677366162.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677366162.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cory", 
        "givenName": "Suzanne", 
        "id": "sg:person.01343253602.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343253602.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "Jerry M.", 
        "id": "sg:person.014441722212.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014441722212.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strasser", 
        "givenName": "Andreas", 
        "id": "sg:person.01215767043.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767043.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/372100a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035391816", 
          "https://doi.org/10.1038/372100a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351150a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023047608", 
          "https://doi.org/10.1038/351150a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-02", 
    "datePublishedReg": "2002-02-01", 
    "description": "During lymphocyte development, the assembly of genes coding for antigen receptors occurs by the combinatorial linking of gene segments. The stochastic nature of this process gives rise to lymphocytes that can recognize self-antigens, thereby having the potential to induce autoimmune disease. Such autoreactive lymphocytes can be silenced by developmental arrest or unresponsiveness (anergy)1, or can be deleted from the repertoire by cell death1. In the thymus, developing T lymphocytes (thymocytes) bearing a T-cell receptor (TCR)\u2013CD3 complex that engages self-antigens are induced to undergo programmed cell death (apoptosis)2,3,4, but the mechanisms ensuring this \u2018negative selection\u2019 are unclear. We now report that thymocytes lacking the pro-apoptotic Bcl-2 family member Bim5,6 (also known as Bcl2l11) are refractory to apoptosis induced by TCR\u2013CD3 stimulation. Moreover, in transgenic mice expressing autoreactive TCRs that provoke widespread deletion, Bim deficiency severely impaired thymocyte killing. TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/415922a", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6874", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "415"
      }
    ], 
    "keywords": [
      "T cell receptor", 
      "thymocyte negative selection", 
      "autoreactive lymphocytes", 
      "autoimmune diseases", 
      "T lymphocytes", 
      "autoreactive TCR", 
      "Bcl-2 family member Bim", 
      "transgenic mice", 
      "thymocyte killing", 
      "widespread deletion", 
      "antigen receptor", 
      "lymphocytes", 
      "lymphocyte development", 
      "autoreactive thymocytes", 
      "TCR-CD3 stimulation", 
      "CD3 complex", 
      "Bim expression", 
      "cell death", 
      "apoptosis", 
      "family members", 
      "Bim deficiency", 
      "receptors", 
      "thymocytes", 
      "Bcl-xL", 
      "essential initiator", 
      "Bcl-2 family members", 
      "pro-apoptotic Bcl-2 family members", 
      "negative selection", 
      "gene segments", 
      "Programmed Cell Death", 
      "unresponsiveness", 
      "developmental arrest", 
      "disease", 
      "thymus", 
      "mice", 
      "death", 
      "stimulation", 
      "arrest", 
      "TCR", 
      "survival function", 
      "deficiency", 
      "killing", 
      "expression", 
      "findings", 
      "interaction of Bim", 
      "death1", 
      "deletion", 
      "genes", 
      "repertoire", 
      "segments", 
      "mechanism", 
      "function", 
      "members", 
      "development", 
      "BIM", 
      "selection", 
      "potential", 
      "CELL DEATH1", 
      "BH3", 
      "rise", 
      "interaction", 
      "complexes", 
      "nature", 
      "process", 
      "initiator", 
      "assembly of genes", 
      "assembly", 
      "linking", 
      "stochastic nature"
    ], 
    "name": "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes", 
    "pagination": "922-926", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040375797"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/415922a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11859372"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/415922a", 
      "https://app.dimensions.ai/details/publication/pub.1040375797"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_357.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/415922a"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/415922a'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/415922a'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/415922a'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/415922a'


 

This table displays all metadata directly associated to this object as RDF triples.

316 TRIPLES      21 PREDICATES      125 URIs      115 LITERALS      35 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/415922a schema:about N021b102281af4b09afe93441273d3dce
2 N040fb10cd8604d699a83273f631f0f6d
3 N068618844df44d20823debe72ed6254b
4 N20238422d8d54c5581ff5ffb1843ec72
5 N242660ca217748fca26984e5bc96fb25
6 N325543e1df22487aba0e804d0eda5247
7 N3e6789f2bfa249ebb50056bff7f09567
8 N51c35e58000e495b87ce9ddfd21056c8
9 N548a4f7fc1ca49e797e9b5ba50ebe5dc
10 N5623bc4a96a342c8aed8b52b38af7886
11 N56a9e04b7a0c4881ae43700289cdc0f2
12 N5966ba1768234107a6988b63cdada106
13 N639d0ab55f354d05a6aac5f9193897dc
14 N74226a2529de4c4ea204bf55f3ee6e0a
15 N88edf97d8b494673a3183756a56c89d0
16 Na59583fc6532475b96ba3567bedcb69c
17 Nb882e57e5b5442aba24dcc16dfef8042
18 Nc46ecd8cb3dc4edc8ef5a616104274b2
19 Nc4712978646f4a849684f3cd7b4aa4e0
20 Ncb4cfc9570ae4903b197cd25c4c963a6
21 Nee412c2cd3ea4fd0ade89c2fbfdc24bc
22 Neef2cc55282d43e1a2ef46094d8e0f98
23 Nf0d764f1df044eb98a5201de61d3840b
24 Nf1658b18ad15499db1fe16871ce75d23
25 Nf22befaa5bd344bda6e3c0bcd25bce11
26 Nf399a030e16d4eb5b95d282b263cb363
27 Nf40a4e620e3a4f8c8c6aac6efa04974a
28 Nf8dd3d5b38a94f08aeb2a4a90cd2ac35
29 anzsrc-for:11
30 anzsrc-for:1107
31 schema:author N4e9233ee5b3743e4b14e546190e1e53e
32 schema:citation sg:pub.10.1038/351150a0
33 sg:pub.10.1038/372100a0
34 schema:datePublished 2002-02
35 schema:datePublishedReg 2002-02-01
36 schema:description During lymphocyte development, the assembly of genes coding for antigen receptors occurs by the combinatorial linking of gene segments. The stochastic nature of this process gives rise to lymphocytes that can recognize self-antigens, thereby having the potential to induce autoimmune disease. Such autoreactive lymphocytes can be silenced by developmental arrest or unresponsiveness (anergy)1, or can be deleted from the repertoire by cell death1. In the thymus, developing T lymphocytes (thymocytes) bearing a T-cell receptor (TCR)–CD3 complex that engages self-antigens are induced to undergo programmed cell death (apoptosis)2,3,4, but the mechanisms ensuring this ‘negative selection’ are unclear. We now report that thymocytes lacking the pro-apoptotic Bcl-2 family member Bim5,6 (also known as Bcl2l11) are refractory to apoptosis induced by TCR–CD3 stimulation. Moreover, in transgenic mice expressing autoreactive TCRs that provoke widespread deletion, Bim deficiency severely impaired thymocyte killing. TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection.
37 schema:genre article
38 schema:isAccessibleForFree false
39 schema:isPartOf N4ab7062a798b4ffeb0fcec0cff1e7f46
40 N56922c84f3f240208a2d41d068da143f
41 sg:journal.1018957
42 schema:keywords BH3
43 BIM
44 Bcl-2 family member Bim
45 Bcl-2 family members
46 Bcl-xL
47 Bim deficiency
48 Bim expression
49 CD3 complex
50 CELL DEATH1
51 Programmed Cell Death
52 T cell receptor
53 T lymphocytes
54 TCR
55 TCR-CD3 stimulation
56 antigen receptor
57 apoptosis
58 arrest
59 assembly
60 assembly of genes
61 autoimmune diseases
62 autoreactive TCR
63 autoreactive lymphocytes
64 autoreactive thymocytes
65 cell death
66 complexes
67 death
68 death1
69 deficiency
70 deletion
71 development
72 developmental arrest
73 disease
74 essential initiator
75 expression
76 family members
77 findings
78 function
79 gene segments
80 genes
81 initiator
82 interaction
83 interaction of Bim
84 killing
85 linking
86 lymphocyte development
87 lymphocytes
88 mechanism
89 members
90 mice
91 nature
92 negative selection
93 potential
94 pro-apoptotic Bcl-2 family members
95 process
96 receptors
97 repertoire
98 rise
99 segments
100 selection
101 stimulation
102 stochastic nature
103 survival function
104 thymocyte killing
105 thymocyte negative selection
106 thymocytes
107 thymus
108 transgenic mice
109 unresponsiveness
110 widespread deletion
111 schema:name BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
112 schema:pagination 922-926
113 schema:productId N19a671fe8290413b9f6c329fd35bd009
114 N59f6c4064a73473ab4fee6716dafc44b
115 Nd82c3a644c8949cc93b3153c3c5903ca
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040375797
117 https://doi.org/10.1038/415922a
118 schema:sdDatePublished 2022-12-01T06:23
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher N5b7ee34eb9c04c8abfb13e6f3169e2cc
121 schema:url https://doi.org/10.1038/415922a
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N00eb683a48364d6a9f346d867a7fc509 rdf:first sg:person.01161441677.12
126 rdf:rest Nf94ca10d3e4b4500b38dfcc80ff39177
127 N021b102281af4b09afe93441273d3dce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Mice, Transgenic
129 rdf:type schema:DefinedTerm
130 N040fb10cd8604d699a83273f631f0f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 N068618844df44d20823debe72ed6254b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Bcl-2-Like Protein 11
135 rdf:type schema:DefinedTerm
136 N0ffe8603d95e4788ab0ac66360ae2d80 rdf:first sg:person.0677366162.05
137 rdf:rest Ne71c746031c34009b9042e2d9cef8631
138 N19a671fe8290413b9f6c329fd35bd009 schema:name doi
139 schema:value 10.1038/415922a
140 rdf:type schema:PropertyValue
141 N20238422d8d54c5581ff5ffb1843ec72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Thymus Gland
143 rdf:type schema:DefinedTerm
144 N242660ca217748fca26984e5bc96fb25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Protein Transport
146 rdf:type schema:DefinedTerm
147 N2dc0c379f9bc48d4b9c231259302ebf6 rdf:first sg:person.01260266210.29
148 rdf:rest N0ffe8603d95e4788ab0ac66360ae2d80
149 N325543e1df22487aba0e804d0eda5247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Receptor-CD3 Complex, Antigen, T-Cell
151 rdf:type schema:DefinedTerm
152 N3e6789f2bfa249ebb50056bff7f09567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Carrier Proteins
154 rdf:type schema:DefinedTerm
155 N468e3dcc1fee489ca7ec981c4339d58f rdf:first sg:person.014441722212.92
156 rdf:rest N576ef03be0ae4db3a359c3c02bab1ba8
157 N4ab7062a798b4ffeb0fcec0cff1e7f46 schema:issueNumber 6874
158 rdf:type schema:PublicationIssue
159 N4e9233ee5b3743e4b14e546190e1e53e rdf:first sg:person.01326401410.55
160 rdf:rest Nb5b7fd056bb445d8a52ab467e0c3b46f
161 N51c35e58000e495b87ce9ddfd21056c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Leukopoiesis
163 rdf:type schema:DefinedTerm
164 N548a4f7fc1ca49e797e9b5ba50ebe5dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 N5623bc4a96a342c8aed8b52b38af7886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Membrane Proteins
169 rdf:type schema:DefinedTerm
170 N56922c84f3f240208a2d41d068da143f schema:volumeNumber 415
171 rdf:type schema:PublicationVolume
172 N56a9e04b7a0c4881ae43700289cdc0f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name CD4 Antigens
174 rdf:type schema:DefinedTerm
175 N576ef03be0ae4db3a359c3c02bab1ba8 rdf:first sg:person.01215767043.67
176 rdf:rest rdf:nil
177 N5966ba1768234107a6988b63cdada106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mice
179 rdf:type schema:DefinedTerm
180 N59f6c4064a73473ab4fee6716dafc44b schema:name dimensions_id
181 schema:value pub.1040375797
182 rdf:type schema:PropertyValue
183 N5b7ee34eb9c04c8abfb13e6f3169e2cc schema:name Springer Nature - SN SciGraph project
184 rdf:type schema:Organization
185 N639d0ab55f354d05a6aac5f9193897dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Staphylococcus
187 rdf:type schema:DefinedTerm
188 N74226a2529de4c4ea204bf55f3ee6e0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Molecular Sequence Data
190 rdf:type schema:DefinedTerm
191 N82018731574d4a7ba1838dc35cbb03b1 rdf:first sg:person.01125006176.31
192 rdf:rest N2dc0c379f9bc48d4b9c231259302ebf6
193 N88edf97d8b494673a3183756a56c89d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Cells, Cultured
195 rdf:type schema:DefinedTerm
196 Na59583fc6532475b96ba3567bedcb69c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Apoptosis
198 rdf:type schema:DefinedTerm
199 Nb5b7fd056bb445d8a52ab467e0c3b46f rdf:first sg:person.01064451705.21
200 rdf:rest N00eb683a48364d6a9f346d867a7fc509
201 Nb882e57e5b5442aba24dcc16dfef8042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Self Tolerance
203 rdf:type schema:DefinedTerm
204 Nc46ecd8cb3dc4edc8ef5a616104274b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name bcl-X Protein
206 rdf:type schema:DefinedTerm
207 Nc4712978646f4a849684f3cd7b4aa4e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name T-Lymphocytes
209 rdf:type schema:DefinedTerm
210 Ncb4cfc9570ae4903b197cd25c4c963a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Male
212 rdf:type schema:DefinedTerm
213 Nd82c3a644c8949cc93b3153c3c5903ca schema:name pubmed_id
214 schema:value 11859372
215 rdf:type schema:PropertyValue
216 Ne71c746031c34009b9042e2d9cef8631 rdf:first sg:person.01343253602.05
217 rdf:rest N468e3dcc1fee489ca7ec981c4339d58f
218 Nee412c2cd3ea4fd0ade89c2fbfdc24bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Mice, Inbred C57BL
220 rdf:type schema:DefinedTerm
221 Neef2cc55282d43e1a2ef46094d8e0f98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Proto-Oncogene Proteins
223 rdf:type schema:DefinedTerm
224 Nf0d764f1df044eb98a5201de61d3840b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Proto-Oncogene Proteins c-bcl-2
226 rdf:type schema:DefinedTerm
227 Nf1658b18ad15499db1fe16871ce75d23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Amino Acid Sequence
229 rdf:type schema:DefinedTerm
230 Nf22befaa5bd344bda6e3c0bcd25bce11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Superantigens
232 rdf:type schema:DefinedTerm
233 Nf399a030e16d4eb5b95d282b263cb363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name CD8 Antigens
235 rdf:type schema:DefinedTerm
236 Nf40a4e620e3a4f8c8c6aac6efa04974a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Enterotoxins
238 rdf:type schema:DefinedTerm
239 Nf8dd3d5b38a94f08aeb2a4a90cd2ac35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Apoptosis Regulatory Proteins
241 rdf:type schema:DefinedTerm
242 Nf94ca10d3e4b4500b38dfcc80ff39177 rdf:first sg:person.0612143361.01
243 rdf:rest N82018731574d4a7ba1838dc35cbb03b1
244 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
245 schema:name Medical and Health Sciences
246 rdf:type schema:DefinedTerm
247 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
248 schema:name Immunology
249 rdf:type schema:DefinedTerm
250 sg:journal.1018957 schema:issn 0028-0836
251 1476-4687
252 schema:name Nature
253 schema:publisher Springer Nature
254 rdf:type schema:Periodical
255 sg:person.01064451705.21 schema:affiliation grid-institutes:grid.1002.3
256 schema:familyName Purton
257 schema:givenName Jared F.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064451705.21
259 rdf:type schema:Person
260 sg:person.01125006176.31 schema:affiliation grid-institutes:grid.1042.7
261 schema:familyName Coultas
262 schema:givenName Leigh
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125006176.31
264 rdf:type schema:Person
265 sg:person.01161441677.12 schema:affiliation grid-institutes:grid.1002.3
266 schema:familyName Godfrey
267 schema:givenName Dale I.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161441677.12
269 rdf:type schema:Person
270 sg:person.01215767043.67 schema:affiliation grid-institutes:grid.1042.7
271 schema:familyName Strasser
272 schema:givenName Andreas
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767043.67
274 rdf:type schema:Person
275 sg:person.01260266210.29 schema:affiliation grid-institutes:grid.1042.7
276 schema:familyName Puthalakath
277 schema:givenName Hamsa
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260266210.29
279 rdf:type schema:Person
280 sg:person.01326401410.55 schema:affiliation grid-institutes:grid.1042.7
281 schema:familyName Bouillet
282 schema:givenName Philippe
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326401410.55
284 rdf:type schema:Person
285 sg:person.01343253602.05 schema:affiliation grid-institutes:grid.1042.7
286 schema:familyName Cory
287 schema:givenName Suzanne
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343253602.05
289 rdf:type schema:Person
290 sg:person.014441722212.92 schema:affiliation grid-institutes:grid.1042.7
291 schema:familyName Adams
292 schema:givenName Jerry M.
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014441722212.92
294 rdf:type schema:Person
295 sg:person.0612143361.01 schema:affiliation grid-institutes:grid.1042.7
296 schema:familyName Zhang
297 schema:givenName Li-Chen
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612143361.01
299 rdf:type schema:Person
300 sg:person.0677366162.05 schema:affiliation grid-institutes:grid.1042.7
301 schema:familyName Pellegrini
302 schema:givenName Marc
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677366162.05
304 rdf:type schema:Person
305 sg:pub.10.1038/351150a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023047608
306 https://doi.org/10.1038/351150a0
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/372100a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035391816
309 https://doi.org/10.1038/372100a0
310 rdf:type schema:CreativeWork
311 grid-institutes:grid.1002.3 schema:alternateName Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia
312 schema:name Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181, Prahran, Victoria, Australia
313 rdf:type schema:Organization
314 grid-institutes:grid.1042.7 schema:alternateName The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia
315 schema:name The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. The Royal Melbourne Hospital, 3050, Victoria, Australia
316 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...