X-linked IAP is a direct inhibitor of cell-death proteases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

Quinn L. Deveraux, Ryosuke Takahashi, Guy S. Salvesen, John C. Reed

ABSTRACT

The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to humans. Ectopic expression of human IAP proteins can suppress cell death induced by a variety of stimuli, but the mechanism of this inhibition was previously unknown. Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. As the caspases are highly conserved throughout the animal kingdom and are the principal effectors of apoptosis, our findings suggest how IAPs might inhibit cell death, providing evidence for a mechanism of action for these mammalian cell-death suppressors. More... »

PAGES

300-304

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6639

VOLUME

388

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/40901

    DOI

    http://dx.doi.org/10.1038/40901

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015400453

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9230442


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