Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-12

AUTHORS

W W Hancock, R Buelow, M H Sayegh, L A Turka

ABSTRACT

We investigated the pathogenesis of chronic allograft rejection in mouse cardiac allografts. Long-term survival occurred after administration of monoclonal antibody to CD4 or CD40-ligand (CD40L) plus donor cells. Both treatments induced permanent graft survival, but, in contrast to transplants in mice treated with CD4 monoclonal antibody, grafts in mice treated with CD40L monoclonal antibody lacked evidence of chronic rejection, including transplant arteriosclerosis. Freedom from chronic rejection in the group treated with CD40L monoclonal antibody correlated with vascular expression of the 'protective' genes heme oxygenase-1 (HO-1), Bcl-xL and A20. Moreover, arteriosclerosis was induced in allografts in immunoglobulin-deficient mice by antibody transfer only when the transfer was done before expression of protective genes. A direct role for protective gene expression in endothelial cells was demonstrated by in vitro experiments in which induction of HO-1 or Bcl-xL suppressed alloantibody-stimulated endothelial activation. Finally, induction of HO-1 in vivo protected allografts against chronic injury. These data show a role for protective genes in the prevention of chronic rejection, and indicate new approaches to protect grafts against development of transplant arteriosclerosis. More... »

PAGES

1392-1396

Journal

TITLE

Nature Medicine

ISSUE

12

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/3982

DOI

http://dx.doi.org/10.1038/3982

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031385634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9846576


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arteriosclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD40 Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft Rejection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heme Oxygenase (Decyclizing)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heme Oxygenase-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred CBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. Wayne_Hancock@Leukosite.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hancock", 
        "givenName": "W W", 
        "id": "sg:person.016436741077.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016436741077.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Buelow", 
        "givenName": "R", 
        "id": "sg:person.01150335627.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150335627.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sayegh", 
        "givenName": "M H", 
        "id": "sg:person.014630537777.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014630537777.87"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Turka", 
        "givenName": "L A", 
        "id": "sg:person.01315400021.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315400021.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm0196-87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001424949", 
          "https://doi.org/10.1038/nm0196-87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(97)01129-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004631834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.1.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008630415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4644(19980101)68:1<121::aid-jcb12>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010776290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199559040-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018175106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199559040-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018175106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.181.5.1869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026977323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/381434a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027764557", 
          "https://doi.org/10.1038/381434a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199309000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199309000-00028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034508845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0297-196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034700267", 
          "https://doi.org/10.1038/nm0297-196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.24.13967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040275345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199559040-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047216657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199559040-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047216657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0997-944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049258766", 
          "https://doi.org/10.1038/nm0997-944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199601150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199601150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199601150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199707150-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199707150-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199707150-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199712150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060277022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199712150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060277022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199712150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060277022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199805131-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060277317"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-12", 
    "datePublishedReg": "1998-12-01", 
    "description": "We investigated the pathogenesis of chronic allograft rejection in mouse cardiac allografts. Long-term survival occurred after administration of monoclonal antibody to CD4 or CD40-ligand (CD40L) plus donor cells. Both treatments induced permanent graft survival, but, in contrast to transplants in mice treated with CD4 monoclonal antibody, grafts in mice treated with CD40L monoclonal antibody lacked evidence of chronic rejection, including transplant arteriosclerosis. Freedom from chronic rejection in the group treated with CD40L monoclonal antibody correlated with vascular expression of the 'protective' genes heme oxygenase-1 (HO-1), Bcl-xL and A20. Moreover, arteriosclerosis was induced in allografts in immunoglobulin-deficient mice by antibody transfer only when the transfer was done before expression of protective genes. A direct role for protective gene expression in endothelial cells was demonstrated by in vitro experiments in which induction of HO-1 or Bcl-xL suppressed alloantibody-stimulated endothelial activation. Finally, induction of HO-1 in vivo protected allografts against chronic injury. These data show a role for protective genes in the prevention of chronic rejection, and indicate new approaches to protect grafts against development of transplant arteriosclerosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/3982", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2453232", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2434998", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Antibody-induced transplant arteriosclerosis is prevented by graft expression\nof anti-oxidant and anti-apoptotic genes", 
    "pagination": "1392-1396", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9583db79e864e0a6aa0582464c8a34fc2bdebb20e2c5800c61e8c48576deb6fd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9846576"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/3982"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031385634"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/3982", 
      "https://app.dimensions.ai/details/publication/pub.1031385634"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70028_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nm/journal/v4/n12/full/nm1298_1392.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/3982'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/3982'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/3982'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/3982'


 

This table displays all metadata directly associated to this object as RDF triples.

218 TRIPLES      21 PREDICATES      64 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/3982 schema:about N04d95eb609f44442a4e0a908e8f0719e
2 N0a57aa887ca54c36ad7d6f3cdcf18e18
3 N12818d5a7b6647ee8f7132262d2cec1b
4 N1a89226008ea43b99d022117c47706e7
5 N3952e827248548f5aa6316ee70cf2114
6 N3b7a7373da1543259ae3dec227816535
7 N3d4529f5dda44b2eb89f0dad10bf7d0c
8 N50736689f6564043be51f486aa846272
9 N65cb54f373c14c4893f3917985ae695b
10 N6bd6ac2947f0491e9bf8d3df604890e3
11 N867d2617ec0147bd9315b5b7e5f5b2cf
12 N8b8fb08e574b413980fe88a4d97eaa85
13 N9e64bd75235942f09f4b9ead62543c40
14 N9fef90dc0447445a817db8e0ce79d680
15 Nad975fc17a91473db001cb793c52d7e6
16 Nd587aa7952494deba48fea76e6894209
17 Nde4de2d1123e498a8dd5daa3324fc4f5
18 Neaf6203c48b84602b916388ea2453182
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author Ne064ccd1bd43449e80928e3c89e462e7
22 schema:citation sg:pub.10.1038/381434a0
23 sg:pub.10.1038/nm0196-87
24 sg:pub.10.1038/nm0297-196
25 sg:pub.10.1038/nm0997-944
26 https://doi.org/10.1002/(sici)1097-4644(19980101)68:1<121::aid-jcb12>3.0.co;2-k
27 https://doi.org/10.1016/s0167-5699(97)01129-8
28 https://doi.org/10.1073/pnas.93.24.13967
29 https://doi.org/10.1083/jcb.134.1.13
30 https://doi.org/10.1084/jem.181.5.1869
31 https://doi.org/10.1097/00007890-199309000-00028
32 https://doi.org/10.1097/00007890-199559040-00021
33 https://doi.org/10.1097/00007890-199559040-00023
34 https://doi.org/10.1097/00007890-199601150-00002
35 https://doi.org/10.1097/00007890-199707150-00004
36 https://doi.org/10.1097/00007890-199712150-00005
37 https://doi.org/10.1097/00007890-199805131-00002
38 https://doi.org/10.1172/jci118483
39 schema:datePublished 1998-12
40 schema:datePublishedReg 1998-12-01
41 schema:description We investigated the pathogenesis of chronic allograft rejection in mouse cardiac allografts. Long-term survival occurred after administration of monoclonal antibody to CD4 or CD40-ligand (CD40L) plus donor cells. Both treatments induced permanent graft survival, but, in contrast to transplants in mice treated with CD4 monoclonal antibody, grafts in mice treated with CD40L monoclonal antibody lacked evidence of chronic rejection, including transplant arteriosclerosis. Freedom from chronic rejection in the group treated with CD40L monoclonal antibody correlated with vascular expression of the 'protective' genes heme oxygenase-1 (HO-1), Bcl-xL and A20. Moreover, arteriosclerosis was induced in allografts in immunoglobulin-deficient mice by antibody transfer only when the transfer was done before expression of protective genes. A direct role for protective gene expression in endothelial cells was demonstrated by in vitro experiments in which induction of HO-1 or Bcl-xL suppressed alloantibody-stimulated endothelial activation. Finally, induction of HO-1 in vivo protected allografts against chronic injury. These data show a role for protective genes in the prevention of chronic rejection, and indicate new approaches to protect grafts against development of transplant arteriosclerosis.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N4cf77ded12b3411b8793ff02338bcc4a
46 Nee043cfb5cf24610bf8008bd1804075c
47 sg:journal.1113716
48 schema:name Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
49 schema:pagination 1392-1396
50 schema:productId N1d6b075094c64b168dc52a0c43f9e25e
51 N31e0ad0591854bcd8e506bbfe727759f
52 N66c2116c05fd41f5a835c6f3fe895fec
53 N729b10bf07724a7d97f16adcb1f709c6
54 Nf9eff07148fb45e9bec83afd000c0180
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031385634
56 https://doi.org/10.1038/3982
57 schema:sdDatePublished 2019-04-11T12:35
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N0e5c043b1eb94be4accc3f64f9e8c025
60 schema:url http://www.nature.com/nm/journal/v4/n12/full/nm1298_1392.html
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N04d95eb609f44442a4e0a908e8f0719e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Membrane Proteins
66 rdf:type schema:DefinedTerm
67 N0a57aa887ca54c36ad7d6f3cdcf18e18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Mice
69 rdf:type schema:DefinedTerm
70 N0e5c043b1eb94be4accc3f64f9e8c025 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N12818d5a7b6647ee8f7132262d2cec1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Antioxidants
74 rdf:type schema:DefinedTerm
75 N1a89226008ea43b99d022117c47706e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Graft Rejection
77 rdf:type schema:DefinedTerm
78 N1d6b075094c64b168dc52a0c43f9e25e schema:name pubmed_id
79 schema:value 9846576
80 rdf:type schema:PropertyValue
81 N31e0ad0591854bcd8e506bbfe727759f schema:name dimensions_id
82 schema:value pub.1031385634
83 rdf:type schema:PropertyValue
84 N3952e827248548f5aa6316ee70cf2114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice, Knockout
86 rdf:type schema:DefinedTerm
87 N3b7a7373da1543259ae3dec227816535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Cells, Cultured
89 rdf:type schema:DefinedTerm
90 N3d4529f5dda44b2eb89f0dad10bf7d0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Mice, Inbred BALB C
92 rdf:type schema:DefinedTerm
93 N4cf77ded12b3411b8793ff02338bcc4a schema:volumeNumber 4
94 rdf:type schema:PublicationVolume
95 N50736689f6564043be51f486aa846272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Mice, Inbred CBA
97 rdf:type schema:DefinedTerm
98 N65cb54f373c14c4893f3917985ae695b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Endothelium, Vascular
100 rdf:type schema:DefinedTerm
101 N66c2116c05fd41f5a835c6f3fe895fec schema:name readcube_id
102 schema:value 9583db79e864e0a6aa0582464c8a34fc2bdebb20e2c5800c61e8c48576deb6fd
103 rdf:type schema:PropertyValue
104 N6bd6ac2947f0491e9bf8d3df604890e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Animals
106 rdf:type schema:DefinedTerm
107 N729b10bf07724a7d97f16adcb1f709c6 schema:name doi
108 schema:value 10.1038/3982
109 rdf:type schema:PropertyValue
110 N867d2617ec0147bd9315b5b7e5f5b2cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name CD40 Ligand
112 rdf:type schema:DefinedTerm
113 N8b8fb08e574b413980fe88a4d97eaa85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Heme Oxygenase-1
115 rdf:type schema:DefinedTerm
116 N8e37bef8ab83432ca1bf9bfa7322d0ec rdf:first sg:person.01315400021.90
117 rdf:rest rdf:nil
118 N8f2f75bcd1214ae2a2faf5d758938da1 rdf:first sg:person.014630537777.87
119 rdf:rest N8e37bef8ab83432ca1bf9bfa7322d0ec
120 N99fb47ec7c1d48bfa7cd495550c30707 rdf:first sg:person.01150335627.93
121 rdf:rest N8f2f75bcd1214ae2a2faf5d758938da1
122 N9e64bd75235942f09f4b9ead62543c40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Heart Transplantation
124 rdf:type schema:DefinedTerm
125 N9fef90dc0447445a817db8e0ce79d680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Membrane Glycoproteins
127 rdf:type schema:DefinedTerm
128 Nad975fc17a91473db001cb793c52d7e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Arteriosclerosis
130 rdf:type schema:DefinedTerm
131 Nd587aa7952494deba48fea76e6894209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice, Inbred C57BL
133 rdf:type schema:DefinedTerm
134 Nde4de2d1123e498a8dd5daa3324fc4f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Heme Oxygenase (Decyclizing)
136 rdf:type schema:DefinedTerm
137 Ne064ccd1bd43449e80928e3c89e462e7 rdf:first sg:person.016436741077.30
138 rdf:rest N99fb47ec7c1d48bfa7cd495550c30707
139 Neaf6203c48b84602b916388ea2453182 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Apoptosis
141 rdf:type schema:DefinedTerm
142 Nee043cfb5cf24610bf8008bd1804075c schema:issueNumber 12
143 rdf:type schema:PublicationIssue
144 Nf9eff07148fb45e9bec83afd000c0180 schema:name nlm_unique_id
145 schema:value 9502015
146 rdf:type schema:PropertyValue
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
151 schema:name Immunology
152 rdf:type schema:DefinedTerm
153 sg:grant.2434998 http://pending.schema.org/fundedItem sg:pub.10.1038/3982
154 rdf:type schema:MonetaryGrant
155 sg:grant.2453232 http://pending.schema.org/fundedItem sg:pub.10.1038/3982
156 rdf:type schema:MonetaryGrant
157 sg:journal.1113716 schema:issn 1078-8956
158 1546-170X
159 schema:name Nature Medicine
160 rdf:type schema:Periodical
161 sg:person.01150335627.93 schema:familyName Buelow
162 schema:givenName R
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150335627.93
164 rdf:type schema:Person
165 sg:person.01315400021.90 schema:familyName Turka
166 schema:givenName L A
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315400021.90
168 rdf:type schema:Person
169 sg:person.014630537777.87 schema:familyName Sayegh
170 schema:givenName M H
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014630537777.87
172 rdf:type schema:Person
173 sg:person.016436741077.30 schema:affiliation https://www.grid.ac/institutes/grid.239395.7
174 schema:familyName Hancock
175 schema:givenName W W
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016436741077.30
177 rdf:type schema:Person
178 sg:pub.10.1038/381434a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027764557
179 https://doi.org/10.1038/381434a0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nm0196-87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001424949
182 https://doi.org/10.1038/nm0196-87
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nm0297-196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034700267
185 https://doi.org/10.1038/nm0297-196
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nm0997-944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049258766
188 https://doi.org/10.1038/nm0997-944
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/(sici)1097-4644(19980101)68:1<121::aid-jcb12>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1010776290
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0167-5699(97)01129-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004631834
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1073/pnas.93.24.13967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040275345
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1083/jcb.134.1.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008630415
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1084/jem.181.5.1869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026977323
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00007890-199309000-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032170234
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00007890-199559040-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018175106
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00007890-199559040-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047216657
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/00007890-199601150-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275595
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/00007890-199707150-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276714
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1097/00007890-199712150-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060277022
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1097/00007890-199805131-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060277317
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1172/jci118483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034508845
215 rdf:type schema:CreativeWork
216 https://www.grid.ac/institutes/grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center
217 schema:name Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. Wayne_Hancock@Leukosite.com
218 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...