A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-10

AUTHORS

Hervé Groux, Anne O'Garra, Mike Bigler, Matthieu Rouleau, Svetlana Antonenko, Jan E. de Vries, Maria Grazia Roncarolo

ABSTRACT

Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to respond in certain circumstances, active suppression mediated by T cells or T-cell factors has been proposed as a mechanism for maintaining peripheral tolerance. However, the inability to isolate and clone regulatory T cells involved in antigen-specific inhibition of immune responses has made it difficult to understand the mechanisms underlying such active suppression. Here we show that chronic activation of both human and murine CD4+ T cells in the presence of interleukin (IL)-10 gives rise to CD4+ T-cell clones with low proliferative capacity, producing high levels of IL-10, low levels of IL-2 and no IL-4. These antigen-specific T-cell clones suppress the proliferation of CD4+ T cells in response to antigen, and prevent colitis induced in SCID mice by pathogenic CD4+CD45RB(high) splenic T cells. Thus IL-10 drives the generation of a CD4+ T-cell subset, designated T regulatory cells 1 (Tr1), which suppresses antigen-specific immune responses and actively downregulates a pathological immune response in vivo. More... »

PAGES

737-742

References to SciGraph publications

  • 1995. Interleukin-10 Deficient Mice in INTERLEUKIN-10
  • Journal

    TITLE

    Nature

    ISSUE

    6652

    VOLUME

    389

    Author Affiliations

    From Grant

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/39614

    DOI

    http://dx.doi.org/10.1038/39614

    DIMENSIONS

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    PUBMED

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