Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-04

AUTHORS

S K Sharan, M Morimatsu, U Albrecht, D S Lim, E Regel, C Dinh, A Sands, G Eichele, P Hasty, A Bradley

ABSTRACT

Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2. More... »

PAGES

804

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    6627

    VOLUME

    386

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/386804a0

    DOI

    http://dx.doi.org/10.1038/386804a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022615608

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9126738


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

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    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/386804a0'


     

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