Activation of prokaryotic transcription through arbitrary protein–protein contacts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

S L Dove, J K Joung, A Hochschild

ABSTRACT

Many transcriptional activators in prokaryotes are known to bind near a promoter and contact RNA polymerase, but it is not clear whether a protein-protein contact between an activator and RNA polymerase is enough to activate gene transcription. Here we show that contact between a DNA-bound protein and a heterologous protein domain fused to RNA polymerase can elicit transcriptional activation; moreover, the strength of this engineered protein-protein interaction determines the amount of gene activation. Our results indicate that an arbitrary interaction between a DNA-bound protein and RNA polymerase can activate transcription. We also find that when the DNA-bound 'activator' makes contact with two different components of the polymerase, the effect of these two interactions on transcription is synergistic. More... »

PAGES

627-630

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/386627a0

DOI

http://dx.doi.org/10.1038/386627a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036416155

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9121589


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