Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-03

AUTHORS

Ed Laufer, Randall Dahn, Olivia E. Orozco, Chang-Yeol Yeo, Jacqueline Pisenti, Domingos Henrique, Ursula K. Abbott, John F. Fallon, Cliff Tabin

ABSTRACT

The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm. More... »

PAGES

366-373

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/386366a0

DOI

http://dx.doi.org/10.1038/386366a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039467436

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9121552


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