pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-02

AUTHORS

Erich Brunner, Oliver Peter, Liang Schweizer, Konrad Basler

ABSTRACT

Members of the Wnt/Wingless (Wg) family of signalling proteins organize many aspects of animal development by regulating the expression of particular target genes in responding cells1–6. Recent biochemical studies7–9 indicate that the vertebrate HMG-domain proteins Lef-1 and XTcf-3 can physically interact with β-catenin, a homologue of Drosophila Armadillo (Arm), the most downstream component known in the Wnt signal transduction pathway10,11. However, these studies do not address whether the endogenous Lef/Tcf family members are required in vivo to transduce Wnt signals. Using genetic methods in Drosophila, we define a new segment polarity gene, pangolin (pan), and show that its product is required in vivo for Wg signal transduction in embryos and in developing adult tissues. In addition, we show that panencodes a Lef/Tcf homologue and provide evidence that its protein product binds to the β-catenin homologue Armadillo in vivo. Finally, we demonstrate that Pan functions downstream of Arm to transduce the Wg signal. Thus, our results indicate that Pan is an essential component of the Wg transduction pathway and suggest that it acts directly to regulate gene transcription in response to Wg signalling. More... »

PAGES

829-833

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/385829a0

DOI

http://dx.doi.org/10.1038/385829a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050861882

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9039917


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