Crystal structure of the Src family tyrosine kinase Hck View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-02

AUTHORS

Frank Sicheri, Ismail Moarefi, John Kuriyan

ABSTRACT

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 Å resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases. More... »

PAGES

602-609

Journal

TITLE

Nature

ISSUE

6617

VOLUME

385

Related Patents

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/385602a0

DOI

http://dx.doi.org/10.1038/385602a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034217411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9024658


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