Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-11

AUTHORS

D N Garboczi, P Ghosh, U Utz, Q R Fan, W E Biddison, D C Wiley

ABSTRACT

Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions. More... »

PAGES

134-141

Journal

TITLE

Nature

ISSUE

6605

VOLUME

384

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/384134a0

    DOI

    http://dx.doi.org/10.1038/384134a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000595640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8906788


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