Gene therapy - promises, problems and prospects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-09-18

AUTHORS

Inder M. Verma, Nikunj Somia

ABSTRACT

The concept behind gene therapy is simple — by delivering corrective genetic material to the cells of a patient the symptoms of disease can be alleviated. But seven years after the first clinical trials on gene therapy began, how far have we come? Gene therapy has not lived up to many of its promises, but the main problem has been in designing efficient delivery vehicles ('vectors'). Nonetheless, the prospects are good — by the year 2010, gene therapy may be as routine a practice as heart transplants are today. More... »

PAGES

239-242

Journal

TITLE

Nature

ISSUE

6648

VOLUME

389

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  • Treatment Of Peripheral Vascular Disease Using Umbilical Cord Tissue-Derived Cells
  • Polyclonal Immunoglobulin For Use In Diagnosis, Prevention And Treatment Of Infection, Cell Proliferative, Blood, Autoimmune And Nervous System Disorders
  • Manf2 For Treatment Of Parkinson's Disease
  • Protein Encoded By The Nucleotide Sequence Represented By Seq Id No: 15; Useful For Diagnosing And Treating Cancer
  • Antihemophilic Factor For Use In The Treatment Of Blood Disorders; Corrects Hemophilia In A Patient Deficient In Factor Viii Or Having Inhibitors To Factor Viii
  • Delivery Of A Neurotrophin To Targeted Defective, Diseased Or Damaged Cholinergic Neurons
  • The Polypeptide Activates One Or More Fgf Receptors, Regulates The Growth And Differentiation Of Cells Within The Liver, Regulates Other Cell Types Following Secretion From The Liver, Plays A Role In Liver Chemotaxis, Has An Oncogenic Activity, Or Serves As An Antigen For Generating Antibodies
  • Pca3 Genes
  • Tumor Suppressor Killin
  • Circuit Arrangement For Injecting Nucleic Acids And Other Biologically Active Molecules Into The Nucleus Of Higher Eucaryotic Cells Using Electrical Current
  • Destruction Of The Epithelium Of An Exocrine Gland In The Prophylactic And Therapeutic Treatment Of Cancer
  • Method Of Controlling L-Dopa Production And Of Treating Dopamine Deficiency
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Growth Hormone Releasing Hormone Expression System And Methods Of Use, Including Use In Animals
  • Methods Of Increasing Lean Tissue Mass Using Ob Protein Compositions
  • Enables The Efficient Integration Of Foreign Dna Into Host Cells; An Integrase Gene, A Segment Of Dna For Controlling The Expression Of The Integrase Gene, And An Integrase Recognition Region When Integrase Catalyzes The Integration Reaction
  • Administering Exogenous Genes
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Medical Equipment Comprising Nucleic Acid Codes For Wild-Type Human Kinase Interacting Stathmin (Hkis) Phosphoproteins, Used For Drug Delivery; Antiproliferative Agents
  • Methods For Producing Micrornas
  • E6 Targeted Protein (E6tp1)
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Compositions And Methods For Angiogenic Therapy Utilizing Genes Encoding Ets-1
  • Have Cationic Charge Densities That Decrease By Removal Of Removable Functional Groups From The Polymers; Non-Immunogenic, Non-Toxic; For Delivery Of A Therapeutic Molecule, A Diagnostic Molecule, A Peptide, Or A Carbohydrate
  • Stress-Responsive Induction Of A Therapeutic Agent And Methods Of Use
  • Dna And Protein For The Diagnosis And Treatment Of Alzheimer's Disease
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Strand Rna Viruses, And Process For The Production Of Such Viruses Encoding Additional Antigenically Active Proteins
  • Vectors Comprising Cell Type-Specific Promoter Elements That Selectively Express Cytotoxic Genes In Tumor Cells
  • Vectorization System Comprising Nanoparticles Of Homogenous Size Of At Least One Polymer And At Least One Positively Charged Polysaccharide And Method For The Preparation Thereof
  • Peptide Inhibitors Of Iaspp
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Anti-P53 Single-Chain Antibody Fragments And Their Uses
  • Methods For Treating Obesity Using Fibroblast Growth Factor-Like Polypeptides
  • Scleroprotein Of An Adeno-Associated Virus With Modified Chromatographic Properties, The Production Thereof And Use Of The Same
  • Cationic Lipopolymer As Biocompatible Gene Delivery Agent
  • Parathyroid Hormone Analogs And Uses Thereof
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Characterization Of Gene Function Using Double Stranded Rna Inhibition
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Non-Ionically Bound Constructs, And Compositions And Kits Comprising Domains
  • Raav Is A Useful Vector For The Stable Expression Of Therapeutic Genes In The Myocardium And Is Used To Deliver Genes For Inducing Angiogenesis, Inhibiting Angiogenesis, Stimulating Cell Proliferation, Inhibiting Cell Proliferation And/Or Treating Or Ameliorating Other Cardiovascular Conditions.
  • Artificial Ubiquitous Chromatin Opening Elements (Ucoe)
  • Methods Of Treating Non-Alcoholic Steatohepatitis Using Fgf21 Mutants
  • Hbv Epitope Reactive Exogenous T Cell Receptor (Tcr) And Uses Thereof
  • Rna Interference Mediating Small Rna Molecules
  • Alternate Site Gene Therapy
  • Chimeric Vectors
  • Comprises Regulatory Polypeptide Which Binds Kinase Interacting Polypeptide For Diagnosis, Prevention And Treatment Of Tumors And Alzheimer's Diseases
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Rna-Guided Gene Editing And Gene Regulation
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Ultra High Affinity Neutralizing Antibodies
  • Regeneration And Repair Of Neural Tissue Using Postpartum-Derived Cells
  • Hutc As Therapy For Alzheimer's Disease
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Compounds And Methods To Enhance Raav Transduction
  • Recombinant P53 Adenovirus Compositions
  • Nucleic Acid Molecules Encoding Fibroblast Growth Factor-Like Polypeptides
  • Ecr673: A 7-Transmembrane G-Protein Coupled Receptor
  • Short Interfering Rnas For Use Treating Viral Diseases, Autoimmune Disease And Tumors; Double Stranded Rna
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
  • Artificial Fusion Protein Has Been Designed Containing An Ldl Receptor Domain Attached To A Localization Domain Which Causes Retention Of The Fusion Protein Inside Of A Cell; Fusion Protein Is Preferably Retained In The Endoplasmic Reticulum Of The Cell, Where The Ldlr Can Degrade Apob
  • Light Emitting Microorganisms And Cells For Diagnosis And Therapy Of Tumors
  • Method Of Controlling L-Dopa Production And Of Treating Dopamine Deficiency
  • Polyclonal Immunoglobulin For Use In Diagnosis, Prevention And Treatment Of Infection, Cell Proliferative, Blood, Autoimmune And Nervous System Disorders
  • Manf2 For Treatment Of Parkinson's Disease
  • Ultrasonic Catheter Power Control
  • Treatment Of Neurological Injury By Administration Of Human Umbilical Cord Tissue-Derived Cells
  • Uses Of Fgf21 Polypeptides Comprising Two Or More Mutations
  • Cancer Treatment With Endothelin Receptor Antagonists
  • Fgf 21 Polypeptides Comprising Two Or More Mutations And Uses Thereof
  • Ultrasound Assembly With Increased Efficacy
  • Plasmid Encoding Feline Bmp-7
  • Transgenic Human Cells Expressing Antiproliferative Agents; Gene Therapy; Anticancer Agents; Tissue Engineering; Generating Immunology Response
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Il-17 Receptor A Antigen Binding Proteins
  • Helper Virus-Free Herpesvirus Vector Packaging System
  • Chimeric Polypeptides And Uses Thereof
  • Antisense Modulation Of Ptp1b Expression
  • Compositions And Methods For The Therapy And Diagnosis Of Lung Cancer
  • Nucleic Acid-Lipopolymer Compositions
  • Correction Of Alpha-1-Antitrypsin Genetic Defects Using Spliceosome Mediated Rna Trans Splicing
  • Tetracycline-Regulated Gene Expression In Hsv-1 Vectors
  • Noncovalent Complex Having Net Positive Charge At Ph 6.0-8.0, The Complex Comprising A Nucleic Acid, At Least One Cationic Lipid, And A Polycation, Where Polycation Is A Cationic Peptide Or A Polypeptide Comprising Polylysine, Polyornithine, Or Polyarginine; Gene Therapy
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
  • Artificial Fusion Protein Has Been Designed Containing An Ldl Receptor Domain Attached To A Localization Domain Which Causes Retention Of The Fusion Protein Inside Of A Cell; Fusion Protein Is Preferably Retained In The Endoplasmic Reticulum Of The Cell, Where The Ldlr Can Degrade Apob
  • Protein; Inducvtion Immunology Response Using Antibodies
  • Exposing Culture Of Cells Which Transiently Expresses Receptor Potential Protein To Compounds, Determining If Exposure Affects Gene Expression Of That Protein
  • Nucleic Acid Molecules Encoding Fibroblast Growth Factor-Like Polypeptides
  • Method Of Delivery Of Nucleic Acids To A Developing Embryo
  • Compositions And Methods For Polynucleotide Delivery
  • Recombinant P53 Adenovirus Compositions
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Mammalian Cell Lines Expressing Bovine Adenovirus Functions
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Rna-Guided Gene Editing And Gene Regulation
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Rna Interference Mediating Small Rna Molecules
  • Alternate Site Gene Therapy
  • Ultra High Affinity Neutralizing Antibodies
  • Characterization Of Gene Function Using Double Stranded Rna Inhibition
  • Parathyroid Hormone Analogs And Uses Thereof
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Expression Or Activation Of An Er Resident Chaperone Protein
  • Herpes Simplex Virus Vaccines
  • Ecr673: A 7-Transmembrane G-Protein Coupled Receptor
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Compounds And Methods To Enhance Raav Transduction
  • Short Interfering Rnas For Use Treating Viral Diseases, Autoimmune Disease And Tumors; Double Stranded Rna
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Prepared From Autologous Lymphoma Cells Transfected With Emm55; For Canines; The Modified Cancer Cells Are Highly Immunogenic To The Host, Yet Show No Toxic Side Effects
  • Duplexed Parvovirus Vectors
  • Modified Polynucleotides Encoding Cited4
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Targeted Chromosomal Genomic Alterations With Modified Single Stranded Oligonucleotides
  • Wnt-3 Polynucleotides
  • Modified Polynucleotides For Treating Protein Deficiency
  • Targeting Slow-Growing, Relatively Mutationally Spared Cancer Stem Line; Early Cancer Treatment And Reduce The Likelihood Of Clinical Relapse
  • Isolating And Expressing These Nucleic Acids And Proteins, Which Have Application To The Control Of Cell Proliferation And Aging, Including The Control Of Age-Related Diseases, Such As Cancer
  • Containing An Immunogenic Amount Of A C. Psittaci Major Outer Membrane Protein (Momp) Polypeptide Lacking Regions Vd1 And Vd2; Nucleic Acid Vectors For The Expression Of Momp Polypeptides And Momp Polypeptide Fusion Proteins; Immunization
  • Materials And Methods For Prevention And Treatment Of Rna Viral Diseases
  • Method Of Treating Bone Disorders Using Tsg-6
  • Virology And Gene Therapy; Modified Fiber Knob Retains Its Ability To Trimerize And Retains Its Native Biosynthesis Profile
  • Human Antigen Binding Proteins That Bind Β-Klotho, Fgf Receptors And Complexes Thereof
  • Binding Proteins That Bind To Human Fgfr1c, Human Β-Klotho And Both Human Fgfr1c And Human Β-Klotho
  • Administering Polypeptide; Prostate Gland Disease
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Compositions And Methods For Treating Pancreatic Cancer
  • Universal Gm-Csf Expressing Bystander Human K562 Cell Line
  • Method Of Inhibiting Cell Proliferation Using An Anti-Oncogene Protein
  • Disintegrin And Metalloproteinase Containing Thrombospondin 1-Like Domains (Adamts); Adamts13 Protease And To Nucleic Acids Encoding Adamts13 Proteases; Von Willebrand Bactor Cleaving Protease Activity; Treating Acquired Thrombotic Thrombocytopenic Purpura; Anticoagulant Drug Development
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Method For Introducing A Molecule Into The Cytosol Of A Cell In Which The Cell Is Contacted With A Photosensitising Agent, The Cell Is Irradiated With Light Of A Wavelength Effective To Activate The Photosensitising Agent And, Substantially At The
  • Retrovirus Packaging Cell
  • Detecting Modulator Of Enzyme Activity; Obtain Enzymatic Sample, Incubate With Modulator, Monitor Enzymatic Activity
  • Delivery Of A Neurotrophin To Targeted Defective, Diseased Or Damaged Cholinergic Neurons
  • Antihemophilic Factor For Use In The Treatment Of Blood Disorders; Corrects Hemophilia In A Patient Deficient In Factor Viii Or Having Inhibitors To Factor Viii
  • Adeno-Associated Virus Materials And Methods
  • Methods For Enhanced Virus-Mediated Dna Transfer Using Molecules With Virus- And Cell-Binding Domains
  • Forming Densified Nucleic Acid Gene Material Without Biolistic Core Carrier For Transdermal Delivery Needleless Injection
  • Tetracycline Repressor Regulated Oncolytic Viruses
  • Modified Factor Viii
  • Regulatory Sequences Capable Of Conferring Expression Of A Heterologous Dna Sequence In Endothelial Cells In Vivo And Uses Thereof
  • Means And Methods For The Specific Modulation Of Target Genes In The Cns And The Eye And Methods For Their Identification
  • Hutc As Therapy For Alzheimer's Disease
  • Cr-2 Binding Peptide P28 As Molecular Adjuvant For Dna Vaccines
  • Identifying Modulators Of Fibroblast Growth Factor-Like Polypeptides
  • Transforming Embryos Or Cells Associated With Egg Production; Insert Vector Into Aggregations, Insert Genetically Engineered Virus Into Aggregations, Detect Egg Laying Animals Expressing Preferential Sequences
  • Il-17 Receptor Antibody Formulation
  • Using Serine Recombinase As Nucleotide Sequence Insertional Tool For Generating Transgenic Cells, Tissues Or Plants; Site Specific Recombination And Gene Therapy
  • Treatment Of Amyloidogenic Diseases
  • Fk506-Based Regulation Of Biological Events
  • Fgf21 Mutants Multimers And Uses Thereof
  • Polynucleotides For Reducing Respiratory Syncytial Virus Gene Expression
  • Her2 Dna Vaccine As Adjunct Treatment For Cancers In Companion Animals
  • Methods Of Treating Parkinson's Disease Using Viral Vectors
  • Use Of Such Proteins In Isolating Various Types Of Attenuated Viruses For The Development Of Vaccine And Pharmaceutical Formulations; Protocols Utilizing Interferon Antagonists, E.G., Ns1, To Enhance Gene Therapy Or Dna Vaccination Based On Their Ability To Increase Gene Expression
  • Using Prostate Cancer Antigen (Pca) Expression As Evaluative Tool In Diagnosis/Prognosis Of Cancer
  • Mutations That Confer Genetic Stability To Additional Genes In Influenza Viruses
  • Treatment Of Peripheral Vascular Disease Using Umbilical Cord Tissue-Derived Cells
  • E.G. (6,7-(Dimethoxyquinazolin-4-Yl)-(3-Ethynylphenyl)-Amine; Epidermal Growth Factor Receptor (Egf-R) Antagonist, Tyrosine Kinase Inhibitor; Hypersecretion Of Mucus In Lungs: Chronic Bronchitis, Acute Asthma, Cystic Fibrosis, Bronchiectasis, Chronic Obstructive Lung Disease
  • Chimeric Viruses Presenting Non-Native Surface Proteins And Uses Thereof
  • Dna Molecules Encoding Single Strand Gap Response Proteins Involved In Activation Of A Dna Repair/Cell Cycle Checkpoint Pathway
  • A Vector Comprising A Nucleotide Sequence Of Interest ("Noi") Encoding A Product Of Interest ("Poi") Is Described. The Noi And/Or The Poi Is Capable Of Recognizing A Tumor, Such That In Use The Vector Is Capable Of Delivering The Noi And/Or The Poi
  • Cr-2 Binding Peptide P28 As Molecular Adjuvant For Dna Vaccines
  • Methods Of Activating Ret Receptor Tyrosine Kinase Using Neurotrophic Factors
  • The Polypeptide Activates One Or More Fgf Receptors, Regulates The Growth And Differentiation Of Cells Within The Liver, Regulates Other Cell Types Following Secretion From The Liver, Plays A Role In Liver Chemotaxis, Has An Oncogenic Activity, Or Serves As An Antigen For Generating Antibodies
  • Pca3 Genes
  • Methods And Means For Targeted Gene Delivery
  • Polymer-Conjugated Glycosylated Neublastin
  • Lead Electrode Incorporating Extracellular Matrix
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Anti-Nucleolin Agent-Conjugated Nanoparticles As Radio-Sensitizers And Mri And/Or X-Ray Contrast Agents
  • Neurotrophic Factors
  • For Stimulation Of Production Of Growth Hormone In An Animal; Gene Therapy
  • Recombinant Protein Bodies As Immunogen-Specific Adjuvants
  • Vascular Endothelial Growth Factor; Hypoxia Responsive Element; Amyotrophic Lateral Sclerosis
  • Targeting Molecule Linked To An Imaging Agent
  • Coding For Apoptosis Inhibitor Proteins
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Covalent Coupled Of Nucleic Acids, Peptides Or Proteins To Active Material For Enhancing Transfection Efficiency; Potentiation
  • Febp1 Protein: Vector, Host Cells And Method For Making Febp1 Protein
  • By Detecting Alteration Of Effector Genes Such As Chloramphenicol Acetyltransferase; Used For Anticarcinogenic Agents
  • Nucleotide Sequences Coding Preferential Polypeptide For Use In Treatment Of Sleep Disorder
  • Controlling Gene Expression Inhibition In Cells; Obtain Cells, Transform With Preferential Nucleotide Sequences, Recover Transform Cells, Monitor Gene Expression, Adjustment In Gene Expression, Indicate Gene Expression Inhibitor
  • Nonsystemically Administering An Exogenous Nucleic Acid Linked To A Promoter And Flanked By Native Parvoviral Inverted Terminal Repeats To Non-Neuronal Tissue Of Mammal; Gene Expression Continues Past 28 Days
  • Human Abc1 Promoter And Assays Based Thereon
  • For Transferring Dna And/Or Rna, Such As Genes, To Cells By Photochemically Inducing The Disruption Of Endosomes And Lysosomes
  • Administering Nucleic Acid Molecule Encoding Retinoblastoma Protein-Interacting Zinc Finger Protein At Or Adjacent To Site Of Tumor, Wherein Protein Comprises Specified Amino Acid Sequence And Is Expressed In Tumor Cell And Reduces Its Growth
  • Cell Lines
  • Enhancing Conversion Of Single Stranded Adeno-Associated Virus To Double Stranded; Infecting Target Cells With The Recombinant Virus And Exposing The Infected Cells To An Agent; Gene Therapy Cancer And Cystic Fibrosis
  • Use Of Marrow-Derived Glial Progenitor Cells As Gene Delivery Vehicles Into The Central Nervous System
  • Lipid Complexes For Transferring At Least A Therapeutically Active Substance, In Particular A Polynucleotide Into A Target Cell And Use In Gene Therapy
  • Artificial Chromosomes, Uses Thereof And Methods For Preparing Artificial Chromosomes
  • Modified Factor Viii
  • Infection And Treatment Of Neoplasms With Vesicular Stomatitis Virus
  • Nucleolin Antibodies
  • Methods And Compositions For The Inhibition Of Trpv4
  • Using Denaturation And Renaturation Ratios To Determine Evolutionary Relationships Between Viral Species
  • Ob Fusion Protein Compositions And Methods
  • Microorganisms For Therapy
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Compositions And Methods For The Therapy And Diagnosis Of Colon Cancer
  • Repair And Regeneration Of Ocular Tissue Using Postpartum-Derived Cells
  • Methods And Compositions For Promoting Survival And Proliferation Of Endothelial Cells And Stimulating Angiogenesis
  • Dextrin Polymers In Combination With Sugars Provide Enhanced Delivery Of Nucleic Acids, Particularly Eucaryotic Expression Vectors, Demonstrate Enhanced Delivery Of Nucleic Acids To Cells In Vivo
  • Humanized Aβ Antibodies For Use In Improving Cognition
  • Hepatitis Therapeutics
  • Double-Stranded Oligonucleotides
  • Suppression Of Rejection Of Grafted Synthetic Or Allogenic Organ Or Grafted Tissue To Be Transplanted With Dna Encoding
  • Preventing Airway Mucus Production By Administration Of Egf-R Antagonists
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Methods For Encapsulating Nucleic Acids In Lipid Bilayers
  • Thrombopoietic Compounds
  • Methods Of Treating Various Cancers Using Melanoma Differentiation Associated Protein-7
  • Defective Recombinant Adenovirus Comprising A Nucleic Acid Sequence Coding For A Biologically Active Human Lipoprotein Lipase
  • Anti-Il-17 Receptor A Neutralizing Antibodies
  • Contacting A Cell Expressing A Human Sodium Phosphate Co-Transporter Npt2b Polypeptide Having A Specific Amino Acid Sequence On Its Surface With A Candidate Agent In The Presence Of Phosphorus Anion; An Altered Uptake In The Amount Of Phosphorous Agent Identifies An Npt2b Modulatory Agent
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • High Potency Recombinant Antibodies And Method For Producing Them
  • Vascular Endothelial Growth Factor 2
  • The Enzyme Maintains Methionine Synthase In Its Reduced, Activated State, And Hence Is An Essential Component Of The Methionine Synthetic Pathway.
  • Delivery Of Therapeutic Gene Products By Intestinal Cell Expression
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Epicardial Patch Including Isolated Extracellular Matrix With Pacing Electrodes
  • Implantable Drug Delivery Device And Use Thereof
  • Materials And Methods For Delivery And Expression Of Heterologous Dna In Vertebrate Cells
  • Interleukin-4 (Il-4) Mutein Receptor Antagonist Operatively Linked To An Interleukin-9 (Il-9) Mutein Receptor Antagonist; Can Specifically Disrupt The Formation Of An Il-4 Receptor, An Il-9 Receptor, An Interleukin-13 (Il-13) Receptor; Useful In Treatment Of Asthma And Other Pulmonary Disorders
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Refolding Transforming Growth Factor Beta Family Proteins
  • Oxygen Sensing And Hypoxic Selection For Tumors
  • Modified Polynucleotides Encoding Septin-4
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Recombinant Adeno-Associated Virus (Raav) Vector Comprising A Heterologous Sequence And Heparin; For Gene Therapy
  • Transducing Neuron With Gene; Muscular Disorders
  • Replication-Competent Anti-Cancer Vectors
  • Light Emitting Microorganisms And Cells For Diagnosis And Therapy Of Diseases Associated With Wounded Or Inflamed Tissue
  • Methods Of Treating Metabolic Disease
  • Human Antigen Binding Proteins That Bind Β-Klotho, Fgf Receptors And Complexes Thereof
  • Replication-Defective Recombinant Virus Includes Promoter From Human Major Intrinsic Protein Or Human Crystallin And An Open Reading Frame Of Human Ras, Herpes Simplex Type I Thymidine Kinase, Or Non-Phosphorylatable Retinoblastoma
  • Genomes, Gag, Pol And Envelope Proteins
  • Osteoblast-Specific Transcription Factor (Osf2/Cbfa1); Polypeptides/Polynucleotides That Regulate Osteoblast Differentiation And Stimulate Bone Growth; Immunoassays; Detection Kits; Drug Screening
  • Use Of Scatter Factor To Enhance Angiogenesis
  • Histone Acetylase Inhibitor
  • Cloning Of Reporter Genes And Cdna Encoding For Therapeutic Proteins For The Treatment Of Hepatic, Pulmonary, Renal, Heart, Pancreas Fibrosis, Keloids And Hypertrophic Scars, In Mammals, Including Human Beings
  • Therapeutic Dna Vaccination
  • Il-17 Receptor A Antigen Binding Proteins
  • Fgf21 Mutants And Uses Thereof
  • System For Optical Stimulation Of Target Cells
  • Materials And Methods For Reducing Inflammation By Inhibition Of The Atrial Natriuretic Peptide Receptor
  • Methods And Compositions For Detection Of Microorganisms And Cells And Treatment Of Diseases And Disorders
  • Calpain Inhibitors And Their Applications
  • Methods And Compositions For Treating Metastatic Cancer
  • Replication-Competent Anti-Cancer Vectors
  • Newcastle Disease Viruses And Uses Thereof
  • Composition And Method For Inhibiting Tumor Cell Growth
  • Compounds And Methods For Therapy And Diagnosis Of Lung Cancer
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Nucleic Acids Encoding Fluorescent Proteins And Methods Of Using The Same
  • For Extending Clinical Utility Of Interferon (Ifn) Alpha In Treatment Of A Variety Of Viral And Proliferative Disorders; Increase Efficacy Of Ifn- Alpha And Reduce Ifn- Alpha Treatment-Related Side Effects
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Ob Fusion Protein Compositions And Methods
  • Gene Delivery Vehicle Expressing The Aptosis-Inducing Proteins Vp2 And/Or Apoptin
  • Adeno-Associated Virus Materials And Methods
  • Vectors And Methods For Immunization Or Therapeutic Protocols
  • Expression Vector Comprising Nucleotide Sequences Coding Calcium Channel Pump (Calbindin) For Use In Identifying Modulators For Diagnosis, Prevention And Treatment Of Glucocorticoid Induced Osteoporosis
  • Delivery Of Physiological Agents With In-Situ Gels Comprising Anionic Polysaccharides
  • Targetting Slow-Growing, Relatively Mutationally-Spared Cancer; One-Step Genetic Switches; Antiproliferative Agents; Magnetic Resonance Imaging
  • Remedies For Hepatitis
  • Biodegradable Immunomodulatory Formulations And Methods For Use Thereof
  • Medicament Comprising Hgf Gene
  • Compositions And Methods For Treating Intracellular Diseases
  • Herpes Simplex Virus Amplicon Vector Targeting System And Method Of Using Same
  • Attenuated Viruses Comprising Modified Ns1 Genes, Having An Impaired Ability To Antagonize The Cellular Interferon Response; Decreased In Vivo Replication, Virulence And Increased Attenuation; Live Cancer Vaccines
  • Introducing Nucleic Acid Molecule Encoding Protein Selected From Neuronal Apoptosis Inhibitory Protein And Inhibitor Of Apoptosis Protein Sufficient To Produce Increase In Likelihood Of Neuron Surviving In Vitro Relative To Untreated Control
  • Antitumor Agents; Gene Therapy
  • Microorganisms For Therapy
  • G-Protein Coupled Receptors
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Serotype Of Adenovirus And Uses Thereof
  • Antitumoral Composition Based On Immunogenic Polypeptide With Modified Cell Location
  • P53 Vaccines For The Treatment Of Cancers
  • Liver Regeneration Using Pancreas Cells
  • Treatment Of Stroke And Other Acute Neuraldegenerative Disorders Using Postpartum Derived Cells
  • Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter
  • Structural Protein Of Adeno-Associated Virus With Modified Antigenicity, Its Production And Its Use
  • Polymer Conjugated Glycosylated Neublastin
  • Inhibition Of Pex In The Treatment Of Metabolic Bone Diseases
  • Ex Vivo Gene Therapy For Hiv; Formulation Of Cd34+ Hematopoietic Cells Transduced With A Viral Construct Which Expresses An Anti-Hiv Agent Such As A Ribozyme
  • Cross-Species-Specific Psmaxcd3 Bispecific Single Chain Antibody
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Methods For Preventing Formation Of Inhibitory Antibodies In The Setting Of Gene Therapy
  • Branched Dendrimeric Structures
  • Antisense Modulation Of Ptp1b Expression
  • Human Antigen Binding Proteins That Bind Β-Klotho, Fgf Receptors And Complexes Thereof
  • Dopaminergic Neurons Differentiated From Embryonic Cells For Treating Neurodegenerative Diseases
  • Antisense Modulation Of Ptp1b Expression
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Genetic Suppression And Replacement
  • Rna Interference Mediating Small Rna Molecules
  • Compositions And Methods For Regulating Angiogenesis
  • Nucleotide Sequences, Proteins, Drugs And Diagnostic Agents Of Use In Treating Cancer
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Alphavirus Replicon Vector Systems
  • Vector
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Recombinant Animal Viral Nucleic Acids
  • Treatment Of Melanoma Using Hsv Mutant
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Use Of Vegf And Homologues To Treat Neuron Disorders
  • Given Nucleotide Sequence; Use In Diagnosis And Treatment Of Rheumatoid And Osteo-Arthritis
  • Introducing Foreign Dna Into Cell; Contacting Before, During, Or After With Biocompatible Expression Enhancing Agent Which Is Not Butyrate Or Butyric Acid; Maintaining In Non-Selective Medium; After 5 Days, Detecting Foreign Protein
  • High Titer Recombinant Influenza Viruses For Vaccines
  • Methods And Compositions For Enhancing Intranasal Delivery Of Therapeutic Agents
  • Pharmaceutical Compositions With Resistance To Soluble Cea
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Transfection Efficiency
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Expression Of Hiv Polypeptides And Production Of Virus-Like Particles
  • Genetic Vaccines Comprising A Recombination Activating Gene (Rag) Nucleotide Sequence, Used To Code Polypeptides, For The Prevention And/Or Treatment Of Periodontal Diseases, Caused By Infection By Porphyromonas Gingivalis
  • Methods Of Cancer Diagnosis And Therapy Targeted Against A Cancer Stem Line
  • P53 As A Regulator Of Cell Differentiation
  • Hcv Variants
  • Cell-Mediated Targeting Of Toxins To Pathogenic Cells
  • Gene Transfer Into Airway Epithelial Stem Cell By Using Lentiviral Vector Pseudotyped With Rna Virus Or Dna Virus Spike Protein
  • Influenza Virus Replication For Vaccine Development
  • Variants Of Pigment Epithelium Derived Factor And Uses Thereof
  • Immunostimulatory Polynucleotide/Immunomodulatory Molecule Conjugates
  • Anti-Nucleolin Agent-Conjugated Nanoparticles
  • Intravascular Delivery Of Nucleic Acid
  • Ehrlichia Canis Genes And Vaccines
  • For Gene Therapy; Improved Retrovirus Vector Packaging
  • Specific Inhibition Of Expression Of Target Gene In Mammals Using Short Double Stranded Rna; Dsrna Less Than 49 Nucleotides In Length, Has Nucleotide Sequence Complementary To Part Of Target Gene; Treating Cancer, Alzheimer's Disease
  • Gene Delivery Vectors Provided With A Tissue Tropism For Smooth Muscle Cells, And/Or Endothelial Cells
  • Methods For Modulating Skeletal Remodeling And Patterning By Modulating Shn2 Activity, Shn3 Activity, Or Shn2 And Shn3 Activity In Combination
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Expression Cassette Generated From These Sequences; Generating An Immune Response In A Subject
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Use Of Adenoviral E4 Reading Frames To Improve Expression Of A Gene Of Interest
  • Nucleic Acids Encoding Sb10 Variants
  • Methods Of Ameliorating Symptoms Of Herpes Infection Using Immunomodulatory Polynucleotide Sequences
  • Kiaa0175 Inhibitor Is Selected From The Group Consisting Of An Anti-Sense Molecule, A Ribozyme, An Antibody, An Antibody Fragment, A Protein, A Polypeptide And A Small Molecule.
  • Postpartum Cells Derived From Umbilical Cord Tissue, And Methods Of Making And Using The Same
  • Compositions And Methods Of Altering Cholesterol Levels
  • Treatment Of Neoplasms With Rna Viruses
  • Infant Gene Therapy
  • Rna Interference Mediating Small Rna Molecules
  • Complementing Cell Lines
  • Induction Of A Protective Immune Response Through Microprojectiles Coated With A Dna Sequence Encoding An Immunogenic Protein
  • Polynucleotides Encoding Antigenic Hiv Type C Polypeptides, Polypeptides And Uses Thereof
  • Cell Populations, Methods Of Transdifferentiation And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Proteins
  • Oligonucleotide-Directed Repair Or Alteration Of Genetic Information
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Circovirus Sequences Associated With Piglet Weight Loss Disease (Pwd)
  • Adenovirus Vectors Containing Cell Status-Specific Response Elements And Methods Of Use Thereof
  • Inositol 1,4,5-Triphosphate (Ip3); Use In Gene Therapy Of Diseases Associated With Calcium Production In The Nervous System, Blood Vascular System, Respiratory System, Digestive System, Lymphatic System, Urogenital System
  • Biomarkers And Combination Therapies Using Oncolytic Virus And Immunomodulation
  • Antisense Modulation Of Ptp1b Expression
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Methods And Compositions For Treating Metastatic Cancer
  • Microorganisms For Therapy
  • Introducing Nucleic Acid Molecule Encoding Protein Selected From Neuronal Apoptosis Inhibitory Protein And Inhibitor Of Apoptosis Protein Sufficient To Produce Increase In Likelihood Of Neuron Surviving In Vitro Relative To Untreated Control
  • Antitumoral Composition Based On Immunogenic Polypeptide With Modified Cell Location
  • Ob Fusion Protein Compositions And Methods
  • Gene Delivery Vehicle Expressing The Aptosis-Inducing Proteins Vp2 And/Or Apoptin
  • Adeno-Associated Virus Materials And Methods
  • Compositions And Methods For Treating Intracellular Diseases
  • Herpes Simplex Virus Amplicon Vector Targeting System And Method Of Using Same
  • Attenuated Viruses Comprising Modified Ns1 Genes, Having An Impaired Ability To Antagonize The Cellular Interferon Response; Decreased In Vivo Replication, Virulence And Increased Attenuation; Live Cancer Vaccines
  • Biodegradable Immunomodulatory Formulations And Methods For Use Thereof
  • Medicament Comprising Hgf Gene
  • Delivery Of Physiological Agents With In-Situ Gels Comprising Anionic Polysaccharides
  • Targetting Slow-Growing, Relatively Mutationally-Spared Cancer; One-Step Genetic Switches; Antiproliferative Agents; Magnetic Resonance Imaging
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Nucleic Acids Encoding Fluorescent Proteins And Methods Of Using The Same
  • Vectors And Methods For Immunization Or Therapeutic Protocols
  • Newcastle Disease Viruses And Uses Thereof
  • Composition And Method For Inhibiting Tumor Cell Growth
  • Compositions And Methods For Regulating Angiogenesis
  • Compounds And Methods For Therapy And Diagnosis Of Lung Cancer
  • For Extending Clinical Utility Of Interferon (Ifn) Alpha In Treatment Of A Variety Of Viral And Proliferative Disorders; Increase Efficacy Of Ifn- Alpha And Reduce Ifn- Alpha Treatment-Related Side Effects
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Antitumor Agents; Gene Therapy
  • Expression Vector Comprising Nucleotide Sequences Coding Calcium Channel Pump (Calbindin) For Use In Identifying Modulators For Diagnosis, Prevention And Treatment Of Glucocorticoid Induced Osteoporosis
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Cloning Of Reporter Genes And Cdna Encoding For Therapeutic Proteins For The Treatment Of Hepatic, Pulmonary, Renal, Heart, Pancreas Fibrosis, Keloids And Hypertrophic Scars, In Mammals, Including Human Beings
  • Introducing Foreign Dna Into Cell; Contacting Before, During, Or After With Biocompatible Expression Enhancing Agent Which Is Not Butyrate Or Butyric Acid; Maintaining In Non-Selective Medium; After 5 Days, Detecting Foreign Protein
  • High Titer Recombinant Influenza Viruses For Vaccines
  • Methods And Compositions For Enhancing Intranasal Delivery Of Therapeutic Agents
  • Methods And Compositions For The Inhibition Of Trpv4
  • Multimeric Forms Of Members Of The Steroid/Thyroid Superfamily Of Receptors With The Ultraspiracle Receptor
  • Epidermal Growth Factor
  • Cell Permeable Peptides For Inhibition Of Inflammatory Reactions And Methods Of Use
  • Delivering Viral Vectors To The Cns Are Provided.
  • Targeted Integration And Expression Of Exogenous Nucleic Acid Sequences
  • Lipoxygenase Proteins And Polynucleotides Encoding The Same
  • Treating Diabetes Or Obesity Using Isolated Polypeptide Is Covalently Modified With A Water-Soluble Polymer
  • Altering Human Immune Response To Adenoviral Vector Via Modification Of Capsid Proteins; Improved Exogenous Gene Expression
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Imaging, Diagnosis And Treatment Of Disease
  • Functional Dna Clone For Hepatitis C Virus (Hcv) And Uses Thereof
  • Conformationally Constrained Parathyroid Hormone (Pth) Analogs
  • Vectors Comprising Cpg Islands Without Position Effect Varigation And Having Increased Expression
  • Polypeptide Variants Of Sleeping Beauty Transposase
  • Polypeptide Derivatives Of Parathyroid Hormone (Pth)
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Chimeric Adenoviruses
  • Polymer Conjugated Glycosylated Neublastin
  • Inhibition Of Pex In The Treatment Of Metabolic Bone Diseases
  • Replication-Competent Anti-Cancer Vectors
  • Ex Vivo Gene Therapy For Hiv; Formulation Of Cd34+ Hematopoietic Cells Transduced With A Viral Construct Which Expresses An Anti-Hiv Agent Such As A Ribozyme
  • Cross-Species-Specific Psmaxcd3 Bispecific Single Chain Antibody
  • Therapeutic Dna Vaccination
  • Il-17 Receptor A Antigen Binding Proteins
  • Calpain Inhibitors And Their Applications
  • P53 Vaccines For The Treatment Of Cancers
  • Remedies For Hepatitis
  • Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter
  • Structural Protein Of Adeno-Associated Virus With Modified Antigenicity, Its Production And Its Use
  • Treatment Of Stroke And Other Acute Neuraldegenerative Disorders Using Postpartum Derived Cells
  • Hybrid Amyloid-Beta Antibodies
  • Influenza Virus Replication By Inhibiting Microrna Lec7c Binding To Influenza Viral Crna And Mrna
  • Retroviral Vector For The Transfer And Expression Of Genes For Therapeutic Purposes In Eukaryotic Cells
  • Mmsc2—An Mmac1 Interacting Protein
  • Lipid And Fusogenic Peptide Complex For Delivery Into Cell Nucleus
  • Antibodies Against The Rgm A Protein And Uses Thereof
  • Methods For Regulating The Specific Lineages Of Cells Produced In A Human Hematopoietic Cell Culture, Methods For Assaying The Effect Of Substances On Lineage-Specific Cell Production, And Cell Compositions Produced By These Cultures
  • Dna Viral Vector Comprising Nucleotide Seuences Coding Modified Capsid Protein For Use In Enhancement Of Heterologous Gene Transfer; Improved Exogenous Gene Expression
  • Administering Nucleic Acid Molecule Encoding Hepatocyte Growth Factor Directly To Affected Abdominal Lateral Cardiac Muscle Of Mammal Using Echocardiographic Guidance Without Thoracotomy, Where Nucleic Acid Molecule Is Encapsulated In Sendai Virus
  • Sphingolipid-Containing Cationic Liposomes For Topical Delivery Of Bioactive Material
  • Modified Rna With Decreased Immunostimulatory Properties
  • Human Umbilical Cord Tissue Cells For Inhibiting Adverse Immune Response In Histocompatibility-Mismatched Transplantation
  • Fgf-21 Mutants Comprising Polyethylene Glycol And Uses Thereof
  • A Transgenic Mouse; The Enzyme For Treating Inflammation, Smooth Muscle Contraction; Animal Models
  • Porcine Adenovirus Type 3 Genome
  • Variants Of Pigment Epithelium Derived Factor And Uses Thereof
  • Composition And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis And Abnormal Cell Proliferation
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Compositions For Targeted Gene Delivery
  • Methods For The Treatment Of Inflammatory Joint Disease
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • High Bone Mass Gene Of 11q13.3
  • Expression Of Hiv Polypeptides And Production Of Virus-Like Particles
  • Genetic Vaccines Comprising A Recombination Activating Gene (Rag) Nucleotide Sequence, Used To Code Polypeptides, For The Prevention And/Or Treatment Of Periodontal Diseases, Caused By Infection By Porphyromonas Gingivalis
  • Formulation And Delivery Of Plga Microspheres
  • Delivery Of Polynucleotides By Secretory Gland Expression
  • Administering An Adenovirus Expression Vector, Expressing A Protein On Cancer Cells For Treating Ovarian Cancer, Cervical Cancer, Stomach Cancer And Lung Cancer
  • Feline Granulocyte Macrophage Colony Stimulating Factor Proteins
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulation Of Angiogenesis And Anticancer Therapy
  • Cancer Treatment With Endothelin Receptor Antagonists
  • Anti-Cd98 Antibody Processes
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • For Diagnosing Degenerative Disorders Characterized In Inappropriate Cell Proliferation Or Inappropriate Cell Death; Formonitoring The Progress Of Such Degenerative Disorders
  • High Efficiency Delivery Of Nucleic Acid Molecules Into Cells; Permeabilizing Target Cells To Facilitate Nucleic Acid Uptake; Use In Gene Transfer, Gene Therapy, Disease Treatment
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Prostate-Specific Antigen
  • Double-Stranded Oligonucleotides
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulation Of Angiogenesis And Anticancer Therapy
  • Formulation And Delivery Of Plga Microspheres
  • Delivery Of Polynucleotides By Secretory Gland Expression
  • Polynucleotides Encoding Il-17 Receptor A Antigen Binding Proteins
  • Adenovirus E4 Proteins For Inducing Cell Death
  • Adenoviral Vector Encoding Human Atonal Homolog-1 (Hath1)
  • High Molecular Weight, Low Methoxyl Pectins, And Their Production And Uses
  • Cell Culture Methods For Producing Recombinant Proteins In The Presence Of Reduced Levels Of One Or More Contaminants
  • Immunizing Fish Against Bacterial And Viral Infection By Immersing The Fish In A Solution Comprised Of An Effective Amount Of Dead Or Attenuated, Whole-Celled Recombinant Bacteria, The Recombinant Bacteria Having A Eukaryotic Expression Vector (Plasmid) Incorporated Therein Having Dna Of Interest
  • Artificial Chromosomes, Uses Thereof And Methods For Preparing Artificial Chromosomes
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Using Dispersed Regulatory Nucleotide Sequences To Regulate Transcription In Animal Cells, Tissues And/Or Organs; Gene Expression Inhibition
  • Herpes Simplex Virus; Genetic Engineering
  • Transducing Neuron With Gene; Alzheimer's Disease, Parkinson's Disease, Amyotropic Lateral Sclerosis
  • Compositions And Methods For Treating Diseases
  • Treating A Vascular Disease, Administering A Double Stranded Nucleic Acid Specific Binding To A Transcription Factor; Antiproliferative Agents
  • Use Of The P-Ten Suppressor Gene In Diagnosis And Treatment Of Cancer
  • Method Of Intracellular Binding Of Target Molecules
  • Administering To Respiratory Tract; Phase Inversion Microencapsulation; Noninvasive
  • Nucleotide Sequences Which Code A Membrane Protein For Use In Flavor Intensification Of In Food, Beverages Or Pharmaceuticals
  • Methods And Means For Obtaining Modified Phenotypes
  • Humanized Fcγr Mice
  • A Transgenic Mouse; The Enzyme For Treating Inflammation, Smooth Muscle Contraction; Animal Models
  • Porcine Adenovirus Type 3 Genome
  • Methods And Compositions For Using Sax2
  • Metabolically Activated Recombinant Viral Vectors And Methods For Their Preparation And Use
  • Antisense Modulation Of Ptp1b Expression
  • Methods Of Suppressing Hepatitis Virus Infection Using Immunomodulatory Polynucleotide Sequences
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Comprising A Transcription Cassette Containing A Sequence Coding For A Recombinase, A Minimal Promoter, And A Transcription Binding Site; Gene Therapy For Cancer
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Genetic Demonstration Of Requirement For Nkx6.1, Nkx2.2 And Nkx6.2 In Ventral Neuron Generation
  • Altering Human Immune Response To Adenoviral Vector Via Modification Of Capsid Proteins; Improved Exogenous Gene Expression
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Treating Diabetes Or Obesity Using Isolated Polypeptide Is Covalently Modified With A Water-Soluble Polymer
  • High Efficiency Delivery Of Nucleic Acid Molecules Into Cells; Permeabilizing Target Cells To Facilitate Nucleic Acid Uptake; Use In Gene Transfer, Gene Therapy, Disease Treatment
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Expression Vectors Having A Reduced Content Of Viral Genes, Are Safer Because Of Expressing More Nonviral Nucleotide And Much Less Immunogenic Or Toxic Proteins; Contain Less Than 400 Bp Of The Nucleotide Sequwence Which Codes For Gag
  • Obtaining Long Lasting Immunity Via Delivery To Antigen Presenting Cell A Complex Comprising Nucleic Acid Encoding First Epitope And Peptide Containing Second Epitope
  • Ultrasonic Catheter Power Control
  • Identifying Viricidal Agents Which Prevent Cytomegalo Viral Infection And Distribution; Gene Expression Inhibition
  • Introducing At Least One Modification Into A Structural Protein Of Adeno-Associated Virus (Aav) The Structural Protein Being Selected From The Group Consisting Of Aav Vp1, Vp2, And Vp3, Wherein The Modification Brings About A Reduction In The Antigenicity Of The Virus Relative To Wild-Type Aav
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Biodegradable Immunomodulatory Formulations And Methods For Use Thereof
  • Gene Overexpressed In Cancer
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Post-Transcriptional Gene Silencing Using Expressed Double Stranded Rna
  • Introducing A Molecule Capable Of Specifically Recognizing A Prostate Tumor Inducing Gene Into Cell Under Conditions Permitting Inhibition Of Expression Of Gene So As To Reverse Cancerous Phenotype Of The Cell
  • Imaging, Diagnosis And Treatment Of Disease
  • Functional Dna Clone For Hepatitis C Virus (Hcv) And Uses Thereof
  • Conformationally Constrained Parathyroid Hormone (Pth) Analogs
  • Vectors Comprising Cpg Islands Without Position Effect Varigation And Having Increased Expression
  • Polypeptide Derivatives Of Parathyroid Hormone (Pth)
  • For Diagnosing Degenerative Disorders Characterized In Inappropriate Cell Proliferation Or Inappropriate Cell Death; Formonitoring The Progress Of Such Degenerative Disorders
  • Double-Stranded Oligonucleotides
  • Nucleotide Sequences Coding Nvelope Protein For Use In The Prevention Of Viral Diseases
  • Use Of Stem Cells To Generate Inner Ear Cells
  • Ex Vivo Gene Therapy Of Hiv Infection; Cd34+ Hematopoietic Cells Being Transduced With A Viral Construct Which Expresses An Anti-Hiv Agent
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Targeted Integration And Expression Of Exogenous Nucleic Acid Sequences
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • For Gene Therapy; Enhanced Targeting Potential; Chimeric Molecule Containing Heterologous Trimerization Motif And Receptor-Binding Ligand
  • Human Umbilical Cord Tissue Cells For Inhibiting Adverse Immune Response In Histocompatibility-Mismatched Transplantation
  • Fgf-21 Mutants Comprising Polyethylene Glycol And Uses Thereof
  • Lipoxygenase Proteins And Polynucleotides Encoding The Same
  • Methods And Compositions For The Inhibition Of Trpv4
  • Polypeptide Variants Of Sleeping Beauty Transposase
  • Nucleic Acid Compositions And Their Use Against The Hepatitic C Virus
  • High-Affinity Choline Transporter
  • Chimeric Adenoviruses
  • Agent For Inducing Apoptosis Comprising Msx1 Or A Gene Encoding The Same As An Active Ingredient
  • Methods Of Treating Retinitis Pigmentosa Using Nucleic Acids Encoding Rdcvf1 Or Rdcvf2
  • Method For Detecting Loss Of Wild-Type P53
  • Antibodies That Bind To Repulsive Guidance Molecule A (Rgma)
  • Treatment Of Immune Disease By Mucosal Delivery Of Antigens Using Genetically Modified Lactococcus
  • Fgf21 Mutants Comprising A Mutation At Position 98, 171 And/Or 180
  • Cell Permeable Peptides For Inhibition Of Inflammatory Reactions And Methods Of Use
  • Multimeric Forms Of Members Of The Steroid/Thyroid Superfamily Of Receptors With The Ultraspiracle Receptor
  • Epidermal Growth Factor
  • Delivering Viral Vectors To The Cns Are Provided.
  • Prostate-Specific Antigen
  • Anti-Cd98 Antibody Processes
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Composition And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis And Abnormal Cell Proliferation
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Variants Of Pigment Epithelium Derived Factor And Uses Thereof
  • Compositions For Targeted Gene Delivery
  • Use Of Vegf-C To Prevent Restenosis
  • Fibroblast Growth Factor-Like Polypeptides And Variants Thereof
  • Promoterless Cassettes For Expression Of Alpha Virus Structural Proteins
  • Mesothelin Vaccines And Model Systems
  • Differentiation Of Mutz-3 Cells To Produce Effective Dendritic Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Methods Of Treating Retinal Nerve Fiber Layer Degeneration With Monoclonal Antibodies Against A Retinal Guidance Molecule (Rgm) Protein
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • A Nucleotide Sequence Capable Of Encoding An Antibody In Vivo
  • Vectors For Gene Delivery
  • Cartilage And Bone Repair And Regeneration Using Postpartum-Derived Cells
  • Modulating Cellular Senescence In Vitro By Introducing A Polynucleotide (Gdna Or Cdna) Encoding An Amphiphysin-1 Protein; Genetic Engineering; Genetic Disorders, Premature Aging
  • Novel Inducible Animal Models Of Stress Behavior
  • Ultrasound Catheter
  • Methods And Compositions For Promoting Survival And Proliferation Of Endothelial Cells And Stimulating Angiogenesis
  • Polynucleotide Or Complement Comprising Nucleic Acid Sequence Flanked By First And Second Inverted Repeats
  • Alternating Modeling Of Chromatin In Cells; Genetic Engineering
  • Compositions And Methods For The Therapy And Diagnosis Of Prostate Cancer
  • Methods And Means For Obtaining Modified Phenotypes
  • Use Of Hyaluronan In Gene Therapy
  • Gene Repair Involving In Vivo Excision Of Targeting Dna
  • Cell Targeting Vectors Containing A Dna Sequence Encoding A Single Chain Antibody Fragment Having A Specific Amino Acid Sequence And May Further Contain A Dna Sequence Encoding A Spleen Necrosis Virus Env Leader; Used In Particular For The Therapy Of T-Cell-Associated Diseases.
  • Induction Of Immune Response To Antigens Expressed By Recombinant Adeno-Associated Virus
  • Screening Methods Using G-Protein Coupled Receptors And Related Compositions
  • Methods And Compositions To Induce Antitumor Response
  • Methods Of Stimulating Phagocytosis
  • Osteoactivin Protein And Nucleic Acids Encoding The Same, Compositions And Methods Of Stimulating Bone Differentiation
  • Control Of Gene Expression In Eukaryotic Cells
  • Liposomes Containing Therapeutic Genes Are Conjugated To Targeting Agents To Provide Transport Of Encapsulated Gene Across Blood-Retainal Barrier And Plasma Membrane Of Ocular Cell, Where This Gene Expresses Encoded Therapeutical Agent
  • Means And Methods For Nucleic Acid Delivery Vehicle Design And Nucleic Acid Transfer
  • Using A Nucleic Acid Capable Of Expressing Beta-Interferon; Treating Demyelinating Disease Such As Multiple Sclerosis
  • Bioconjugates And Delivery Of Bioactive Agents
  • Isolated Monoclonal Anti-Repulsive Guidance Molecule A Antibodies And Uses Thereof
  • Influenza Virus Replication For Vaccine Development
  • Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter
  • Glutamic Acid Decarboxylase (Gad) Based Delivery System
  • Methods And Compositions For Treating Inflammatory Conditions
  • Comprise Monoclonal/Polyclonal Antibodies Against Cell Death Protein For Use In Preventing And Treating Degenerative Disorders Characterized By Inappropriate Cell Death/Proliferation; Antiproliferative/Antiapoptosis
  • Use Of A Polypeptide As Cell Receptor For Adenoviruses
  • Adenoviral Vector Encoding Human Atonal Homolog-1 (Hath1)
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Pharmaceutical Composition Containing A Stabilised Mrna Optimised For Translation In Its Coding Regions
  • Methods For Administration Of Recombinant Gene Delivery Vehicles For Treatment Of Hemophilia And Other Disorders
  • Selective Induction Of Apoptosis To Treat Ocular Disease By Expression Of Pedf
  • Cell Lines
  • Diffusion Of Gases, Nutrients Into Micro-Organs; Culture; Cell Proliferation
  • Methods Of Increasing Rdcvf 1 Or Rdcvf 2 Polypeptides In Retinal Cells
  • Isolated Nucleic Acid Encoding Mucosa-Associated Lymphoid Tissue Malt-Lymphoma Associated Translocation (Mlt) Protein Comprising Specified Amino Acid Sequence
  • Using Artificial Bacterial Chromosome And Homologous Recombination As Tools For Stable Transfer Of Genetic Material Into Cells; Gene Replacement; Transgenic Animal Models
  • Expression Vector; For Use As Tool In Genetic Engineering And Gene Therapy
  • Method For Providing Phototherapy To The Brain
  • Conformationally Constrained Parthyroid Hormone (Pth) Analogs
  • P101 Polypeptides
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Methods And Means For Obtaining Modified Phenotypes
  • Genetic Correction Of Mutated Genes
  • Lentiviral Vectors
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Oxidized Lipids And Uses Thereof In The Treatment Of Inflammatory Diseases And Disorders
  • Ablation Of The Skin With An Electric Current From Treatment Electrodes, Then Using Iontophoresis, Electroosmosis, Iontophoresis, Electroporation, Phonophoresis, Pressure, Heat And/Or Concentration Gradients, To Move Drugs Through The Skin Or Mucous Membranes
  • Neublastin Variants
  • Neurotransmitter Transporter Sc6
  • Infectivity-Enhanced Conditionally-Replicative Adenovirus And Uses Thereof
  • Microorganisms For Therapy
  • Antibodies To Human Β-Adrenergic Receptor Kinase
  • For Generating An Immune Response In A Subject; Synthetic Expression Cassettes Generated From These And Other Hiv Sequences; Vaccines; Immunogenic Hiv Gag Polypeptide
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • In Vivo Production Of Proteins
  • Humanized Low Affinity Fcγr Mouse Cells
  • Vaccinia Virus For Diagnosis And Therapy Of Tumors
  • 3-Allyl-Rapamycin, 3-Methallyl-Rapamycin; C3-Substituted Rapamycin Rapalogs; Multimerizing Chimeric Proteins In Engineered Cells; Reduced Immunosuppressive Effect; Gene Therapy; Form A Tripartite Complex With Fkbp12 And A Genetically Engineered Frb Domain, Or Fusion Proteins Having Fkbp And Frb Domains
  • Modified Virus Vectors And Methods Of Making And Using The Same
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Human Plasma Hyaluronidase
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • Administering, In Vivo, At Or Around The Site Of The Solid Tumor, A Nucleic Acid Which Encodes An Ip-10 Polypeptide, For Inhibiting A Solid Tumor In A Mammal
  • Modulating Cellular Senescence In Vitro By Introducing A Polynucleotide (Gdna Or Cdna) Encoding An Amphiphysin-1 Protein; Genetic Engineering; Genetic Disorders, Premature Aging
  • Novel Inducible Animal Models Of Stress Behavior
  • Treatment Of Lung And Pulmonary Diseases And Disorders
  • Postpartum Cells Derived From Umbilical Tissue And Methods Of Making And Using The Same
  • Suppressor Of Ap-1
  • Methods For Enhanced Retroviral-Mediated Gene Transfer
  • Administering At Site Of Excessive Vascular Smooth Muscle Cell Proliferation, An Isolated Human Gata-6 Nucleic Acid, To Reduce Or Prevent Excessive Vascular Smooth Muscle Cell Proliferation At The Site In Vivo; Treating Atherosclerosis
  • A Genetic Construct Containing A Glucose Inducible Regulatory Element With A Pair Of Cacgtg Nucleotide Sequences And Confer Human Proinsulin Expression In Host Hepatocyte Cells; Therapy For Diabetes
  • Cancer Treatment With Endothelin Receptor Antagonists
  • Vectors For Gene Delivery
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Poliovirus Replicons Encoding Therapeutic Agents And Uses Thereof
  • Neurotrophic Factors And Methods Of Use Thereof
  • Methods And Compositions For The Treatment Of Lysosomal Storage Diseases
  • Gene Delivery System
  • Vector Systems And Kits Using A Serotype Specific Strategy For Making Adenoviral Vector Preparations Substantially Free Of Replication Competent "Helper" Virus; For Use In Gene Transfer And Gene Therapy
  • Gene Therapy For Inhibition Of Angiogenesis
  • Compositions And Methods For Non-Targeted Activation Of Endogenous Genes
  • Tubulin; Inhibitor Of Cell Proliferation; For Drug Screening
  • Expression Vectors And Recombinant Virions Produced Using These Vectors, Which Include Genes Coding For Enzymes Defective Or Missing In Lysosomal Storage Disorders, Are Described. These Recombinant Aav Virions Are Useful In The
  • Adeno-Associated Virus Capable Of Expressing Factor Ix Protein And Cells Comprising The Same
  • Novel Nucleic Acid Molecules; Immunospecifically Binding Respiratory Syncytial Virus (Rsv) Antigens; Long Half Life; Reduced Dosage And Side Effects
  • Methods For Introducing Genes Into Mammalian Subjects
  • Synthetic Genes And Genetic Constructs Comprising Same I
  • Rna Interference Mediating Small Rna Molecules
  • C-Reactive Protein (Crp); Peptide Biodrugs Used To Reduce Body Weight, Adiposity, And Alleviate Insulin Resistance And Diabetes
  • Murb
  • Human Cytokine Polypeptide
  • Methods Of Gene Therapy Using Herpes Viral Vectors Expressing Gm-Csf
  • Nucleotide Sequence Which Encodes G-Protein Coupled Receptor; For The Treatment And Prevention Of Bacterial, Fungal, Protozoan And Viral Infections; For Use In Gene Therapy
  • Methods And Compounds For Controlled Release Of Recombinant Parvovirus Vectors
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Cell Lines
  • Method Of Reducing Neuronal Electrical Activity With A Potassium Channel Subunit
  • Lipoproteins As Nucleic Acid Vectors
  • Precise Homologous Recombination-Mediated Gene Repair Via Use Of Chimeric Restriction Endonucleases
  • A Genetic Construct Containing A Glucose Inducible Regulatory Element With A Pair Of Cacgtg Nucleotide Sequences And Confer Human Proinsulin Expression In Host Hepatocyte Cells; Therapy For Diabetes
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Vascular Endothelial Growth Factor 2
  • Ultrasound Catheter
  • Methods And Compositions For Promoting Survival And Proliferation Of Endothelial Cells And Stimulating Angiogenesis
  • Methods For Administration Of Recombinant Gene Delivery Vehicles For Treatment Of Hemophilia And Other Disorders
  • Ablation Of The Skin With An Electric Current From Treatment Electrodes, Then Using Iontophoresis, Electroosmosis, Iontophoresis, Electroporation, Phonophoresis, Pressure, Heat And/Or Concentration Gradients, To Move Drugs Through The Skin Or Mucous Membranes
  • Neublastin Variants
  • C-Reactive Protein (Crp); Peptide Biodrugs Used To Reduce Body Weight, Adiposity, And Alleviate Insulin Resistance And Diabetes
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Human Cytokine Polypeptide
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Poliovirus Replicons Encoding Therapeutic Agents And Uses Thereof
  • Neurotrophic Factors And Methods Of Use Thereof
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Adeno-Associated Virus Capable Of Expressing Factor Ix Protein And Cells Comprising The Same
  • Novel Nucleic Acid Molecules; Immunospecifically Binding Respiratory Syncytial Virus (Rsv) Antigens; Long Half Life; Reduced Dosage And Side Effects
  • Methods For Introducing Genes Into Mammalian Subjects
  • Tubulin; Inhibitor Of Cell Proliferation; For Drug Screening
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Expression Of Fusion Proteins
  • Method Of Differentiating Umbilical Cord Tissue Into A Chondrogenic Phenotype
  • Trp8, A Transient Receptor Potential Channel Expressed In Taste Receptor Cells
  • Therapy For Nervous System Degradation
  • Genetic Adjuvants For Immunotherapy
  • Interleukin-12 As An Adjuvant For Paramyxoviridae Vaccines
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Immunotherapy Regimes Dependent On Apoe Status
  • Secreted Proteins
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Enhancer From Immunoglobulin; Polyadenylation Site; Gene Therapy
  • Cytokines And Neuroantigens For Treatment Of Immune Disorders
  • Novel Nucleic Acid Molecules; Immunospecifically Binding Respiratory Syncytial Virus (Rsv) Antigens; Long Half Life; Reduced Dosage And Side Effects
  • Rna Interference Mediating Small Rna Molecules
  • High Potency Sirnas For Reducing The Expression Of Target Genes
  • Preventing Airway Mucus Production By Administration Of Egf-R Antagonists
  • Methods And Means For Obtaining Modified Phenotypes
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Bovine Adeno-Associated Viral (Baav) Vector And Uses Thereof
  • Preparing A Suppression Effector And Replacement Nucleic Acid That Have Modifications In One Or More Third Base (Wobble) Positions So That Replacement Nucleic Acids Still Code For The Wild Type Or Equivalent Amino Acids
  • Compositions And Methods For Treating Diseases
  • Gene Transfer Into Airway Epithelial Stem Cell By Using Lentiviral Vector Pseudotyped With Rna Virus Or Dna Virus Spike Protein
  • Polynucleotide
  • Isolated Human Cell With An Inactivated Glucocorticoid Receptor Gene
  • Control Of Gene Expression
  • Stimulating Formation Of An Inner Ear Sensory Hair Cell For Treatment Of Sensorineuronal Hearing Loss; Deafness
  • Screening Method For Compounds That Promote Differentiation Of Inner Ear Progenitor Cells
  • Methods And Compositions For Genomic Modification
  • Prostate Cancer Prognostic Compositions And Kits
  • Method For Treating Cancer, Visualizing Cell Structures, And Isolating Organelles Using Organelle Crystallizing Agents
  • Transferring Nucleotide Sequences To Cells; Obtain Cells, Incubate With Delivery Agent, Expose To Nucleotide Sequences, Recover Transform Cells
  • Supplying Nucleic Acids To Cells Being Grafted
  • Manganese Superoxide Dismutase Exon 3-Deleted Isoforms And Nucleic Acid Molecules Encoding The Isoforms
  • Using A Tyrosine Kinase Receptor Inhibitor
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Targeted Gene Modification By Parvoviral Vectors
  • Providing A Population Of Pluripotent Hematopoetic Cells, Expanding Population Of Stem Cells To Yield Expanded Stem Cells, Inducing A Majority Of Cells In The Population Of Expanded Cells To Become Quiescent, Using Quiescent Cells
  • Expression Vector Having Structural Gene Linked To Chimeric Promoter Including Repressor Element Of Defined Nucleotide Sequence And Other Regulatory Sequences; Specific Delivery Of Anticarcinogenic/Antitumor/Antiproliferative Agents
  • Compositions And Methods For Modulating Vascularization
  • Nucleic Acid Sequence Which, When Generates Mrna Which Anneals With Mrna Stranscrip From Hiv-1 Provirus Encoding Env, Pol, And/Or Gag Proteins
  • Conformationally Constrained Parathyroid Hormones With Alpha-Helix Stabilizers
  • In Vivo Stimulation Of Angiogenic Activity
  • Mixture Of Gene Of Interest And Estradiol; For Efficient Targeted Non-Viral Gene Therapy Of Cytotoxic Genes, Prodrug Activators, Antimetastasis Agents, And Immune Surveillance Genes; For Anticarcinogenic/Antitumor Agents
  • Fgf21 Mutant Fusion Polypeptides And Uses Thereof
  • Administering Replication-Defective Viral Vectors Comprising Genes That Codes For Glycoproteins; Gene Therapy
  • Fibroblast Growth Factor-Like Polypeptides
  • Using Adenoviral Transformation/Transfection To Transfer Cyclin And Cyclin Dependent Kinase Genes Into Nucleus Of Differentiated Cells; Regenerative Medicine And Tissue Engineering
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Derived From The Murine Leukemia Virus, Comprises Elongation Factor-Alpha; For Gene Therapy
  • Modified Factor Viii
  • Method To Detect Prostate Cancer In A Sample
  • Modalities For The Treatment Of Degenerative Diseases Of The Retina
  • Rna Interference Mediating Small Rna Molecules
  • Defective Platelet Activation In Gαq Deficient Mice
  • Methods And Compositions For Treatment Of Interferon-Resistant Tumors
  • Attenuated Influenza Ns1 Variants
  • Gene Delivery System And Methods Of Use
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Diagnosis And Treatment Of Myocardial Failure
  • Methods For Producing And Using In Vivo Pseudotyped Retroviruses Using Envelope Glycoproteins From Lymphocytic Choriomeningitis Virus (Lcmv)
  • Alphavirus Cdna Vectors
  • Anticancer Agents
  • For Developing Products Useful In Neuronal Regeneration And In Treatment Of Various Neurological Disorders, Including Dns Tumor
  • Inhibitors Of Cyclin-Dependent Kinases (Cdks), Particularly Cdk/Cyclin Complexes, Can Be Used To Control Proliferation And/Or Differentiation Of Cells
  • Transgene Expression System For Increased Persistence
  • Administration Of An Effective Amount Of Nucleic Acid Molecules Encoding Interleukin-12 (Il-12), Interferon-Gamma (Ifn- Gamma ), And A Cytomegalo Virus Promoter Sequence To A Patient Suffering From Allergy, Atopic Dermatitis, Asthma, Allergic Sinusitis, Pulmonary Fibrosis, And Cancer.
  • Porcine Adenovirus E1 And E4 Regions
  • Methods And Compositions For Treating Hypercholesterolemia
  • Nucleic Acid Sequence For Potentiating The Expression Of Useful Gene And Method Therefor
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Thrombopoietic Compounds
  • Methods And Compositions For Modulating Pd1
  • Therapy For Brain Disorders
  • Stable Formulations Of Purified Proteins
  • Entomopoxvirus-Vertebrate Gene Delivery Vector And Method
  • Recombinant Adenovirus Helper-Dependent Vector With Adenovirus Inverted Terminal Repeat Sequences, At Least One Recombination Site, And Adenovirus Packaging Sequence, And Exogenous Dna To Be Expressed; Simple And Efficient Production
  • Ultrasound Catheter For Providing A Therapeutic Effect To A Vessel Of A Body
  • Method And Compounds For Controlling Capacitative Calcium Ion Entry Into Mammalian Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Transgene Expression System For Increased Persistence
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Thrombopoietic Compounds
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Uses For Nucleic Acid Molecules In Detecting The Presence Of Pneumococcal Surface Protein C Or Of S.Pneumoniae By Detecting A Nucleic Acid Molecule Therefor In A Sample Such As By Amplification And/Or A Polymerase Chain Reaction
  • Anti-Cd98 Antibody Processes
  • Dna Libraries; Genetic Engineered Nucleic Acids
  • Human Embryonic Kidney Cells And Amniocytes; Capable Of Complementing Recombinanat Adenovirus
  • Nucleic Acid Compositions For Stimulating Immune Responses
  • Insertion Target Ligands Into Proteins; Detection Fluorescent Signals; Determination, Calibration; Gene Therapy; Antitumor Agents
  • Ultrasound Catheter For Providing A Therapeutic Effect To A Vessel Of A Body
  • Method And Compounds For Controlling Capacitative Calcium Ion Entry Into Mammalian Cells
  • Recombinant Adenovirus Helper-Dependent Vector With Adenovirus Inverted Terminal Repeat Sequences, At Least One Recombination Site, And Adenovirus Packaging Sequence, And Exogenous Dna To Be Expressed; Simple And Efficient Production
  • Repair And Regeneration Of Renal Tissue Using Human Umbilical Cord Tissue-Derived Cells
  • Methods For The Modulation Of Neovascularization And/Or The Growth Of Collateral Arteries And/Or Other Arteries From Preexisting Arteriolar Connections
  • Methods Employing And Compositions Containing Defined Oxidized Phospholipids For Prevention And Treatment Of Atherosclerosis
  • Defective Platelet Activation In Gαq Deficient Mice
  • Methods And Compositions For Treatment Of Interferon-Resistant Tumors
  • Adenovirus Vectors Containing Cell Status-Specific Response Elements And Methods Of Use Thereof
  • Targeted Gene Delivery To Dendritic Cells
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Rna Interference Mediating Small Rna Molecules
  • Carcinoma-Related Genes And Polypeptides And Methods Of Use Thereof
  • Influenza B Virus Replication For Vaccine Development
  • Transcriptional Activators, And Compositions And Uses Related Thereto
  • Gene Therapy For Neurodegenerative Disorders
  • Applying Wound Healing Agents Comprising Nucleotide Sequences Codes For Platelet Derived Growth Factors(Pdgf), Keratinocyte Growth Factors(Kgf), Insulin Like Growth Factors(Igf) And Insulin Like Growth Factor Binding Proteins(Igfbp)
  • Fot Treatment Of Disorders Of Bone Cartilage Or Lung Defect (Such As Osteoporosis And Cycstic Fibrosis) Via Transfection Comprising Herpes Thymidine Kinase Gene
  • J Chain Or Portion Thereof Linked To At Least One Enzyme Inhibitor; Specifically Binds To Basolateral Factor; Eradi-Cation Of Metastatic Or Nonpolarized Cells; Lung, Breast, Colon, Ovarian And Prostate Carcinoma And Endometriosis
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Expression Of Fusion Proteins
  • Isolated Human Cell With An Inactivated Glucocorticoid Receptor Gene
  • Control Of Gene Expression
  • Stimulating Formation Of An Inner Ear Sensory Hair Cell For Treatment Of Sensorineuronal Hearing Loss; Deafness
  • Fibroblast Growth Factor-Like Polypeptides
  • Using Adenoviral Transformation/Transfection To Transfer Cyclin And Cyclin Dependent Kinase Genes Into Nucleus Of Differentiated Cells; Regenerative Medicine And Tissue Engineering
  • Cytokines And Neuroantigens For Treatment Of Immune Disorders
  • Gene Delivery System And Methods Of Use
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Diagnosis And Treatment Of Myocardial Failure
  • For Developing Products Useful In Neuronal Regeneration And In Treatment Of Various Neurological Disorders, Including Dns Tumor
  • Inhibitors Of Cyclin-Dependent Kinases (Cdks), Particularly Cdk/Cyclin Complexes, Can Be Used To Control Proliferation And/Or Differentiation Of Cells
  • Adenoviral Vector Encoding Anti-Apoptotic Bcl-2 Gene And Uses Thereof
  • Compositions, Systems And Methods For Cell Therapy
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Genes Involved In A Variety Of Cellular Processes, Including Retinal Degeneration, Cancer, Memory And Learning, And Identification Of The Function Of A Variety Of Genes And Gene Fragments Of Unknown Function
  • Expression Of Fusion Proteins
  • Production System For Producing Lentivirus-Based, Replication Defective Vector Particles For Gene Therapy
  • Ob Fusion Protein Compositions And Methods
  • Pharmaceutical Composition Containing A Stabilised Mrna Optimised For Translation In Its Coding Regions
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Methods And Means For Obtaining Modified Phenotypes
  • Rna Interference Mediating Small Rna Molecules
  • High Potency Sirnas For Reducing The Expression Of Target Genes
  • Administering Replication-Defective Viral Vectors Comprising Genes That Codes For Glycoproteins; Gene Therapy
  • Attenuated Influenza Ns1 Variants
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Enhancer From Immunoglobulin; Polyadenylation Site; Gene Therapy
  • Methods For Producing And Using In Vivo Pseudotyped Retroviruses Using Envelope Glycoproteins From Lymphocytic Choriomeningitis Virus (Lcmv)
  • Alphavirus Cdna Vectors
  • Anticancer Agents
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Modified Zinc Finger Binding Proteins
  • Compositions And Methods For Increasing Vascularization
  • Nucleic Acid Compositions For Stimulating Immune Responses
  • Modified Virus Vectors And Methods Of Making And Using The Same
  • Methods And Means For Obtaining Modified Phenotypes
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Immunoaffinity Purification
  • Combination Of Dna Damaging Factors With The Heterologous Expression Of A Tumor Suppressor Gene Lead To A Pronounced Synergy Over And Above The Actions Of The Individual Components
  • Targeted Integration And Expression On Exogenous Nucleic Acid Sequences
  • Genetic Engineered Adeno-Associated Virus(Aav) Genetic Vectors Comprising Inverted Terminal Repeats Having Nucleotides Sequence Deletions And Replacements; Polynucleotides Used For Prophylaxis Of Liver Disorders
  • Compositions And Methods For Non-Targeted Activation Of Endogenous Genes
  • Helper Dependent Adenoviral Vectors Encoding Erythropoietin Provide High Levels Of Epo To Achieve A Long-Term Therapeutically Effective Dosage, And Allow For Repeat Administration To Patients With Disorders Such As Anaemia Of
  • Anaerobic Bacterium As A Drug For Cancer Gene Therapy
  • Which Effect P53 Binding/Inactivation; Enhances Efficacy Of Such Viruses For Treating Cancer; Liposomes
  • Catheter With Multiple Ultrasound Radiating Members
  • Antisense Modulation Of Ptp1b Expression
  • Human Plasma Hyaluronidase
  • I-Crei Derived Single-Chain Meganuclease And Uses Thereof
  • Nano-Enhanced Optical Delivery Of Exogenous Molecules To Cells And Tissues
  • Bovine Adenovirus Type 3 Genome And Vector Systems Derived Therefrom
  • Methods And Compositions For Modulating Pd1
  • Peptide Compositions And Their Use Against The Hepatitis C Virus
  • Gene Therapy For Tumors Using Minus-Strand Rna Viral Vectors Encoding Immunostimulatory Cytokines
  • Nucleic Acid Molecules Comprising A Neocentromere
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Osteoactivin Protein And Nucleic Acids Encoding The Same, Compositions And Methods Of Stimulating Bone Differentiation
  • Expression Vector Coding Polypeptides For Use In The Treatment Of Alzheimer's Dieases And Tumors
  • Nucleotide Sequences Comprising An Inverted Terminal Duplication And Heterologous Nucleotide Sequences; For The Treatment Of Genetic Disorders And Gene Therapy
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Submitting Cell To An Anti-Apoptotic Treatment With An Agent Comprising R1 Subunit Of Herpes Simplex Virus Ribonucleotide Reductase Enzyme Or A Nucleic Acid Encoding Said Enzyme To Prevent Apoptosis In Vitro
  • A Dna Vector Delivery System Consisting Of A Cochleate Containing A Lipid Bilayer Element And Cations, Intergrative Proteins And Therapeutic Nucleotide Sequences; For Gene Therapy By Transducing Hematopoietic Stem Cells
  • A Pseudotyped Feline Immunodeficiency Virus Virion; Transfection; Expression Vectors Packaged In Packaging Cells To Generate High Titer Recombinant Virus Stocks; Gene Therapy
  • Methods For Treating Inflammatory Bowel Disease
  • Prevention And Treatment Of Amyloidogenic Disease
  • Modified Multilayered Film
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Adenoviruses Expressing Heterologous Tumor-Associated Antigens
  • Inhibition Of Stat3 Signal Transduction For Human Cancer Therapy
  • Rsv-Specific Binding Molecule
  • Methods Useful For Generating Highly Mannosylated Pseudotyped Lentiviral Vector Particles Comprising A Vpx Protein
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Primary Product In Which The Small Subunit Is N-Terminal To The Large Subunit
  • Angiogenic Growth Factors For Treatment Of Peripheral Neuropathy
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Nucleic Acid Condensing Peptide, Nucleic Acid Condensing Peptide Set, Nucleic Acid Delivery Carrier, Nucleic Acid Delivery Method, Cell Production Method, Cell Detection Method And Kit
  • Method For Producing A Protein Of Interest In A Primate
  • Microorganisms Carrying A Tumor Antigen
  • Antibodies To Fibroblast Growth Factor-Like Polypeptides
  • Rapid In Vivo Identification Of Biologically Active Nucleases
  • A Replication-Competent Adenovirus Vector Comprising An Adenovirus Gene Under Transcriptional Control Of A Probasin Transcriptional Regulatory Element(Pb-Tre)
  • Comprising Adeno-Associated Virus Terminal Repeat Sequences; Intrastrand Base-Pairing
  • Repair And Regeneration Of Ocular Tissue Using Postpartum-Derived Cells
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Lentiviral Vectors Pseudotyped With A Sindbis Virus Envelope Glycoprotein
  • Methods Of Treating Of Diabetes And Obesity Using Fgf21 Mutants
  • Adjustment Of Gene Expression
  • Dna Containing Variant Frt Sequences
  • P. Gingivalis Vaccine
  • Isolated Nucleic Acid Molecules Encoding A Herpesviridae Thymidine Kinase Enzyme Comprising One Or More Mutations, At Least One Of The Mutations Encoding An Amino Acid Substitution Upstream From A Drh Nucleoside Binding Site Which Increases A
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Modified Zinc Finger Binding Proteins
  • Compositions And Methods For Increasing Vascularization
  • Compositions And Methods For Non-Targeted Activation Of Endogenous Genes
  • Helper Dependent Adenoviral Vectors Encoding Erythropoietin Provide High Levels Of Epo To Achieve A Long-Term Therapeutically Effective Dosage, And Allow For Repeat Administration To Patients With Disorders Such As Anaemia Of
  • Methods And Means For Obtaining Modified Phenotypes
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Modified Virus Vectors And Methods Of Making And Using The Same
  • Anaerobic Bacterium As A Drug For Cancer Gene Therapy
  • Catheter With Multiple Ultrasound Radiating Members
  • Which Effect P53 Binding/Inactivation; Enhances Efficacy Of Such Viruses For Treating Cancer; Liposomes
  • Porcine Cells Comprising An Adenovirus E3 Gene Region
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Polynucleotides Encoding A Super-Active Porcine Growth Hormone Releasing Hormone Analog
  • Compositions And Methods For Sensitizing And Inhibiting Growth Of Human Tumor Cells
  • Nucleic Acid Compositions For Stimulating Immune Responses
  • Immunoaffinity Purification
  • Combination Of Dna Damaging Factors With The Heterologous Expression Of A Tumor Suppressor Gene Lead To A Pronounced Synergy Over And Above The Actions Of The Individual Components
  • Targeted Integration And Expression On Exogenous Nucleic Acid Sequences
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Herpes Simplex Virus (Hsv) Comprising Deletion, Insertion, Or Substitution In Each Gamma 34.5 Gene; Lysis
  • Genetic Engineered Adeno-Associated Virus(Aav) Genetic Vectors Comprising Inverted Terminal Repeats Having Nucleotides Sequence Deletions And Replacements; Polynucleotides Used For Prophylaxis Of Liver Disorders
  • Compositions And Method For Non-Targeted Activation Of Endogenous Genes
  • Modified Cytomegalovirus, The Modifications Include Adding Heterologus Sequence Enconding A Non-Viral Chemokine Element And/Or Immunogenic Polypeptide, And/Or Diabling A Viral Dissemination Gene
  • Duplexed Parvovirus Vectors
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Human Β-Adrenergic Receptor Kinase Polypeptide And Methods
  • Bioactive Peptides And Peptide Derivatives Of Parathyroid Hormone (Pth) And Parathyroid Hormone-Related Peptide (Pthrp)
  • Osteopontin-Related Compositions And Methods
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Antibody Constant Region Fused To An Ob Protein; Ditetics; Useful For Decreasing The Amount Of Insulin Necessary For The Treatment Of Diabetes
  • Stable Lipid-Comprising Drug Delivery Complexes And Methods For Their Production
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Compositions And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis, And Abnormal Cell Proliferation
  • Thrombopoietic Compounds
  • Preferential Translation Of Toxin; Anticancer Agents
  • Methods And Compositions For Inhibition Of Viral Replication
  • Submitting Cell To An Anti-Apoptotic Treatment With An Agent Comprising R1 Subunit Of Herpes Simplex Virus Ribonucleotide Reductase Enzyme Or A Nucleic Acid Encoding Said Enzyme To Prevent Apoptosis In Vitro
  • A Dna Vector Delivery System Consisting Of A Cochleate Containing A Lipid Bilayer Element And Cations, Intergrative Proteins And Therapeutic Nucleotide Sequences; For Gene Therapy By Transducing Hematopoietic Stem Cells
  • A Pseudotyped Feline Immunodeficiency Virus Virion; Transfection; Expression Vectors Packaged In Packaging Cells To Generate High Titer Recombinant Virus Stocks; Gene Therapy
  • Methods For Treating Inflammatory Bowel Disease
  • Prevention And Treatment Of Amyloidogenic Disease
  • Nucleotide Sequences Comprising An Inverted Terminal Duplication And Heterologous Nucleotide Sequences; For The Treatment Of Genetic Disorders And Gene Therapy
  • Self-Replicating; Capable Of Systemic Infection In A Host; Contain Nucleic Acid Sequences Foreign To The Native Virus Which Are Transcribed Or Expressed In The Host; And Stable For The Transcription And Expression Of Foreign Nucleic Acids
  • Methods And Compositions For Treating Abnormal Cell Growth Related To Unwanted Guanine Nucleotide Exchange Factor Activity
  • Gene Transfer Method
  • Pca3, Pca3 Genes, And Methods Of Use
  • Long Terminal Repeat Sequence Linkage With Heterologous Dna And A Packaging Cell Line, For Infecting And Directing The Expression In The Selected Target Cells; Side Effect Reduction; Coding Melittin, Cecropin, Magainin As Antitumour, Antiviral, Antibacterial, Antifungal Agents; Biodrugs
  • Transgenic Human Cells Expressing Superantigens/Antiproliferative Agents For Use As Gene Therapeutic Tools In Cancer Treatment ; Tissue Engineering
  • Ace2 Activation For Treatment Of Heart, Lung And Kidney Disease And Hypertension
  • Lipid Complex; Drug Delivery; Gene Therapy
  • Osteoactivin Protein And Nucleic Acids Encoding The Same, Compositions And Methods Of Stimulating Bone Differentiation
  • Expression Vector Coding Polypeptides For Use In The Treatment Of Alzheimer's Dieases And Tumors
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Modified Multilayered Film
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Antibody Glycosylation Variants Having Increased Antibody-Dependent Cellular Cytotoxicity
  • Gene Transfer In Chickens By Introduction Of Dna Into Muscle In Ovo
  • Trp8, A Transient Receptor Potential Channel Expressed In Taste Receptor Cells
  • Stress-Phosphorylated Endoplasmic Reticulum Protein, Nogo B, For Therapy
  • Nucleotide Sequences For Use As Tool In Genetic Engineering And Control Of Gene Expression
  • Treatment Of Amyotrophic Lateral Sclerosis Using Umbilical Derived Cells
  • Regeneration And Repair Of Neural Tissue Using Postpartum-Derived Cells
  • Anionic Charge-Dynamic Polymers For Release Of Cationic Agents
  • Compositions And Methods For Promoting Or Inhibiting Angiogenesis
  • Inhibiting The Growth Of The Cancerous Cells By Administering Acetaminophen And A Vector Comprising A Promoter Operably Linked To A Polynucleotide Encoding A Cytochrome P450 To Convert The Acetaminophen To The Cytotoxic Metabolite, N-Acetylbenzoquinoneimine
  • Imunogenic A Beta Fragment Linked To Immunoglobulin Carrier To Form Conjugate; Adjuvant Comprising Antibodies To A Beta Fragment Enhances Immune Response; Alzheimer*S Disease Treatment
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • In Vivo Assay For Intravasation
  • Retinal Dystrophy-Associated Protein And Uses Thereof
  • Hair Follicle Dna Delivery System
  • Methods Of Preventing And Treating Respiratory Viral Infection Using Immunomodulatory Polynucleotide Sequences
  • Hybrid Compositions For Intracellular Targeting
  • Use Of Vegf-D Gene To Prevent Restenosis
  • Synthetic Genes And Genetic Constructs
  • Microorganisms For Therapy
  • Method Of Treating Skin Ulcers With Vectors Encoding Hepatocyte Growth Factor
  • Antibody Glycosylation Variants Having Increased Antibody-Dependent Cellular Cytotoxicity
  • Prostate Cancer Prognostic Compositions And Kits
  • Nucleotide Sequences Coding Low Density Lipoprotein Receptor-Related Protein 5 For Use As Tools In Diagnosis And Treatment Of Osteoporosis; High Bone Mass And Bone Disorders
  • Nucleotide Sequences Coding Polypeptide For Use In The Treatment Of Cancer
  • Adeno-Associated Viral Vector For Use As Heterologous Gene Transfer Agent
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Angiogenic Growth Factors For Treatment Of Peripheral Neuropathy
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Method For Producing A Protein Of Interest In A Primate
  • Nucleic Acid Condensing Peptide, Nucleic Acid Condensing Peptide Set, Nucleic Acid Delivery Carrier, Nucleic Acid Delivery Method, Cell Production Method, Cell Detection Method And Kit
  • Rna Interference Mediating Small Rna Molecules
  • Methods For Modulating Bone Formation And Mineralization By Modulating Krc Activity
  • Comprising Adeno-Associated Virus Terminal Repeat Sequences; Intrastrand Base-Pairing
  • Il-17 Receptor A Antigen Binding Proteins
  • Gene And Protein Relating To Hepatocellular Carcinoma And Methods Of Use Thereof
  • Compositions And Methods For Treating Pancreatic Cancer
  • Tryptophan Containing Low Molecular Weight Polylysine, For Use In Receptor-Mediated And Nonreceptor-Mediated Gene Delivery, Both In Vivo And In Vitro
  • Treating Biomaterial Using At Least One Electrical Field Generated By A First Voltage Pulse Which Is Terminated Once The Value For An Electrical Parameter Has Exceeded Or Dropped Below A Preset Limit; Successful Cell Treatment Can Be Ensured By Continuing The Terminated Voltage Pulse
  • Universal Gm-Csf Expressing Bystander Human K562 Cell Line
  • Synthetic Polymer Carrier Vehicle For Delivery Of Nucleic Acid To Target Cells In Biological Systems
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • A Dna Molecule Coding For A Gene That Has Anti-Apoptotic Effects; For Transfection Of Eukaryotic Cells Without Toxic Effects
  • Administering To Peripheral Neuron Cells A Neurotropic Viral (Herpes Simplex) Vector Which Contains Dna Sequence Linked To Lat Promoter; Expressing Beta -Glucuronidase In Brain
  • Compositions And Methods For Elimination Of Unwanted Cells
  • Molecular Characterization Of Chromosome Translocation T(11;18)(Q21;Q21) And Its Correlation To Carcinogenesis
  • Delivering A Vector Comprising A Nucleotide Sequence Encoding A Glutamic Acid Decarboxylase To The Target Site In The Central Nervous System; And Expressing The Gad In The Target Site
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulations Of Angiogenesis And Anticancer Therapy
  • Use Of Magnesium (Mg2+) For The Preparation Of A Therapeutic Composition For Transfection Of A Polynucleotide Into A Cell And Compositions Useful In Gene Therapy
  • Tumor Necrosis Factor Related Ligand
  • Membrane Active Polymers
  • Ribozyme Therapy For The Treatment Of Proliferative Skin And Eye Diseases
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Recombinant Retrovirus Pseudotyped With A E2 Alphavirus Glycoprotein
  • Prevention And Treatment Of Amyloidogenic Disease
  • Methods For Producing Soluble, Biologically-Active Disulfide-Bond Containing Eukaryotic Proteins In Bacterial Cells
  • Microorganisms For Therapy
  • Anti-Robo4 Antibodies And Uses Therefor
  • Homodimeric Protein Constructs
  • Immunogenic Peptides For The Treatment Of Prostate And Breast Cancer
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Recombiant Lentivirus Comprising An E2 Alphavirus Glycoprotein That Binds To Dc-Sign
  • Recombinant Adenovirus Using Liposome-Mediated Cotransfection And The Direct Observation Of A Cytopathic Effect In The Transfected Cells; Tumor Suppressor Gene
  • Compositions And Methods For Activating Genes Of Interest
  • Adenovirus Encoding Human Adenylylcyclase (Ac) Vi
  • Use Of Decorin For Increasing Muscle Mass
  • Therapeutic Retroviral Vectors For Gene Therapy
  • Detection Of Genetic Lesions Used To Diagnose And Treat Central Nervous System Disorders Such As Epilepsy, Spinocerebellar Ataxia, Anxiety, Depression, Age-Related Memory Loss, Migraine, Obesity, Parkinsons Disease Or Alzheimer's Disease; Or Cardiovascular Disorders
  • Activator Of G Protein Signaling, Or ?Ags?; Recombinant Expression Vectors Containing A Nucleic Acid Molecule Of The Protein/Nucleic Acid
  • Binding Domains Of Proteins Of The Repulsive Guidance Molecule (Rgm) Protein Family And Functional Fragments Thereof, And Their Use
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Immunologically Privileged Cells And Uses Thereof
  • Fgf21 Polypeptides Comprising Two Or More Mutations And Uses Thereof
  • Formulation And Delivery Of Plga Microspheres
  • Anti-Nucleolin Agent-Conjugated Nanoparticles
  • Methods For Treating Tweak-Related Conditions
  • Delivery Of Multiple Genes To Cells Using Plural Adeno-Associated Viral Vectors
  • Treatment Of Immune Disease By Mucosal Delivery Of Antigens Using Genetically Modified Lactococcus
  • Method Of Using An Adenoviral Vector Encoding A Retinoblastoma Protein To Treat Hyperproliferating Cells
  • Methods And Reagents For Modulating Tgf-Β Superfamily Signaling
  • Postpartum Cells Derived From Umbilical Cord Tissue, And Methods Of Making And Using The Same
  • Rsv Specific Binding Molecule
  • Methods Of Delivering A Physiologically Active Polypeptide To A Mammal
  • Self-Replicating Episomal Expression Vectors Conferring Tissue-Specific Gene Expression
  • Dna Binding Proteins That Are Modified Such That They Are Stable Under Non-Hypoxic As Well As Hypoxic Conditions
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Inducing A Reduced Lymphocyte Proliferative Response To A Major Histocomatibilty Complex (Mhc) Type Presented On An Human Embryonic Stem (Hes) Cell In A Subject; Induces A State Of Inflammatory Quiescence Or Immune Unresponsiveness, Which In Turn Enhances Engraftment Of The Stem Cells
  • Genetic Enginnering; Kits
  • Rsv-Specific Binding Molecule
  • Intracellular Inhibitors Of Gq Protein Signaling
  • Combination Viral-Based And Gene-Based Therapy Of Tumors
  • Polynucleotide
  • Pin1 As A Marker For Abnormal Cell Growth
  • Antibodies Binding To An Intracellular Prl-1 Or Prl-3 Polypeptide
  • Administration Of Adenoviral Vectors; Correcting Defective Chloride Ion Transporters; Cystic Fibrosis
  • Secreted Proteins
  • Nucleic Acid-Lipopolymer Compositions
  • Administration Of A Chemotherapeutic Agent And A Formulation Containing A Cationic Liposomes Which Consists Of Cationic Lipid, Phosphatidylcholine And Cholesterol And Having Encapsulated Therein An Oligonucleotide
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Stranded Rna Viruses And Process For The Production Of Such Viruses
  • Induction Of Mucosal Tolerance To Antigens
  • Duplexed Parvovirus Vectors
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Human Β-Adrenergic Receptor Kinase Polypeptide And Methods
  • Comprise The Gene Of Interest; And A Viral Capsid Or Envelope Carrying A Member Of A Specific Binding Pair, The Counterpart Of Which Is Not Directly Associated With The Surface Of The Target Cell; Use In Gene Therapy
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Herpes Simplex Virus (Hsv) Comprising Deletion, Insertion, Or Substitution In Each Gamma 34.5 Gene; Lysis
  • Gene Transfer In Chickens By Introduction Of Dna Into Muscle In Ovo
  • Nucleotide Sequences For Use As Tool In Genetic Engineering And Control Of Gene Expression
  • Stress-Phosphorylated Endoplasmic Reticulum Protein, Nogo B, For Therapy
  • Trp8, A Transient Receptor Potential Channel Expressed In Taste Receptor Cells
  • Gene Transfer Method
  • Ace2 Activation For Treatment Of Heart, Lung And Kidney Disease And Hypertension
  • Lipid Complex; Drug Delivery; Gene Therapy
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Compositions And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis, And Abnormal Cell Proliferation
  • Use Of Adenoviruses And Nucleic Acids That Code For Said Viruses
  • An Immunogeniclly Effective Amount Of A Nuclic Acid Encoding A Relevant Epitope Of A Desired Target Antigen Is Administered To The Infant.
  • Method Of Administering Porcine B-Domainless Fviii
  • Universal Gm-Csf Expressing Bystander Human K562 Cell Line
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Antibody To Secreted Polypeptide
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Microorganisms For Therapy
  • Thrombopoietic Compounds
  • Metabolically Activated Recombinant Viral Vectors And Methods For Their Preparation And Use
  • Cryptosporidium Hominis Genes And Gene Products For Chemotherapeutic, Immunoprophylactic And Diagnostic Applications
  • Combination Method For Treatment Of Cancer
  • Adenovirus E1b Shuttle Vectors
  • Introducing Ribonucleic Acid (Rna) Into Cell In An Amount Sufficient To Inhibit Expression Of Target Gene, Wherein Rna Comprises A Double-Stranded Structure With An Identical Nucleotide Sequence As Compared To Portion Of Target Gene
  • Methods Of Administering Porcine B-Domainless Fviii
  • Protein Which Does Not Hertero-Oligomerize With Native P53; Antitumor Agents
  • Recombinant Viruses In Frozen Or Liquid Form, In Which Infectious Viruses Are Preserved In An Aqueous Solution. The Recombinant Virus Suspension Comprises An Aqueous Sucrose Solution At A Concentration For Gene Therapy.
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Genetic Engineered Chimera Particles Comprising Capsids From Adeno-Associated Virus And Genome Inverted Terminal Repeat Sequences As Vectors For Supplying And Expressing Nucleotide Sequence In Cells
  • Used To Reduce Resistance Of Cancer Cells To Treatment With An Anticancer Drug That Generates Oxidative Stress
  • Induction Of Mucosal Tolerance To Antigens
  • Split Dose Administration
  • Sterilization; Contraceptives; Antitumor Agents; Viricides; Autoimmune Diseases
  • Complementing Cell Lines
  • Amyloid Peptide Inactivating Enzyme To Treat Alzheimer's Disease Peripherally
  • Targeted Chromosomal Genomic Alterations With Modified Single Stranded Oligonucleotides
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Nucleic Acids Encoding Modulators Of Body Weight
  • Targeted Nucleic Acid Sequence Alteration Using Cells And Cell-Free Extracts With Altered Levels Or Activities Of A Protein From The Rad52 Epistasis Group, The Mismatch Repair Group And/Or The Excision Repair Group
  • Into A Mammalian Parenchymal Cell, By Complexing A Polynucleotide With A Nonviral Vector, Amphipathic Compounds, Or Polymer, Inserting Into A Mammalian Vessel, Increasing The Permeability Of The Vessel; Use In Gene Therapy
  • Methods Of Inducing Regulated Pancreatic Hormone Production In Non-Pancreatic Islet Tissues
  • Microorganisms For Therapy
  • Stem Cell Beacon
  • Antisense Modulation Of Ptp1b Expression
  • Administering Antibody Or A Fragment Thereof That Binds To A Human Homolog Of Frizzled, To Inhibit The Proliferation Of Cancer Cells
  • Delivery Of Nucleic Acid Into Aquatic Animals
  • Administering Nucleic Acid To Stimunlate Immunology Response
  • Interferon Inducing Genetically Engineered Attenuated Viruses
  • Nanoparticle-Based Gene Delivery Systems
  • Osteopontin-Related Compositions And Methods
  • Isolation, Purification Nucleic Acids; Dna Amplification In Sampling
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Hiv Env Polypeptides
  • Modified Polynucleotides Encoding Aquaporin-5
  • Materials And Methods For Treatment Of Inflammatory And Cell Proliferation Disorders
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same
  • Method For The Diagnosis And Prognosis Of Malignant Diseases
  • Mammalian Cell Which Can Package A Recombinant Adeno-Associated Virus (Aav) Vector At High Efficiency To Produce High Titers Of Recombinant Viral Particles
  • Composition And Method For Production Of Transformed Cells
  • Compositions Comprising Polynucleotides Encoding Rdcvf1 Or Rdcvf2
  • Method Of Targeting Gene Delivery Using Viral Vectors
  • Mutations That Confer Genetic Stability To Genes In Influenza Viruses
  • Biodegradable Cationic Polymers
  • Transgenic Animals And Cell Lines For Screening Drugs Effective For The Treatment Or Prevention Of Alzheimer's Disease
  • Targeting Proteins To Deliver Therapeutic Or Diagnostic Reagents
  • Fgf21 Mutants And Uses Thereof
  • Complementing Cell Lines
  • Conditioned Media And Methods Of Making A Conditioned Media
  • Method To Detect Prostate Cancer In A Sample
  • Treating Brain Damage By Genetically Modifying Nestin-Positive Cells With C-Myc Oncogene; Differentiation; Stroke, Ischemia, Cerebral Palsy, Alzheimer's, Neurodegenerative Diseases, Dementia, Parkinson's, Huntington's Disease
  • Genetic Demonstration Of Requirement For Nkx6.1 And Nkx2.2 In Ventral Neuron Generation
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/38410

    DOI

    http://dx.doi.org/10.1038/38410

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9305836


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