Gene therapy - promises, problems and prospects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-09-18

AUTHORS

Inder M. Verma, Nikunj Somia

ABSTRACT

The concept behind gene therapy is simple — by delivering corrective genetic material to the cells of a patient the symptoms of disease can be alleviated. But seven years after the first clinical trials on gene therapy began, how far have we come? Gene therapy has not lived up to many of its promises, but the main problem has been in designing efficient delivery vehicles ('vectors'). Nonetheless, the prospects are good — by the year 2010, gene therapy may be as routine a practice as heart transplants are today. More... »

PAGES

239-242

Journal

TITLE

Nature

ISSUE

6648

VOLUME

389

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  • Regeneration And Repair Of Neural Tissue Using Postpartum-Derived Cells
  • Treatment Of Peripheral Vascular Disease Using Umbilical Cord Tissue-Derived Cells
  • Administering Nucleic Acid Molecule Encoding Retinoblastoma Protein-Interacting Zinc Finger Protein At Or Adjacent To Site Of Tumor, Wherein Protein Comprises Specified Amino Acid Sequence And Is Expressed In Tumor Cell And Reduces Its Growth
  • Mammalian Cell Lines Expressing Bovine Adenovirus Functions
  • Influenza M2 Protein Mutant Viruses As Live Influenza Attenuated Vaccines
  • Compositions And Methods For Polynucleotide Delivery
  • Detecting The Decreased Transcription Of Messenger Rna Transcribed From An Rdcvf1 Or Rdcvf2 Polypeptide, In The Eye Of A Human, Wherein Said Decreased Transcription Is Diagnostic Of Such Human's Suffering From Retinal Dystrohy
  • Recombinant Adenovirus Is Linked Via Streptavidin To A Biotinylated Targeting Moiety
  • Refolding Transforming Growth Factor Beta Family Proteins
  • Destruction Of The Epithelium Of An Exocrine Gland In The Prophylactic And Therapeutic Treatment Of Cancer
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Fgf 21 Polypeptides Comprising Two Or More Mutations And Uses Thereof
  • Method For Introducing A Molecule Into The Cytosol Of A Cell In Which The Cell Is Contacted With A Photosensitising Agent, The Cell Is Irradiated With Light Of A Wavelength Effective To Activate The Photosensitising Agent And, Substantially At The
  • Short Interfering Rnas For Use Treating Viral Diseases, Autoimmune Disease And Tumors; Double Stranded Rna
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Compounds And Methods To Enhance Raav Transduction
  • Medical Equipment Comprising Nucleic Acid Codes For Wild-Type Human Kinase Interacting Stathmin (Hkis) Phosphoproteins, Used For Drug Delivery; Antiproliferative Agents
  • Use Of Marrow-Derived Glial Progenitor Cells As Gene Delivery Vehicles Into The Central Nervous System
  • Tumor Suppressor Killin
  • Efficient Ex Vivo Expansion Of Cd4+ And Cd8− T-Cells From Hiv Infected Subjects
  • Light Emitting Microorganisms And Cells For Diagnosis And Therapy Of Diseases Associated With Wounded Or Inflamed Tissue
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Method For Modulating Expression Of Exogenous Genes In Mammalian Systems, And Products Related Thereto
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same
  • Administering Exogenous Genes
  • Defective Recombinant Adenovirus Comprising A Nucleic Acid Sequence Coding For A Biologically Active Human Lipoprotein Lipase
  • Il-17 Receptor A Antigen Binding Proteins
  • Synthetic Transfection Vectors
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Recombinant Protein Bodies As Immunogen-Specific Adjuvants
  • Covalent Coupled Of Nucleic Acids, Peptides Or Proteins To Active Material For Enhancing Transfection Efficiency; Potentiation
  • Antiedema Agents, Adenovirus Genomes, Nucleotide Sequences And Transferring Adenoviral Genetic Vectors
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Stress-Responsive Induction Of A Therapeutic Agent And Methods Of Use
  • Polyclonal Immunoglobulin For Use In Diagnosis, Prevention And Treatment Of Infection, Cell Proliferative, Blood, Autoimmune And Nervous System Disorders
  • The Polypeptide Activates One Or More Fgf Receptors, Regulates The Growth And Differentiation Of Cells Within The Liver, Regulates Other Cell Types Following Secretion From The Liver, Plays A Role In Liver Chemotaxis, Has An Oncogenic Activity, Or Serves As An Antigen For Generating Antibodies
  • Human Antigen Binding Proteins That Bind Β-Klotho, Fgf Receptors And Complexes Thereof
  • Nucleic Acid Molecules Encoding Fibroblast Growth Factor-Like Polypeptides
  • Neurotrophic Factors
  • Vascular Endothelial Growth Factor 2
  • Protein Encoded By The Nucleotide Sequence Represented By Seq Id No: 15; Useful For Diagnosing And Treating Cancer
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Prepared From Autologous Lymphoma Cells Transfected With Emm55; For Canines; The Modified Cancer Cells Are Highly Immunogenic To The Host, Yet Show No Toxic Side Effects
  • Prostate Cancer Prognostic Compositions And Kits
  • The Enzyme Maintains Methionine Synthase In Its Reduced, Activated State, And Hence Is An Essential Component Of The Methionine Synthetic Pathway.
  • Antibody Fragment-Targeted Immunoliposomes For Systemic Gene Delivery
  • Identifying Modulators Of Fibroblast Growth Factor-Like Polypeptides
  • Use Nf-Κb Inhibition In Combination Therapy For Cancer
  • Compositions And Methods For Angiogenic Therapy Utilizing Genes Encoding Ets-1
  • Peptide Inhibitors Of Iaspp
  • Compositions And Methods For Treating Pancreatic Cancer
  • Manf2 For Treatment Of Parkinson's Disease
  • Therapeutic Agent For Infections, And Treatment Method Using Same
  • Artificial Ubiquitous Chromatin Opening Elements (Ucoe)
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Designing Zinc Finger Binding Polypeptides For Binding To A Particular Target Sequence; Used In Modulation Of Expression Of A Disease-Associated Gene
  • 2786, A Novel Human Aminopeptidase
  • Comprises Regulatory Polypeptide Which Binds Kinase Interacting Polypeptide For Diagnosis, Prevention And Treatment Of Tumors And Alzheimer's Diseases
  • Neurotransmitter Transporter Sc6
  • Dna And Protein For The Diagnosis And Treatment Of Alzheimer's Disease
  • Lipid Complexes For Transferring At Least A Therapeutically Active Substance, In Particular A Polynucleotide Into A Target Cell And Use In Gene Therapy
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Chimeric Viruses Presenting Non-Native Surface Proteins And Uses Thereof
  • Method Of Treating Bone Disorders Using Tsg-6
  • Artificial Fusion Protein Has Been Designed Containing An Ldl Receptor Domain Attached To A Localization Domain Which Causes Retention Of The Fusion Protein Inside Of A Cell; Fusion Protein Is Preferably Retained In The Endoplasmic Reticulum Of The Cell, Where The Ldlr Can Degrade Apob
  • Transgenic Human Cells Expressing Antiproliferative Agents; Gene Therapy; Anticancer Agents; Tissue Engineering; Generating Immunology Response
  • Human Abc1 Promoter And Assays Based Thereon
  • Transducing Neuron With Gene; Muscular Disorders
  • Methods And Compositions For Genomic Modification
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Parathyroid Hormone Analogs And Uses Thereof
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Vascular Endothelial Growth Factor 2
  • Designing Zinc Finger Binding Polypeptides For Binding To A Particular Target Sequence; Used In Modulation Of Expression Of A Disease-Associated Gene
  • Artificial Ubiquitous Chromatin Opening Elements (Ucoe)
  • Prostate Cancer Prognostic Compositions And Kits
  • The Enzyme Maintains Methionine Synthase In Its Reduced, Activated State, And Hence Is An Essential Component Of The Methionine Synthetic Pathway.
  • Protein Encoded By The Nucleotide Sequence Represented By Seq Id No: 15; Useful For Diagnosing And Treating Cancer
  • Neurotrophic Factors
  • Vascular Endothelial Growth Factor 2
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Selectivity Replicating Viral Vector
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Compounds And Methods To Enhance Raav Transduction
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Tumor Suppressor Killin
  • Efficient Ex Vivo Expansion Of Cd4+ And Cd8− T-Cells From Hiv Infected Subjects
  • Fgf 21 Polypeptides Comprising Two Or More Mutations And Uses Thereof
  • Short Interfering Rnas For Use Treating Viral Diseases, Autoimmune Disease And Tumors; Double Stranded Rna
  • Therapy For Cellular Accumulation In Chronic Inflammatory Diseases
  • Recombinant Adenovirus Is Linked Via Streptavidin To A Biotinylated Targeting Moiety
  • Synthetic Transfection Vectors
  • Il-17 Receptor A Antigen Binding Proteins
  • Modified Polynucleotides Encoding Cited4
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Polymer Conjugates Of Mutated Neublastin
  • Polynucleotides For Reducing Respiratory Syncytial Virus Gene Expression
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Raav Is A Useful Vector For The Stable Expression Of Therapeutic Genes In The Myocardium And Is Used To Deliver Genes For Inducing Angiogenesis, Inhibiting Angiogenesis, Stimulating Cell Proliferation, Inhibiting Cell Proliferation And/Or Treating Or Ameliorating Other Cardiovascular Conditions.
  • Her2 Dna Vaccine As Adjunct Treatment For Cancers In Companion Animals
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Controlling Gene Expression Inhibition In Cells; Obtain Cells, Transform With Preferential Nucleotide Sequences, Recover Transform Cells, Monitor Gene Expression, Adjustment In Gene Expression, Indicate Gene Expression Inhibitor
  • Hbv Epitope Reactive Exogenous T Cell Receptor (Tcr) And Uses Thereof
  • Defective Recombinant Adenovirus Comprising A Nucleic Acid Sequence Coding For A Biologically Active Human Lipoprotein Lipase
  • Recombinant Protein Bodies As Immunogen-Specific Adjuvants
  • Covalent Coupled Of Nucleic Acids, Peptides Or Proteins To Active Material For Enhancing Transfection Efficiency; Potentiation
  • Polyclonal Immunoglobulin For Use In Diagnosis, Prevention And Treatment Of Infection, Cell Proliferative, Blood, Autoimmune And Nervous System Disorders
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Stress-Responsive Induction Of A Therapeutic Agent And Methods Of Use
  • Antiedema Agents, Adenovirus Genomes, Nucleotide Sequences And Transferring Adenoviral Genetic Vectors
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Methods For Producing Micrornas
  • Chimeric Polypeptides And Uses Thereof
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Methods For Enhanced Virus-Mediated Dna Transfer Using Molecules With Virus- And Cell-Binding Domains
  • Wnt-3 Polynucleotides
  • Methods And Means For Targeted Gene Delivery
  • Medical Equipment Comprising Nucleic Acid Codes For Wild-Type Human Kinase Interacting Stathmin (Hkis) Phosphoproteins, Used For Drug Delivery; Antiproliferative Agents
  • Use Of Marrow-Derived Glial Progenitor Cells As Gene Delivery Vehicles Into The Central Nervous System
  • Virology And Gene Therapy; Modified Fiber Knob Retains Its Ability To Trimerize And Retains Its Native Biosynthesis Profile
  • Compositions And Methods For The Therapy And Diagnosis Of Colon Cancer
  • Retrovirus Packaging Cell
  • Cancer Treatment With Endothelin Receptor Antagonists
  • E.G. (6,7-(Dimethoxyquinazolin-4-Yl)-(3-Ethynylphenyl)-Amine; Epidermal Growth Factor Receptor (Egf-R) Antagonist, Tyrosine Kinase Inhibitor; Hypersecretion Of Mucus In Lungs: Chronic Bronchitis, Acute Asthma, Cystic Fibrosis, Bronchiectasis, Chronic Obstructive Lung Disease
  • Refolding Transforming Growth Factor Beta Family Proteins
  • Destruction Of The Epithelium Of An Exocrine Gland In The Prophylactic And Therapeutic Treatment Of Cancer
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Method For Introducing A Molecule Into The Cytosol Of A Cell In Which The Cell Is Contacted With A Photosensitising Agent, The Cell Is Irradiated With Light Of A Wavelength Effective To Activate The Photosensitising Agent And, Substantially At The
  • Forming Densified Nucleic Acid Gene Material Without Biolistic Core Carrier For Transdermal Delivery Needleless Injection
  • Nonsystemically Administering An Exogenous Nucleic Acid Linked To A Promoter And Flanked By Native Parvoviral Inverted Terminal Repeats To Non-Neuronal Tissue Of Mammal; Gene Expression Continues Past 28 Days
  • Genomes, Gag, Pol And Envelope Proteins
  • Herpes Simplex Virus Vaccines
  • Osteoblast-Specific Transcription Factor (Osf2/Cbfa1); Polypeptides/Polynucleotides That Regulate Osteoblast Differentiation And Stimulate Bone Growth; Immunoassays; Detection Kits; Drug Screening
  • Alternate Site Gene Therapy
  • Recombinant Nucleic Acid Vector Comprising A Nucleotide Sequence Encoding A Syncytium-Inducing Polypeptide Expressible On A Eukaryotic Cell Surface
  • Bioactive Peptides And Peptide Derivatives Of Parathyroid Hormone (Pth) And Parathyroid Hormone-Related Peptide (Pthrp)
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Immunomodulatory Polynucleotides In Treatment Of An Infection By An Intracellular Pathogen
  • Circuit Arrangement For Injecting Nucleic Acids And Other Biologically Active Molecules Into The Nucleus Of Higher Eucaryotic Cells Using Electrical Current
  • Protein; Inducvtion Immunology Response Using Antibodies
  • Modified Polynucleotides Encoding Septin-4
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Strand Rna Viruses, And Process For The Production Of Such Viruses Encoding Additional Antigenically Active Proteins
  • Use Of A Vector Expressing Dna Polymerase Β As Medicine
  • Suppression Of Rejection Of Grafted Synthetic Or Allogenic Organ Or Grafted Tissue To Be Transplanted With Dna Encoding
  • Tc-83-Derived Alphavirus Vectors, Particles And Methods
  • Anti-Nucleolin Agent-Conjugated Nanoparticles As Radio-Sensitizers And Mri And/Or X-Ray Contrast Agents
  • Targeting Slow-Growing, Relatively Mutationally Spared Cancer Stem Line; Early Cancer Treatment And Reduce The Likelihood Of Clinical Relapse
  • Disintegrin And Metalloproteinase Containing Thrombospondin 1-Like Domains (Adamts); Adamts13 Protease And To Nucleic Acids Encoding Adamts13 Proteases; Von Willebrand Bactor Cleaving Protease Activity; Treating Acquired Thrombotic Thrombocytopenic Purpura; Anticoagulant Drug Development
  • Antisense Modulation Of Ptp1b Expression
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
  • Ultrasound Catheter
  • Hutc As Therapy For Alzheimer's Disease
  • Method Of Detection Of Nucleic Acids With A Specific Sequence Composition
  • Repair And Regeneration Of Ocular Tissue Using Postpartum-Derived Cells
  • Cell Lines
  • Ultra High Affinity Neutralizing Antibodies
  • High Potency Recombinant Antibodies And Method For Producing Them
  • Delivery Of A Neurotrophin To Targeted Defective, Diseased Or Damaged Cholinergic Neurons
  • Targeted Vectors For Cancer Immunotherapy
  • Rna Interference Mediating Small Rna Molecules
  • Replication-Defective Recombinant Virus Includes Promoter From Human Major Intrinsic Protein Or Human Crystallin And An Open Reading Frame Of Human Ras, Herpes Simplex Type I Thymidine Kinase, Or Non-Phosphorylatable Retinoblastoma
  • Materials And Methods For Delivery And Expression Of Heterologous Dna In Vertebrate Cells
  • Methods For Encapsulating Nucleic Acids In Lipid Bilayers
  • Virology And Gene Therapy; Modified Fiber Knob Retains Its Ability To Trimerize And Retains Its Native Biosynthesis Profile
  • Forming Densified Nucleic Acid Gene Material Without Biolistic Core Carrier For Transdermal Delivery Needleless Injection
  • Method Of Detection Of Nucleic Acids With A Specific Sequence Composition
  • Repair And Regeneration Of Ocular Tissue Using Postpartum-Derived Cells
  • Targeted Vectors For Cancer Immunotherapy
  • Rna Interference Mediating Small Rna Molecules
  • Delivery Of A Neurotrophin To Targeted Defective, Diseased Or Damaged Cholinergic Neurons
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Strand Rna Viruses, And Process For The Production Of Such Viruses Encoding Additional Antigenically Active Proteins
  • Cell Lines
  • Ultra High Affinity Neutralizing Antibodies
  • High Potency Recombinant Antibodies And Method For Producing Them
  • Correction Of Alpha-1-Antitrypsin Genetic Defects Using Spliceosome Mediated Rna Trans Splicing
  • Oxygen Sensing And Hypoxic Selection For Tumors
  • Dextrin Polymers In Combination With Sugars Provide Enhanced Delivery Of Nucleic Acids, Particularly Eucaryotic Expression Vectors, Demonstrate Enhanced Delivery Of Nucleic Acids To Cells In Vivo
  • Scleroprotein Of An Adeno-Associated Virus With Modified Chromatographic Properties, The Production Thereof And Use Of The Same
  • Universal Gm-Csf Expressing Bystander Human K562 Cell Line
  • Cationic Lipopolymer As Biocompatible Gene Delivery Agent
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Genomes, Gag, Pol And Envelope Proteins
  • Nonsystemically Administering An Exogenous Nucleic Acid Linked To A Promoter And Flanked By Native Parvoviral Inverted Terminal Repeats To Non-Neuronal Tissue Of Mammal; Gene Expression Continues Past 28 Days
  • Gene Expression With Covalently Modified Polynucleotides
  • Immunoglobulin Light Chain For Prevention And Treatment Of Alzheimers; Host Cells
  • Method To Detect Prostate Cancer In A Sample
  • Characterization Of Gene Function Using Double Stranded Rna Inhibition
  • Exposing Culture Of Cells Which Transiently Expresses Receptor Potential Protein To Compounds, Determining If Exposure Affects Gene Expression Of That Protein
  • Nucleotide Sequences Coding Preferential Polypeptide For Use In Treatment Of Sleep Disorder
  • Genes Displaying Enhanced Expression During Cellular Senescence And Terminal Cell Differentiation And Uses Thereof
  • Febp1 Protein Vector Host Cells And Method For Making Febp1 Protein
  • Binding Proteins That Bind To Human Fgfr1c, Human Β-Klotho And Both Human Fgfr1c And Human Β-Klotho
  • Histone Acetylase Inhibitor
  • Viral Expression Vectors Comprising A Ribosomal Promoter Sequence
  • Mammalian Two-Hybrid System For Screening For Modulators Of The Accumulation Of Metabolic Products
  • Administering Polypeptide; Prostate Gland Disease
  • Treatment Of Neurological Injury By Administration Of Human Umbilical Cord Tissue-Derived Cells
  • Pathotropic Targeted Gene Delivery System For Cancer And Other Disorders
  • Helper Virus-Free Herpesvirus Vector Packaging System
  • Antisense Modulation Of Ptp1b Expression
  • Fgf21 Mutants Multimers And Uses Thereof
  • Contain Alphavirus 5' And Alphavirus 3' Replication Recognition Sequences And A Nucleotide Sequence Encoding An Alphavirus Structural Protein; Alphavirus Replicon Particles Useful As Immunostimulants
  • Methods And Compositions For Genomic Modification
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Parathyroid Hormone Analogs And Uses Thereof
  • Anti-P53 Single-Chain Antibody Fragments And Their Uses
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Vascular Endothelial Growth Factor 2
  • Vectorization System Comprising Nanoparticles Of Homogenous Size Of At Least One Polymer And At Least One Positively Charged Polysaccharide And Method For The Preparation Thereof
  • Methods Of Increasing Lean Tissue Mass Using Ob Protein Compositions
  • Polypeptide
  • Antihemophilic Factor For Use In The Treatment Of Blood Disorders; Corrects Hemophilia In A Patient Deficient In Factor Viii Or Having Inhibitors To Factor Viii
  • Tetracycline-Regulated Gene Expression In Hsv-1 Vectors
  • Modified Polynucleotides For Treating Protein Deficiency
  • Use Of Such Proteins In Isolating Various Types Of Attenuated Viruses For The Development Of Vaccine And Pharmaceutical Formulations; Protocols Utilizing Interferon Antagonists, E.G., Ns1, To Enhance Gene Therapy Or Dna Vaccination Based On Their Ability To Increase Gene Expression
  • Preventing Airway Mucus Production By Administration Of Egf-R Antagonists
  • Human Antigen Binding Proteins That Bind Β-Klotho, Fgf Receptors And Complexes Thereof
  • Methods For Treating Obesity Using Fibroblast Growth Factor-Like Polypeptides
  • Thrombopoietic Compounds
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Retrovirus Packaging Cell
  • Cancer Treatment With Endothelin Receptor Antagonists
  • E.G. (6,7-(Dimethoxyquinazolin-4-Yl)-(3-Ethynylphenyl)-Amine; Epidermal Growth Factor Receptor (Egf-R) Antagonist, Tyrosine Kinase Inhibitor; Hypersecretion Of Mucus In Lungs: Chronic Bronchitis, Acute Asthma, Cystic Fibrosis, Bronchiectasis, Chronic Obstructive Lung Disease
  • Nucleic Acid-Lipopolymer Compositions
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Methods And Compositions For Promoting Survival And Proliferation Of Endothelial Cells And Stimulating Angiogenesis
  • Interleukin-4 (Il-4) Mutein Receptor Antagonist Operatively Linked To An Interleukin-9 (Il-9) Mutein Receptor Antagonist; Can Specifically Disrupt The Formation Of An Il-4 Receptor, An Il-9 Receptor, An Interleukin-13 (Il-13) Receptor; Useful In Treatment Of Asthma And Other Pulmonary Disorders
  • Recombinant P53 Adenovirus Compositions
  • Targeting Molecule Linked To An Imaging Agent
  • Noncovalent Complex Having Net Positive Charge At Ph 6.0-8.0, The Complex Comprising A Nucleic Acid, At Least One Cationic Lipid, And A Polycation, Where Polycation Is A Cationic Peptide Or A Polypeptide Comprising Polylysine, Polyornithine, Or Polyarginine; Gene Therapy
  • Implantable Drug Delivery Device And Use Thereof
  • Fk506-Based Regulation Of Biological Events
  • Enables The Efficient Integration Of Foreign Dna Into Host Cells; An Integrase Gene, A Segment Of Dna For Controlling The Expression Of The Integrase Gene, And An Integrase Recognition Region When Integrase Catalyzes The Integration Reaction
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Chimeric Vectors
  • Human Abc1 Promoter And Assays Based Thereon
  • Compositions And Methods For The Therapy And Diagnosis Of Colon Cancer
  • Administering To A Human, A Naked Dna Comprising A Dna Fragment Encoding A Polypeptide Consisting Essentially Of A Portion Of An Immunogenic Dust Mite Antigen; Fragment Is Amplified By A Primer Pair; Dermatophagoides; Antiallergens
  • Transducing Neuron With Gene; Muscular Disorders
  • Recombinant Adeno-Associated Virus (Raav) Vector Comprising A Heterologous Sequence And Heparin; For Gene Therapy
  • Hepatitis Therapeutics
  • Methods Of Treating Various Cancers Using Melanoma Differentiation Associated Protein-7
  • Prevention And Treatment Of Amyloidogenic Disease
  • Targeted Chromosomal Genomic Alterations With Modified Single Stranded Oligonucleotides
  • Ultrasonic Catheter Power Control
  • Using Vector Comprising Early Gene Modifications As Genetic Transfer Element In Gene Therapy; Gnentic Vaccines
  • For Regenerating Tissues; Antiaging Agents; Medical Diagnosis; Monitoring Chemotherapy
  • Kiaa0175 Inhibitor Is Selected From The Group Consisting Of An Anti-Sense Molecule, A Ribozyme, An Antibody, An Antibody Fragment, A Protein, A Polypeptide And A Small Molecule.
  • Treating A Vascular Disease, Administering A Double Stranded Nucleic Acid Specific Binding To A Transcription Factor; Antiproliferative Agents
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • G-Protein Coupled Receptors
  • Genetic Demonstration Of Requirement For Nkx6.1, Nkx2.2 And Nkx6.2 In Ventral Neuron Generation
  • Genes Associated With Diseases Of The Kidney
  • Il-17 Receptor A Antigen Binding Proteins
  • Fgf21 Mutants And Uses Thereof
  • Methods Of Ameliorating Symptoms Of Herpes Infection Using Immunomodulatory Polynucleotide Sequences
  • For Extending Clinical Utility Of Interferon (Ifn) Alpha In Treatment Of A Variety Of Viral And Proliferative Disorders; Increase Efficacy Of Ifn- Alpha And Reduce Ifn- Alpha Treatment-Related Side Effects
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Given Nucleotide Sequence; Use In Diagnosis And Treatment Of Rheumatoid And Osteo-Arthritis
  • Immunostimulatory Polynucleotide/Immunomodulatory Molecule Conjugates
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Gene Therapy For Cancer
  • Methods And Compositions For The Inhibition Of Trpv4
  • Influenza Virus Replication For Vaccine Development
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Treating Neurological Disorders
  • Ligand Targeted Nanocapsules For The Delivery Of Rnai And Other Agents
  • Adenoviral Vector Encoding Human Atonal Homolog-1 (Hath1)
  • Delivery Of Polynucleotides By Secretory Gland Expression
  • Methods And Materials Used To Isolate And Detect A High Bone Mass Gene And A Corresponding And Mutants Thereof; Treating, Diagnosing And Preventing Osteoporosis
  • Pharmaceutical Compositions With Resistance To Soluble Cea
  • Vectors And Methods For Immunization Or Therapeutic Protocols
  • Introducing Foreign Dna Into Cell; Contacting Before, During, Or After With Biocompatible Expression Enhancing Agent Which Is Not Butyrate Or Butyric Acid; Maintaining In Non-Selective Medium; After 5 Days, Detecting Foreign Protein
  • Production And Use Of Rat Spermatogonial Stem Cell Lines
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Polypeptide Derivatives Of Parathyroid Hormone (Pth)
  • Metabolically Activated Recombinant Viral Vectors And Methods For Their Preparation And Use
  • Serotype Of Adenovirus And Uses Thereof
  • Genetic Suppression And Replacement
  • High Bone Mass Gene Of 11q13.3
  • Nucleic Acid Compositions And Their Use Against The Hepatitic C Virus
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Treatment Of Stroke And Other Acute Neural Degenerative Disorders Via Intranasal Administration Of Umbilical Cord-Derived Cells
  • Feline Granulocyte Macrophage Colony Stimulating Factor Proteins
  • Mammalian Iap Gene Family, Primers, Probes And Detection Methods
  • Mutz-3 Dendritic Cells
  • Expression Of Hiv Polypeptides And Production Of Virus-Like Particles
  • System For Optical Stimulation Of Target Cells
  • Using Channel Protein To Identify Inhibitors Of Bitter And/Or Sweet Taste Preception
  • Antitumor Agents; Gene Therapy
  • Drug Comprising As The Active Ingredient Proliferative Vector Containing Survivin Promoter
  • Rna Interference Mediating Small Rna Molecules
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulation Of Angiogenesis And Anticancer Therapy
  • Use Of Vegf And Homologues To Treat Neuron Disorders
  • For Gene Therapy; Enhanced Targeting Potential; Chimeric Molecule Containing Heterologous Trimerization Motif And Receptor-Binding Ligand
  • Circovirus Sequences Associated With Piglet Weight Loss Disease (Pwd)
  • Using Dispersed Regulatory Nucleotide Sequences To Regulate Transcription In Animal Cells, Tissues And/Or Organs; Gene Expression Inhibition
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • P53 Vaccines For The Treatment Of Cancers
  • Multimeric Forms Of Members Of The Steroid/Thyroid Superfamily Of Receptors With The Ultraspiracle Receptor
  • Polypeptide Variants Of Sleeping Beauty Transposase
  • Compositions And Methods For Regulating Angiogenesis
  • Materials And Methods For Reducing Inflammation By Inhibition Of The Atrial Natriuretic Peptide Receptor
  • Polymer Conjugated Glycosylated Neublastin
  • Calpain Inhibitors And Their Applications
  • Recombinant Animal Viral Nucleic Acids
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Cloning Of Reporter Genes And Cdna Encoding For Therapeutic Proteins For The Treatment Of Hepatic, Pulmonary, Renal, Heart, Pancreas Fibrosis, Keloids And Hypertrophic Scars, In Mammals, Including Human Beings
  • Have Specificity For Antigens Displayed By Microorganisms, Especially Viruses, As Well As Antigenic Sites Present On Cancer Cells And On Various Types Of Toxins, And Products Of Toxins
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • For Extending Clinical Utility Of Interferon (Ifn) Alpha In Treatment Of A Variety Of Viral And Proliferative Disorders; Increase Efficacy Of Ifn- Alpha And Reduce Ifn- Alpha Treatment-Related Side Effects
  • Postpartum Cells Derived From Placental Tissue, And Methods Of Making And Using The Same
  • Methods And Compositions For Using Sax2
  • Methods And Means For Obtaining Modified Phenotypes
  • Introducing A Molecule Capable Of Specifically Recognizing A Prostate Tumor Inducing Gene Into Cell Under Conditions Permitting Inhibition Of Expression Of Gene So As To Reverse Cancerous Phenotype Of The Cell
  • For Indentifying Receptor-Independent Activators Of Pheromone Response Pathway; Devised In Yeast Saccharomyces Cerevisiae; Activator Of G-Protein Signaling (Ags)
  • Use Of The P-Ten Suppressor Gene In Diagnosis And Treatment Of Cancer
  • Treatment Of Stroke And Other Acute Neuraldegenerative Disorders Using Postpartum Derived Cells
  • Functional Dna Clone For Hepatitis C Virus (Hcv) And Uses Thereof
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulation Of Angiogenesis And Anticancer Therapy
  • Modulating Apoptosis Or Proliferation Of A Cancer Cell, Comprising Regulating Expression Of Shinc-2
  • Post-Transcriptional Gene Silencing Using Expressed Double Stranded Rna
  • Alphavirus Replicon Vector Systems
  • Method Of Treating Lupus Nephritis
  • Composition And Method For Inhibiting Tumor Cell Growth
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Method And Apparatus For Device Controlled Gene Expression
  • Tetracycline-Regulated Gene Expression In Hsv-1 Vectors
  • Gene Delivery Vectors Provided With A Tissue Tropism For Smooth Muscle Cells, And/Or Endothelial Cells
  • Hybrid Particle Containing Capsids And Genomes; Genetic Engineering
  • Method To Inhibit Cell Growth Using Oligonucleotides
  • Cell Culture Methods For Producing Recombinant Proteins In The Presence Of Reduced Levels Of One Or More Contaminants
  • Use Of Vegf-C To Prevent Restenosis
  • Method For Detecting Loss Of Wild-Type P53
  • For Diagnosing Degenerative Disorders Characterized In Inappropriate Cell Proliferation Or Inappropriate Cell Death; Formonitoring The Progress Of Such Degenerative Disorders
  • For Gene Therapy; Improved Retrovirus Vector Packaging
  • Intravascular Delivery Of Nucleic Acid
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Identifying Viricidal Agents Which Prevent Cytomegalo Viral Infection And Distribution; Gene Expression Inhibition
  • Cell Populations, Methods Of Transdifferentiation And Methods Of Use Thereof
  • Administering Pharmaceutical Composition Comprising Adenoviral Vector Comprising Promoter Functional In Eukaryotic Cells And Nucleic Acid Encoding P16 And Buffer, Solvent Or Diluent To Mammal To Inhibit Tumor Growth
  • Adenovirus E4 Proteins For Inducing Cell Death
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Postpartum Cells Derived From Umbilical Cord Tissue, And Methods Of Making And Using The Same
  • A Pseudotyped Feline Immunodeficiency Virus Virion; Transfection; Expression Vectors Packaged In Packaging Cells To Generate High Titer Recombinant Virus Stocks; Gene Therapy
  • Fgf Mutants With Reduced Proteolysis And Aggregation
  • Nucleotide Sequences Coding Nvelope Protein For Use In The Prevention Of Viral Diseases
  • Usedf In Imaging Metastasized Tumors In Vivo; For Vaccines; Genetic Engineering; Kits
  • Prostate-Specific Antigen
  • Liver Regeneration Using Pancreas Cells
  • Variants Of Pigment Epithelium Derived Factor And Uses Thereof
  • Hybrid Amyloid-Beta Antibodies
  • Human Umbilical Cord Tissue Cells For Inhibiting Adverse Immune Response In Histocompatibility-Mismatched Transplantation
  • Compounds And Methods For Therapy And Diagnosis Of Lung Cancer
  • Gene Overexpressed In Cancer
  • Compositions For Targeted Gene Delivery
  • Ob Fusion Protein Compositions And Methods
  • Influenza Virus Replication By Inhibiting Microrna Lec7c Binding To Influenza Viral Crna And Mrna
  • Double-Stranded Oligonucleotides
  • Specific Inhibition Of Expression Of Target Gene In Mammals Using Short Double Stranded Rna; Dsrna Less Than 49 Nucleotides In Length, Has Nucleotide Sequence Complementary To Part Of Target Gene; Treating Cancer, Alzheimer's Disease
  • Methods For Regulating The Specific Lineages Of Cells Produced In A Human Hematopoietic Cell Culture, Methods For Assaying The Effect Of Substances On Lineage-Specific Cell Production, And Cell Compositions Produced By These Cultures
  • Recombinant, Thymidylate Synthase Defective, Lactococcus Comprising Heterologous Interleukin-10 Gene For Use As Gene Therapeutic Tool In Treatment Of Inflammatory Bowel Disease
  • Colloidal Metal Compositions And Methods
  • Decellularized Bone Marrow Extracellular Matrix
  • Microorganisms For Therapy
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Nucleotide Sequence (Loxp Site) Where In The Presence Of Recombinase Cre, Recombination With A Wild-Type Loxp Site Can Not Occur, And Recombination Between Two Mutant Loxp Sites Having The Identical Sequence Occur; Gene Transfer
  • Colloidal Metal Compositions And Methods
  • Inhibition Of Pex In The Treatment Of Metabolic Bone Diseases
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Increasing Fficiency Of Transduction Of Hematopoietic Cells; Infecting Cells In Presence Of Fibronectin; Stem Cells; Gene Therapy; Efficient Retroviral Infection Of Mammalian Cells
  • Artificial Chromosomes, Uses Thereof And Methods For Preparing Artificial Chromosomes
  • Porcine Adenovirus Type 3 Genome
  • Gene Transfer Into Airway Epithelial Stem Cell By Using Lentiviral Vector Pseudotyped With Rna Virus Or Dna Virus Spike Protein
  • Cell Permeable Peptides For Inhibition Of Inflammatory Reactions And Methods Of Use
  • Chimeric Adenoviruses
  • Rna Interference Mediating Small Rna Molecules
  • Methods And Compositions For Enhancing Intranasal Delivery Of Therapeutic Agents
  • Expression Vectors Having A Reduced Content Of Viral Genes, Are Safer Because Of Expressing More Nonviral Nucleotide And Much Less Immunogenic Or Toxic Proteins; Contain Less Than 400 Bp Of The Nucleotide Sequwence Which Codes For Gag
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Method Of Treating Lupus Nephritis
  • Composition And Method For Inhibiting Tumor Cell Growth
  • Modulating Apoptosis Or Proliferation Of A Cancer Cell, Comprising Regulating Expression Of Shinc-2
  • Alphavirus Replicon Vector Systems
  • Compositions And Methods Of Altering Cholesterol Levels
  • Use Of Vegf-C To Prevent Restenosis
  • For Gene Therapy; Improved Retrovirus Vector Packaging
  • Variants Of Pigment Epithelium Derived Factor And Uses Thereof
  • For Diagnosing Degenerative Disorders Characterized In Inappropriate Cell Proliferation Or Inappropriate Cell Death; Formonitoring The Progress Of Such Degenerative Disorders
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Intravascular Delivery Of Nucleic Acid
  • Method For Detecting Loss Of Wild-Type P53
  • Identifying Viricidal Agents Which Prevent Cytomegalo Viral Infection And Distribution; Gene Expression Inhibition
  • Cell Populations, Methods Of Transdifferentiation And Methods Of Use Thereof
  • Administering Pharmaceutical Composition Comprising Adenoviral Vector Comprising Promoter Functional In Eukaryotic Cells And Nucleic Acid Encoding P16 And Buffer, Solvent Or Diluent To Mammal To Inhibit Tumor Growth
  • Ligand Targeted Nanocapsules For The Delivery Of Rnai And Other Agents
  • Adenoviral Vector Encoding Human Atonal Homolog-1 (Hath1)
  • Delivery Of Polynucleotides By Secretory Gland Expression
  • Hybrid Particle Containing Capsids And Genomes; Genetic Engineering
  • Method To Inhibit Cell Growth Using Oligonucleotides
  • Cell Culture Methods For Producing Recombinant Proteins In The Presence Of Reduced Levels Of One Or More Contaminants
  • Usedf In Imaging Metastasized Tumors In Vivo; For Vaccines; Genetic Engineering; Kits
  • Prostate-Specific Antigen
  • Liver Regeneration Using Pancreas Cells
  • Post-Transcriptional Gene Silencing Using Expressed Double Stranded Rna
  • Mink-Related Genes, Formation Of Potassium Channels And Association With Cardiac Arrhythmia
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulation Of Angiogenesis And Anticancer Therapy
  • Anti-Cd98 Antibody Processes
  • Methods And Materials Used To Isolate And Detect A High Bone Mass Gene And A Corresponding And Mutants Thereof; Treating, Diagnosing And Preventing Osteoporosis
  • Pharmaceutical Compositions With Resistance To Soluble Cea
  • Methods And Compositions For Using Sax2
  • Homodimeric Protein Constructs
  • Methods And Means For Obtaining Modified Phenotypes
  • Antisense Modulation Of Ptp1b Expression
  • Expression Cassette Generated From These Sequences; Generating An Immune Response In A Subject
  • Nucleic Acids Encoding Sb10 Variants
  • Ob Fusion Protein Compositions And Methods
  • Adenovirus E4 Proteins For Inducing Cell Death
  • Lipoxygenase Proteins And Polynucleotides Encoding The Same
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Nucleotide Sequences, Proteins, Drugs And Diagnostic Agents Of Use In Treating Cancer
  • Gene Delivery Vectors Provided With A Tissue Tropism For Smooth Muscle Cells, And/Or Endothelial Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Oligonucleotide-Directed Repair Or Alteration Of Genetic Information
  • Vectors And Methods To Treat Ischemia
  • Cross-Species-Specific Psmaxcd3 Bispecific Single Chain Antibody
  • Use Of Meganucleases For Inducing Homologous Recombination Ex Vivo And In Toto In Vertebrate Somatic Tissues And Application Thereof
  • Materials And Methods For Reducing Inflammation By Inhibition Of The Atrial Natriuretic Peptide Receptor
  • Methods Of Treating Retinitis Pigmentosa Using Nucleic Acids Encoding Rdcvf1 Or Rdcvf2
  • Compositions And Methods For Treating Intracellular Diseases
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Nucleic Acid Compositions And Their Use Against The Hepatitic C Virus
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Method And Apparatus For Device Controlled Gene Expression
  • Tetracycline-Regulated Gene Expression In Hsv-1 Vectors
  • Compositions And Methods For Treating Diseases
  • Chimeric Newcastle Disease Viruses And Uses Thereof
  • Inhibition Of Smooth Muscle Cell Migration By Heme Oxygenase I
  • A Hybridome Called 5c5 (Cncm No I-2184) And The Monoclonal Antibody 5c5 Which It Produces; For Diagnosing Human Renal Cell Carcinoma; Diagnosis Kit
  • Remedies For Hepatitis
  • Therapeutic Dna Vaccination
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Telomelysin/Gfp-Expressing Recombinant Virus
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Composition And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis And Abnormal Cell Proliferation
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Modified Rna With Decreased Immunostimulatory Properties
  • For Gene Therapy; Gene Expression Inhibition; Genetic Engineering; Drugs; Simian Virus (Sv40)
  • Attenuated Viruses Comprising Modified Ns1 Genes, Having An Impaired Ability To Antagonize The Cellular Interferon Response; Decreased In Vivo Replication, Virulence And Increased Attenuation; Live Cancer Vaccines
  • Polynucleotides Encoding Il-17 Receptor A Antigen Binding Proteins
  • Polynucleotides Encoding Il-17 Receptor A Antigen Binding Proteins
  • Hepatocyte Growth Factor Gene As Drug; Topical Applying ; Side Effect Reduction; Cardiovascular Disorders
  • Imaging, Diagnosis And Treatment Of Disease
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Transfection Efficiency
  • Therapeutic Dna Vaccination
  • A Hybridome Called 5c5 (Cncm No I-2184) And The Monoclonal Antibody 5c5 Which It Produces; For Diagnosing Human Renal Cell Carcinoma; Diagnosis Kit
  • Modified Vaccinia Virus Strains For Use In Diagnostic And Therapeutic Methods
  • Ehrlichia Canis Genes And Vaccines
  • Immunizing Fish Against Bacterial And Viral Infection By Immersing The Fish In A Solution Comprised Of An Effective Amount Of Dead Or Attenuated, Whole-Celled Recombinant Bacteria, The Recombinant Bacteria Having A Eukaryotic Expression Vector (Plasmid) Incorporated Therein Having Dna Of Interest
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Vero Cells
  • Uteroglobin Gene Therapy For Epithelial Cell Cancer
  • Targeted Integration And Expression Of Exogenous Nucleic Acid Sequences
  • Imaging, Diagnosis And Treatment Of Disease
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Tc-83-Derived Alphavirus Vectors, Particles And Methods
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Nucleic Acids Encoding Fluorescent Proteins And Methods Of Using The Same
  • Telomelysin/Gfp-Expressing Recombinant Virus
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Composition And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis And Abnormal Cell Proliferation
  • For Gene Therapy; Gene Expression Inhibition; Genetic Engineering; Drugs; Simian Virus (Sv40)
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Modified Rna With Decreased Immunostimulatory Properties
  • Hepatocyte Growth Factor Gene As Drug; Topical Applying ; Side Effect Reduction; Cardiovascular Disorders
  • Methods Of Cancer Diagnosis And Therapy Targeted Against A Cancer Stem Line
  • Anti-Nucleolin Agent-Conjugated Nanoparticles
  • Methods And Compositions For Detection Of Microorganisms And Cells And Treatment Of Diseases And Disorders
  • A Transgenic Mouse; The Enzyme For Treating Inflammation, Smooth Muscle Contraction; Animal Models
  • Gene Delivery Vehicle Expressing The Aptosis-Inducing Proteins Vp2 And/Or Apoptin
  • Obtaining Long Lasting Immunity Via Delivery To Antigen Presenting Cell A Complex Comprising Nucleic Acid Encoding First Epitope And Peptide Containing Second Epitope
  • Formulation And Delivery Of Plga Microspheres
  • Inositol 1,4,5-Triphosphate (Ip3); Use In Gene Therapy Of Diseases Associated With Calcium Production In The Nervous System, Blood Vascular System, Respiratory System, Digestive System, Lymphatic System, Urogenital System
  • Administering A Target Cell-Specific Adenovirus Vector, Comprising An Adenoviral Gene Essential For Replication Under Transcriptional Control Of A Target Cell-Specific Transcriptional Regulatory Element And An Anticancer Agent
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Means And Methods For The Specific Modulation Of Target Genes In The Cns And The Eye And Methods For Their Identification
  • Adenovirus Vectors Containing Cell Status-Specific Response Elements And Methods Of Use Thereof
  • Remedies For Hepatitis
  • Clonal Strains Of Attenuated Vaccinia Viruses And Methods Of Use Thereof
  • Antisense Modulation Of Ptp1b Expression
  • Epidermal Growth Factor
  • In Vitro Expansion Of Postpartum-Derived Cells In Roller Bottles
  • Administering To Respiratory Tract; Phase Inversion Microencapsulation; Noninvasive
  • Humanized Fcγr Mice
  • Altering Human Immune Response To Adenoviral Vector Via Modification Of Capsid Proteins; Improved Exogenous Gene Expression
  • Treating Diabetes Or Obesity Using Isolated Polypeptide Is Covalently Modified With A Water-Soluble Polymer
  • Introducing At Least One Modification Into A Structural Protein Of Adeno-Associated Virus (Aav) The Structural Protein Being Selected From The Group Consisting Of Aav Vp1, Vp2, And Vp3, Wherein The Modification Brings About A Reduction In The Antigenicity Of The Virus Relative To Wild-Type Aav
  • Adenovirus Comprising Dna With A Origin Of Replication Of Epstein-Barr Virus, Promoter, Nucleotide Sequence Encoding A Protein And Internal Ribosome Entry Site Sequence Of An Encephalomyocarditis Virus; Site-Specific Recombination
  • Mink-Related Genes, Formation Of Potassium Channels And Association With Cardiac Arrhythmia
  • Antisense Modulation Of Ptp1b Expression
  • Antisense Modulation Of Ptp1b Expression
  • High Titer Recombinant Influenza Viruses For Vaccines
  • Vector
  • Method Of Intracellular Binding Of Target Molecules
  • Antitumoral Composition Based On Immunogenic Polypeptide With Modified Cell Location
  • Transducing Neuron With Gene; Alzheimer's Disease, Parkinson's Disease, Amyotropic Lateral Sclerosis
  • Cell-Mediated Targeting Of Toxins To Pathogenic Cells
  • Fgf-21 Mutants Comprising Polyethylene Glycol And Uses Thereof
  • Branched Dendrimeric Structures
  • Compositions And Methods For Therapeutic Use
  • High-Affinity Choline Transporter
  • Ex Vivo Gene Therapy For Hiv; Formulation Of Cd34+ Hematopoietic Cells Transduced With A Viral Construct Which Expresses An Anti-Hiv Agent Such As A Ribozyme
  • Delivering Viral Vectors To The Cns Are Provided.
  • Method Of Making A Genetically Modified Mammalian Cell
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Treatment Of Immune Disease By Mucosal Delivery Of Antigens Using Genetically Modified Lactococcus
  • Use Of Stem Cells To Generate Inner Ear Cells
  • Methods For Preventing Formation Of Inhibitory Antibodies In The Setting Of Gene Therapy
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Gene Therapy
  • Sphingolipid-Containing Cationic Liposomes For Topical Delivery Of Bioactive Material
  • Structural Protein Of Adeno-Associated Virus With Modified Antigenicity, Its Production And Its Use
  • Biomarkers And Combination Therapies Using Oncolytic Virus And Immunomodulation
  • Herpes Simplex Virus Amplicon Vector Targeting System And Method Of Using Same
  • Newcastle Disease Viruses And Uses Thereof
  • Antibodies Against The Rgm A Protein And Uses Thereof
  • Antibodies To Fibroblast Growth Factor-Like Polypeptides
  • Recombinant Replication-Defective Adenovirus Serotypes 11, 25, 34, 35, 48 And 49 As Gene Delivery Vehicles For Gene Therapy; Reduced Drug Resistance, Increased Effectiveness Of Vaccination; Nucleotide Sequence Encoding A Functional E4-Orf6 (Early Region 4 Open Reading Frame 6) Protein
  • Dna Viral Vector Comprising Nucleotide Seuences Coding Modified Capsid Protein For Use In Enhancement Of Heterologous Gene Transfer; Improved Exogenous Gene Expression
  • Administering An Adenovirus Expression Vector, Expressing A Protein On Cancer Cells For Treating Ovarian Cancer, Cervical Cancer, Stomach Cancer And Lung Cancer
  • Dopaminergic Neurons Differentiated From Embryonic Cells For Treating Neurodegenerative Diseases
  • Methods For Modulating Skeletal Remodeling And Patterning By Modulating Shn2 Activity, Shn3 Activity, Or Shn2 And Shn3 Activity In Combination
  • Nucleic Acids, Vectors And Transformed Cells For Making And Using High Affinity Ip-3 Binding Polypeptides
  • Influenza Virus Replication By Inhibiting Microrna Lec7c Binding To Influenza Viral Crna And Mrna
  • Porcine Adenovirus Type 3 Genome
  • Gene Transfer Into Airway Epithelial Stem Cell By Using Lentiviral Vector Pseudotyped With Rna Virus Or Dna Virus Spike Protein
  • Methods And Compositions For Enhancing Intranasal Delivery Of Therapeutic Agents
  • Expression Vectors Having A Reduced Content Of Viral Genes, Are Safer Because Of Expressing More Nonviral Nucleotide And Much Less Immunogenic Or Toxic Proteins; Contain Less Than 400 Bp Of The Nucleotide Sequwence Which Codes For Gag
  • Infant Gene Therapy
  • Methods And Compositions For Treating Metastatic Cancer
  • Attenuated Negative Strand Viruses With Altered Interferon Antagonist Activity For Use As Vaccines And Pharmaceuticals
  • Treatment Of Melanoma Using Hsv Mutant
  • Targeted Gene Modification By Parvoviral Vectors
  • In Vivo Production Of Proteins
  • Novel Inducible Animal Models Of Stress Behavior
  • Expression Of Fusion Proteins
  • Fgf21 Mutant Fusion Polypeptides And Uses Thereof
  • Anticancer Agents
  • Recombinant Adenovirus Helper-Dependent Vector With Adenovirus Inverted Terminal Repeat Sequences, At Least One Recombination Site, And Adenovirus Packaging Sequence, And Exogenous Dna To Be Expressed; Simple And Efficient Production
  • Rna Interference Mediating Small Rna Molecules
  • Methods For Introducing Genes Into Mammalian Subjects
  • Methods For Transfecting T Cells
  • Methods And Compositions For Treating Inflammatory Conditions
  • Method And Compounds For Controlling Capacitative Calcium Ion Entry Into Mammalian Cells
  • Nucleotide And Amino Acid Sequences Relating To Respiratory Diseases And Obesity
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Adeno-Associated Virus Capable Of Expressing Factor Ix Protein And Cells Comprising The Same
  • Internalisation Of Virus Into Cells
  • Gene Delivery System And Methods Of Use
  • Modalities For The Treatment Of Degenerative Diseases Of The Retina
  • Selective Induction Of Apoptosis To Treat Ocular Disease By Expression Of Pedf
  • Rna Interference Mediating Small Rna Molecules
  • Cell Lines
  • Control Of Gene Expression In Eukaryotic Cells
  • Supplying Nucleic Acids To Cells Being Grafted
  • Enhancer From Immunoglobulin; Polyadenylation Site; Gene Therapy
  • Defective Platelet Activation In Gαq Deficient Mice
  • Plasmid Comprising Ribosmal Protein Promoter Sequences For Use As Tool In Controlling And Enhancing Genic Expression In Transgenic Cells
  • Methods Of Gene Therapy Using Herpes Viral Vectors Expressing Gm-Csf
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Control Of Gene Expression
  • Use Of A Polypeptide As Cell Receptor For Adenoviruses
  • Mixture Of Gene Of Interest And Estradiol; For Efficient Targeted Non-Viral Gene Therapy Of Cytotoxic Genes, Prodrug Activators, Antimetastasis Agents, And Immune Surveillance Genes; For Anticarcinogenic/Antitumor Agents
  • Gene Transfer Into Airway Epithelial Stem Cell By Using Lentiviral Vector Pseudotyped With Rna Virus Or Dna Virus Spike Protein
  • Using A Nucleic Acid Capable Of Expressing Beta-Interferon; Treating Demyelinating Disease Such As Multiple Sclerosis
  • Murine Monoclonal Anti-Idiotype Antibody 11d10 And Methods Of Use Thereof
  • Precise Homologous Recombination-Mediated Gene Repair Via Use Of Chimeric Restriction Endonucleases
  • Use Of Hyaluronan In Gene Therapy
  • Transgene Expression System For Increased Persistence
  • Microorganisms For Therapy
  • Promoterless Cassettes For Expression Of Alpha Virus Structural Proteins
  • Isolated Monoclonal Anti-Repulsive Guidance Molecule A Antibodies And Uses Thereof
  • Vector Systems And Kits Using A Serotype Specific Strategy For Making Adenoviral Vector Preparations Substantially Free Of Replication Competent "Helper" Virus; For Use In Gene Transfer And Gene Therapy
  • Genes Involved In A Variety Of Cellular Processes, Including Retinal Degeneration, Cancer, Memory And Learning, And Identification Of The Function Of A Variety Of Genes And Gene Fragments Of Unknown Function
  • Therapy For Nervous System Degradation
  • For An Improved In Vitro And In Vivo Transformation Of Particular Cells, For Example For Somatic Gene Therapy; Diagnosis, Increased Infectivity For Cells Of Low Susceptibility, Such As Haematopoietic Cells
  • Lipoproteins As Nucleic Acid Vectors
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Manganese Superoxide Dismutase Exon 3-Deleted Isoforms And Nucleic Acid Molecules Encoding The Isoforms
  • Novel Nucleic Acid Molecules; Immunospecifically Binding Respiratory Syncytial Virus (Rsv) Antigens; Long Half Life; Reduced Dosage And Side Effects
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Treatments For Neurological Disorders
  • Methods For Transfecting T Cells
  • Recombinant Adenovirus Helper-Dependent Vector With Adenovirus Inverted Terminal Repeat Sequences, At Least One Recombination Site, And Adenovirus Packaging Sequence, And Exogenous Dna To Be Expressed; Simple And Efficient Production
  • Methods For Introducing Genes Into Mammalian Subjects
  • Targeted Gene Modification By Parvoviral Vectors
  • Anticancer Agents
  • In Vivo Production Of Proteins
  • Vaccinia Virus For Diagnosis And Therapy Of Tumors
  • Rna Interference Mediating Small Rna Molecules
  • Derived From The Murine Leukemia Virus, Comprises Elongation Factor-Alpha; For Gene Therapy
  • Toso Proteins And Related Molecules Which Have An Inhibitory Effect On Tnf Mediated Apoptosis
  • Glutamic Acid Decarboxylase (Gad) Based Delivery System
  • Pharmaceutical Composition Containing A Stabilised Mrna Optimised For Translation In Its Coding Regions
  • Administration To The Prefrontal Cortex Of Therapeutic Cells Which Produce Dopamine Or Dopamine Precursors Adhered To A Support Matrix
  • Gene Expression; Probes, Primers, Antibodies
  • Neublastin Variants
  • Natriuretic Peptide Receptor As A Biomarker For Diagnosis And Prognosis Of Cancer
  • Refolding Transforming Growth Factor Beta Family Proteins
  • Synthetic Genes And Genetic Constructs
  • Screening Methods Using G-Protein Coupled Receptors And Related Compositions
  • P101 Polypeptides
  • Fibroblast Growth Factor-Like Polypeptides
  • Insertion Target Ligands Into Proteins; Detection Fluorescent Signals; Determination, Calibration; Gene Therapy; Antitumor Agents
  • Methods For The Modulation Of Neovascularization And/Or The Growth Of Collateral Arteries And/Or Other Arteries From Preexisting Arteriolar Connections
  • Entomopoxvirus-Vertebrate Gene Delivery Vector And Method
  • Phosphoinositide (4,5) Bisphosphate As A Diagnostic Tool And Target For Cancer Treatment
  • Detection Of Prefrenial Nucleotide Sequences In Cells; Obain Cells, Transfor, Express Reporter Molecules, Presence Of Reporte Molecule Indicates Presence Of Preferntal Nucleotide Sequences
  • Induction Of Immune Response To Antigens Expressed By Recombinant Adeno-Associated Virus
  • Materials And Methods For Producing Improved Lentiviral Vector Particles
  • Human Embryonic Kidney Cells And Amniocytes; Capable Of Complementing Recombinanat Adenovirus
  • Administering, In Vivo, At Or Around The Site Of The Solid Tumor, A Nucleic Acid Which Encodes An Ip-10 Polypeptide, For Inhibiting A Solid Tumor In A Mammal
  • Dna Libraries; Genetic Engineered Nucleic Acids
  • Dna Construct Of An Activator Sequence, A Cell Cycle-Controlled Promoter, And Dna Which Codes For An Active Substance; Gene Therapy
  • Vectors For Gene Delivery
  • Compositions And Methods For Non-Targeted Activation Of Endogenous Genes
  • Polynucleotide Or Complement Comprising Nucleic Acid Sequence Flanked By First And Second Inverted Repeats
  • Methods For Enhanced Retroviral-Mediated Gene Transfer
  • Osteoactivin Protein And Nucleic Acids Encoding The Same, Compositions And Methods Of Stimulating Bone Differentiation
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Fot Treatment Of Disorders Of Bone Cartilage Or Lung Defect (Such As Osteoporosis And Cycstic Fibrosis) Via Transfection Comprising Herpes Thymidine Kinase Gene
  • A Genetic Construct Containing A Glucose Inducible Regulatory Element With A Pair Of Cacgtg Nucleotide Sequences And Confer Human Proinsulin Expression In Host Hepatocyte Cells; Therapy For Diabetes
  • Attenuated Influenza Ns1 Variants
  • Compositions And Methods For Treating Diseases
  • Comprise Monoclonal/Polyclonal Antibodies Against Cell Death Protein For Use In Preventing And Treating Degenerative Disorders Characterized By Inappropriate Cell Death/Proliferation; Antiproliferative/Antiapoptosis
  • Gene Delivery System
  • Expression Vector; For Use As Tool In Genetic Engineering And Gene Therapy
  • Diffusion Of Gases, Nutrients Into Micro-Organs; Culture; Cell Proliferation
  • Porcine Adenovirus E1 And E4 Regions
  • Providing A Population Of Pluripotent Hematopoetic Cells, Expanding Population Of Stem Cells To Yield Expanded Stem Cells, Inducing A Majority Of Cells In The Population Of Expanded Cells To Become Quiescent, Using Quiescent Cells
  • Using Adenoviral Transformation/Transfection To Transfer Cyclin And Cyclin Dependent Kinase Genes Into Nucleus Of Differentiated Cells; Regenerative Medicine And Tissue Engineering
  • Methods And Compositions For Promoting Survival And Proliferation Of Endothelial Cells And Stimulating Angiogenesis
  • Neurotrophic Factors And Methods Of Use Thereof
  • Production System For Producing Lentivirus-Based, Replication Defective Vector Particles For Gene Therapy
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • Anti-Cd98 Antibody Processes
  • Methods And Means For Obtaining Modified Phenotypes
  • Preventing Airway Mucus Production By Administration Of Egf-R Antagonists
  • Secreted Proteins
  • Methods Of Treating Retinal Nerve Fiber Layer Degeneration With Monoclonal Antibodies Against A Retinal Guidance Molecule (Rgm) Protein
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • A Nucleotide Sequence Capable Of Encoding An Antibody In Vivo
  • Method For Treating Cancer, Visualizing Cell Structures, And Isolating Organelles Using Organelle Crystallizing Agents
  • Trp8, A Transient Receptor Potential Channel Expressed In Taste Receptor Cells
  • Alphavirus Cdna Vectors
  • Carcinoma-Related Genes And Polypeptides And Methods Of Use Thereof
  • Adenoviral Vector Encoding Human Atonal Homolog-1 (Hath1)
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Methods And Compositions For The Treatment Of Lysosomal Storage Diseases
  • Tubulin; Inhibitor Of Cell Proliferation; For Drug Screening
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Cell Targeting Vectors Containing A Dna Sequence Encoding A Single Chain Antibody Fragment Having A Specific Amino Acid Sequence And May Further Contain A Dna Sequence Encoding A Spleen Necrosis Virus Env Leader; Used In Particular For The Therapy Of T-Cell-Associated Diseases.
  • Ultrasound Catheter
  • Infectivity-Enhanced Conditionally-Replicative Adenovirus And Uses Thereof
  • Modified Polynucleotides For The Production Of G-Csf
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Synthetic Genes And Genetic Constructs Comprising Same I
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Therapy For Brain Disorders
  • Influenza Virus Replication For Vaccine Development
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Polymerase Iii-Based Expression Of Therapeutic Rnas
  • Methods Of Treating Parkinson's Disease Using Viral Vectors
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Peptide Vector
  • Fibroblast Growth Factor-Like Polypeptides And Variants Thereof
  • Ultrasound Catheter For Providing A Therapeutic Effect To A Vessel Of A Body
  • Using Rna Interference As Therapeutic Tool In Treatment Of Metabolic Disorders; Tissue Directed Therapy
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Conformationally Constrained Parthyroid Hormone (Pth) Analogs
  • Method Of Differentiating Umbilical Cord Tissue Into A Chondrogenic Phenotype
  • Adenovirus Vectors Containing Cell Status-Specific Response Elements And Methods Of Use Thereof
  • Using Artificial Bacterial Chromosome And Homologous Recombination As Tools For Stable Transfer Of Genetic Material Into Cells; Gene Replacement; Transgenic Animal Models
  • Mast Cell Rasgrp4 Compositions And Related Methods
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Methods For Administration Of Recombinant Gene Delivery Vehicles For Treatment Of Hemophilia And Other Disorders
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Expression Of Fusion Proteins
  • Fgf21 Mutant Fusion Polypeptides And Uses Thereof
  • Novel Inducible Animal Models Of Stress Behavior
  • For Developing Products Useful In Neuronal Regeneration And In Treatment Of Various Neurological Disorders, Including Dns Tumor
  • Vascular Disease That Involves Modifying Smooth Muscle Cells To Express A Gene Encoding A Protein Having Both Anti-Inflammatory And Pro-Apoptotic Activity. Preferably, The Protein Of The Invention Also Has An Anti-Proliferative Effect
  • Stimulating Formation Of An Inner Ear Sensory Hair Cell For Treatment Of Sensorineuronal Hearing Loss; Deafness
  • Application Of Mrna For Use As A Therapeutic Against Tumour Diseases
  • Immunotherapy Regimes Dependent On Apoe Status
  • Poliovirus Replicons Encoding Therapeutic Agents And Uses Thereof
  • Gene Delivery System And Methods Of Use
  • J Chain Or Portion Thereof Linked To At Least One Enzyme Inhibitor; Specifically Binds To Basolateral Factor; Eradi-Cation Of Metastatic Or Nonpolarized Cells; Lung, Breast, Colon, Ovarian And Prostate Carcinoma And Endometriosis
  • Methods And Compositions For Modulating Pd1
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Preparing A Suppression Effector And Replacement Nucleic Acid That Have Modifications In One Or More Third Base (Wobble) Positions So That Replacement Nucleic Acids Still Code For The Wild Type Or Equivalent Amino Acids
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • Postpartum Cells Derived From Umbilical Tissue And Methods Of Making And Using The Same
  • 3-Allyl-Rapamycin, 3-Methallyl-Rapamycin; C3-Substituted Rapamycin Rapalogs; Multimerizing Chimeric Proteins In Engineered Cells; Reduced Immunosuppressive Effect; Gene Therapy; Form A Tripartite Complex With Fkbp12 And A Genetically Engineered Frb Domain, Or Fusion Proteins Having Fkbp And Frb Domains
  • Nucleotide Sequence Which Encodes G-Protein Coupled Receptor; For The Treatment And Prevention Of Bacterial, Fungal, Protozoan And Viral Infections; For Use In Gene Therapy
  • Method For Providing Phototherapy To The Brain
  • Oxidized Lipids And Uses Thereof In The Treatment Of Inflammatory Diseases And Disorders
  • Ablation Of The Skin With An Electric Current From Treatment Electrodes, Then Using Iontophoresis, Electroosmosis, Iontophoresis, Electroporation, Phonophoresis, Pressure, Heat And/Or Concentration Gradients, To Move Drugs Through The Skin Or Mucous Membranes
  • Inhibitors Of Cyclin-Dependent Kinases (Cdks), Particularly Cdk/Cyclin Complexes, Can Be Used To Control Proliferation And/Or Differentiation Of Cells
  • Nucleic Acid Sequence Which, When Generates Mrna Which Anneals With Mrna Stranscrip From Hiv-1 Provirus Encoding Env, Pol, And/Or Gag Proteins
  • Human Plasma Hyaluronidase
  • Rna Interference Mediating Small Rna Molecules
  • Repair And Regeneration Of Renal Tissue Using Human Umbilical Cord Tissue-Derived Cells
  • Stable Formulations Of Purified Proteins
  • Immunostimulant (Monophosphoryl Lipid A, 3-De-O-Acylated Monophosphoryl Lipid A Or A Saponin) That Induces A Predominantly Th1-Type Immune Response And A Specific Polypeptide That Stimulates A Human Cytotoxic T Lymphocyte Response To It; Immunostimulant May Be An Adjuvant
  • Method To Detect Prostate Cancer In A Sample
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Transcriptional Activators, And Compositions And Uses Related Thereto
  • Differentiation Of Mutz-3 Cells To Produce Effective Dendritic Cells
  • Stabilized Liquid Anti-Rsv Antibody Formulations
  • Methods And Compositions For Treating Inflammatory Conditions
  • Vaccines Comprising Mutant Attenuated Influenza Viruses
  • Cancer Treatment With Endothelin Receptor Antagonists
  • Isolated Human Cell With An Inactivated Glucocorticoid Receptor Gene
  • Methods And Compositions For Modulating Pd1
  • Compositions, Systems And Methods For Cell Therapy
  • Vascular Endothelial Growth Factor 2
  • Methods And Compositions For Genomic Modification
  • Bovine Adeno-Associated Viral (Baav) Vector And Uses Thereof
  • Methods For Producing And Using In Vivo Pseudotyped Retroviruses Using Envelope Glycoproteins From Lymphocytic Choriomeningitis Virus (Lcmv)
  • Heat Shock Proteins Linked To Polynucleotide Encoding Hiv-Tat Transactivating Factor, Which Activates Hiv-2 Promoter
  • Adenoviral Vector Encoding Anti-Apoptotic Bcl-2 Gene And Uses Thereof
  • High Potency Sirnas For Reducing The Expression Of Target Genes
  • Novel Nucleic Acid Molecules; Immunospecifically Binding Respiratory Syncytial Virus (Rsv) Antigens; Long Half Life; Reduced Dosage And Side Effects
  • Transferring Nucleotide Sequences To Cells; Obtain Cells, Incubate With Delivery Agent, Expose To Nucleotide Sequences, Recover Transform Cells
  • Expression Vectors And Recombinant Virions Produced Using These Vectors, Which Include Genes Coding For Enzymes Defective Or Missing In Lysosomal Storage Disorders, Are Described. These Recombinant Aav Virions Are Useful In The
  • Bioconjugates And Delivery Of Bioactive Agents
  • Compositions And Methods For Modulating Vascularization
  • Method And Compounds For Controlling Capacitative Calcium Ion Entry Into Mammalian Cells
  • Conformationally Constrained Parathyroid Hormones With Alpha-Helix Stabilizers
  • Mesothelin Vaccines And Model Systems
  • C-Reactive Protein (Crp); Peptide Biodrugs Used To Reduce Body Weight, Adiposity, And Alleviate Insulin Resistance And Diabetes
  • Controlling Gene Expression
  • Modified Factor Viii
  • Thrombopoietic Compounds
  • Cytokines And Neuroantigens For Treatment Of Immune Disorders
  • Adenovirus Vector Comprising Transgene, Cardiomyocyte Restricted Ankyrin Repeat Protein Promoter, And Inverted Terminal Repeat Sequences From Human Adeno-Associated Virus
  • Materials And Methods For Prevention And Treatment Of Rna Viral Diseases
  • Alternating Modeling Of Chromatin In Cells; Genetic Engineering
  • Gene Therapy For Inhibition Of Angiogenesis
  • Expression Vector Having Structural Gene Linked To Chimeric Promoter Including Repressor Element Of Defined Nucleotide Sequence And Other Regulatory Sequences; Specific Delivery Of Anticarcinogenic/Antitumor/Antiproliferative Agents
  • Modulating Cellular Senescence In Vitro By Introducing A Polynucleotide (Gdna Or Cdna) Encoding An Amphiphysin-1 Protein; Genetic Engineering; Genetic Disorders, Premature Aging
  • Uses For Nucleic Acid Molecules In Detecting The Presence Of Pneumococcal Surface Protein C Or Of S.Pneumoniae By Detecting A Nucleic Acid Molecule Therefor In A Sample Such As By Amplification And/Or A Polymerase Chain Reaction
  • Expression Of Fusion Proteins
  • Administering At Site Of Excessive Vascular Smooth Muscle Cell Proliferation, An Isolated Human Gata-6 Nucleic Acid, To Reduce Or Prevent Excessive Vascular Smooth Muscle Cell Proliferation At The Site In Vivo; Treating Atherosclerosis
  • Interleukin-12 As An Adjuvant For Paramyxoviridae Vaccines
  • Selectively Replicating Viral Vectors
  • Means And Methods For Nucleic Acid Delivery Vehicle Design And Nucleic Acid Transfer
  • Adeno-Associated Vector Compositions For Expression Of Factor Viii
  • Applying Wound Healing Agents Comprising Nucleotide Sequences Codes For Platelet Derived Growth Factors(Pdgf), Keratinocyte Growth Factors(Kgf), Insulin Like Growth Factors(Igf) And Insulin Like Growth Factor Binding Proteins(Igfbp)
  • Expression Construct For Digesting Aggregating Protein And Method Of Inhibiting The Aggregation Of Aggregating Protein
  • Polynucleotide
  • Expression Cassette Vector; Polynucleotide Of Interest Linked To A Promoter, A Single Recombination Site, And A Hybrid Recombination Site; Facilitate Single Step Site Specific Recombination At An Endogenous Nucleic Acid Sequence
  • Modified Virus Vectors And Methods Of Making And Using The Same
  • Cartilage And Bone Repair And Regeneration Using Postpartum-Derived Cells
  • Humanized Anti-Ccr2 Antibodies And Methods Of Use Therefor
  • Increasing Bone Density
  • Methods And Compositions To Induce Antitumor Response
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Genetic Adjuvants For Immunotherapy
  • Compositions And Methods For The Induction And Tuning Of Gene Expression
  • Methods Of Stimulating Phagocytosis
  • Humanized Low Affinity Fcγr Mouse Cells
  • Rna Interference Mediating Small Rna Molecules
  • Neurotransmitter Transporter Sc6
  • Methods Of Increasing Rdcvf 1 Or Rdcvf 2 Polypeptides In Retinal Cells
  • Using Unidirectional Site-Specific Integrase To Generate Transgenic Cells; Genetic Engineering And Heterologous Gene Expression
  • Cell Lines
  • Liposomes Containing Therapeutic Genes Are Conjugated To Targeting Agents To Provide Transport Of Encapsulated Gene Across Blood-Retainal Barrier And Plasma Membrane Of Ocular Cell, Where This Gene Expresses Encoded Therapeutical Agent
  • Gene Therapy For Neurodegenerative Disorders
  • Method Of Reducing Neuronal Electrical Activity With A Potassium Channel Subunit
  • Methods Employing And Compositions Containing Defined Oxidized Phospholipids For Prevention And Treatment Of Atherosclerosis
  • Prostate Cancer Prognostic Compositions And Kits
  • Lentiviral Vectors
  • Nucleic Acid Compositions For Stimulating Immune Responses
  • Compositions And Methods For The Therapy And Diagnosis Of Prostate Cancer
  • Polynucleotides Encoding Low Density Lipoprotein Receptor
  • Polynucleotides Encoding Antigenic Hiv Type C Polypeptides, Polypeptides And Uses Thereof
  • Construction Of Fully-Deleted Adenovirus-Based Gene Delivery Vectors And Uses Thereof
  • Isolated Nucleic Acid Encoding Mucosa-Associated Lymphoid Tissue Malt-Lymphoma Associated Translocation (Mlt) Protein Comprising Specified Amino Acid Sequence
  • Gene Repair Involving In Vivo Excision Of Targeting Dna
  • Screening Method For Compounds That Promote Differentiation Of Inner Ear Progenitor Cells
  • Murb
  • Terminally Modified Rna
  • Pharmaceutical Composition Containing A Stabilised Mrna Optimised For Translation In Its Coding Regions
  • For Generating An Immune Response In A Subject; Synthetic Expression Cassettes Generated From These And Other Hiv Sequences; Vaccines; Immunogenic Hiv Gag Polypeptide
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Human Cytokine Polypeptide
  • Treatment Of Lung And Pulmonary Diseases And Disorders
  • Dock-And-Lock (Dnl) Constructs For Human Immunodeficiency Virus (Hiv) Therapy
  • Targeted Gene Delivery To Dendritic Cells
  • Methods And Means For Obtaining Modified Phenotypes
  • Methods And Compositions For Treatment Of Interferon-Resistant Tumors
  • Rna Interference Mediating Small Rna Molecules
  • Influenza B Virus Replication For Vaccine Development
  • Suppressor Of Ap-1
  • Using A Tyrosine Kinase Receptor Inhibitor
  • In Vivo Stimulation Of Angiogenic Activity
  • Methods And Means For Obtaining Modified Phenotypes
  • Methods Of Treating Metabolic Disease
  • Gene Delivery System And Methods Of Use
  • Administration Of An Effective Amount Of Nucleic Acid Molecules Encoding Interleukin-12 (Il-12), Interferon-Gamma (Ifn- Gamma ), And A Cytomegalo Virus Promoter Sequence To A Patient Suffering From Allergy, Atopic Dermatitis, Asthma, Allergic Sinusitis, Pulmonary Fibrosis, And Cancer.
  • Stable Lipid-Comprising Drug Delivery Complexes And Methods For Their Production
  • Osteopontin-Related Compositions And Methods
  • Rsv Specific Binding Molecule
  • Anti-Robo4 Antibodies And Uses Therefor
  • Lentiviral Ltr-Deleted Vector
  • Molecular Characterization Of Chromosome Translocation T(11;18)(Q21;Q21) And Its Correlation To Carcinogenesis
  • Methods For Producing Soluble, Biologically-Active Disulfide-Bond Containing Eukaryotic Proteins In Bacterial Cells
  • Induction Of Mucosal Tolerance To Antigens
  • Self-Replicating; Capable Of Systemic Infection In A Host; Contain Nucleic Acid Sequences Foreign To The Native Virus Which Are Transcribed Or Expressed In The Host; And Stable For The Transcription And Expression Of Foreign Nucleic Acids
  • Use Of Adenoviruses And Nucleic Acids That Code For Said Viruses
  • Human Plasma Hyaluronidase
  • Pin1 As A Marker For Abnormal Cell Growth
  • Nucleic Acid Constructs And Cells, And Methods Utilizing Same For Modifying The Electrophysiological Function Of Excitable Tissues
  • Primary Product In Which The Small Subunit Is N-Terminal To The Large Subunit
  • Trp8, A Transient Receptor Potential Channel Expressed In Taste Receptor Cells
  • Imunogenic A Beta Fragment Linked To Immunoglobulin Carrier To Form Conjugate; Adjuvant Comprising Antibodies To A Beta Fragment Enhances Immune Response; Alzheimer*S Disease Treatment
  • Administering Nucleic Acid To Stimunlate Immunology Response
  • Methods For Treating Tweak-Related Conditions
  • Long Terminal Repeat Sequence Linkage With Heterologous Dna And A Packaging Cell Line, For Infecting And Directing The Expression In The Selected Target Cells; Side Effect Reduction; Coding Melittin, Cecropin, Magainin As Antitumour, Antiviral, Antibacterial, Antifungal Agents; Biodrugs
  • Targeted Deletion Of Cellular Dna Sequences
  • Antibody Glycosylation Variants Having Increased Antibody-Dependent Cellular Cytotoxicity
  • Nucleic Acids Encoding Modulators Of Body Weight
  • Into A Mammalian Parenchymal Cell, By Complexing A Polynucleotide With A Nonviral Vector, Amphipathic Compounds, Or Polymer, Inserting Into A Mammalian Vessel, Increasing The Permeability Of The Vessel; Use In Gene Therapy
  • Compositions And Method For Non-Targeted Activation Of Endogenous Genes
  • Cryptosporidium Hominis Genes And Gene Products For Chemotherapeutic, Immunoprophylactic And Diagnostic Applications
  • In Vivo Selection Of Primitive Hematopoietic Cells
  • Methods And Compositions For Treating Abnormal Cell Growth Related To Unwanted Guanine Nucleotide Exchange Factor Activity
  • Anionic Charge-Dynamic Polymers For Release Of Cationic Agents
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Treating Brain Damage By Genetically Modifying Nestin-Positive Cells With C-Myc Oncogene; Differentiation; Stroke, Ischemia, Cerebral Palsy, Alzheimer's, Neurodegenerative Diseases, Dementia, Parkinson's, Huntington's Disease
  • Detection Of Genetic Lesions Used To Diagnose And Treat Central Nervous System Disorders Such As Epilepsy, Spinocerebellar Ataxia, Anxiety, Depression, Age-Related Memory Loss, Migraine, Obesity, Parkinsons Disease Or Alzheimer's Disease; Or Cardiovascular Disorders
  • P. Gingivalis Vaccine
  • Methods Of Delivering A Physiologically Active Polypeptide To A Mammal
  • Gene Transfer In Chickens By Introduction Of Dna Into Muscle In Ovo
  • Hybrid Compositions For Intracellular Targeting
  • Modified Polynucleotides Encoding Aquaporin-5
  • Method Of Treating Skin Ulcers With Vectors Encoding Hepatocyte Growth Factor
  • Membrane Active Polymers
  • Anionic Charge-Dynamic Polymers For Release Of Cationic Agents
  • Delivery Of Nucleic Acid Into Aquatic Animals
  • Gene Therapy For Neurodegenerative Disorders
  • A Dna Vector Delivery System Consisting Of A Cochleate Containing A Lipid Bilayer Element And Cations, Intergrative Proteins And Therapeutic Nucleotide Sequences; For Gene Therapy By Transducing Hematopoietic Stem Cells
  • Targeting Proteins To Deliver Therapeutic Or Diagnostic Reagents
  • Bioactive Peptides And Peptide Derivatives Of Parathyroid Hormone (Pth) And Parathyroid Hormone-Related Peptide (Pthrp)
  • Methods And Compositions For Inhibition Of Viral Replication
  • Microorganisms For Therapy
  • Methods Of Treating Of Diabetes And Obesity Using Fgf21 Mutants
  • Human Β-Adrenergic Receptor Kinase Polypeptide And Methods
  • Recombinant Adenovirus Using Liposome-Mediated Cotransfection And The Direct Observation Of A Cytopathic Effect In The Transfected Cells; Tumor Suppressor Gene
  • Antisense Modulation Of Ptp1b Expression
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Materials And Methods For Treatment Of Inflammatory And Cell Proliferation Disorders
  • Anaerobic Bacterium As A Drug For Cancer Gene Therapy
  • Polynucleotides Encoding Antigenic Hiv Type B Polypeptides, Polypeptides, And Uses Thereof
  • Modified Cytomegalovirus, The Modifications Include Adding Heterologus Sequence Enconding A Non-Viral Chemokine Element And/Or Immunogenic Polypeptide, And/Or Diabling A Viral Dissemination Gene
  • Dna Binding Proteins That Are Modified Such That They Are Stable Under Non-Hypoxic As Well As Hypoxic Conditions
  • Inhibition Of Stat3 Signal Transduction For Human Cancer Therapy
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Bovine Adenovirus Type 3 Genome And Vector Systems Derived Therefrom
  • A Biologically Active Peptide At Least 85% Identical To A Peptide: (A) X01valserglux02glnleux03hisx04x05glylysx06; (B) Fragments Containing Amino Acids 1-9, 1-10, 1-11, 1-12,(C) A Salt Or (D) N- Or C- Derivatives
  • Ribozyme Therapy For The Treatment Of Proliferative Skin And Eye Diseases
  • Methods And Reagents For Modulating Tgf-Β Superfamily Signaling
  • Methods For Producing Micrornas
  • Methods And Means For Obtaining Modified Phenotypes
  • Treating Biomaterial Using At Least One Electrical Field Generated By A First Voltage Pulse Which Is Terminated Once The Value For An Electrical Parameter Has Exceeded Or Dropped Below A Preset Limit; Successful Cell Treatment Can Be Ensured By Continuing The Terminated Voltage Pulse
  • Rsv-Specific Binding Molecule
  • Biodegradable Cationic Polymers
  • Culture Comprising Artificial Stroma Comprising Mixture Of Collagen, Human Fibroblasts From Colon Or Intestine; Overlayed With Epithelial Cells; And Growth Factor That Binds Receptors Of Insulin Growth Factor, Epidermal Growth Factor, And/Or Leukemia Inhibitory Factor; Drug Screening, Wound Healing
  • Nucleic Acid Compositions For Stimulating Immune Responses
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Stranded Rna Viruses And Process For The Production Of Such Viruses
  • Immunoaffinity Purification
  • Rapid In Vivo Identification Of Biologically Active Nucleases
  • Interferon Inducing Genetically Engineered Attenuated Viruses
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Rsv-Specific Binding Molecule
  • Comprising Adeno-Associated Virus Terminal Repeat Sequences; Intrastrand Base-Pairing
  • Recombinant Retrovirus Pseudotyped With A E2 Alphavirus Glycoprotein
  • Compositions And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis, And Abnormal Cell Proliferation
  • Stress-Phosphorylated Endoplasmic Reticulum Protein, Nogo B, For Therapy
  • Transgenic Human Cells Expressing Superantigens/Antiproliferative Agents For Use As Gene Therapeutic Tools In Cancer Treatment ; Tissue Engineering
  • Compositions And Methods For Elimination Of Unwanted Cells
  • Activator Of G Protein Signaling, Or ?Ags?; Recombinant Expression Vectors Containing A Nucleic Acid Molecule Of The Protein/Nucleic Acid
  • Binding Domains Of Proteins Of The Repulsive Guidance Molecule (Rgm) Protein Family And Functional Fragments Thereof, And Their Use
  • In Vivo Assay For Intravasation
  • Adeno-Associated Viral Vector For Use As Heterologous Gene Transfer Agent
  • Immunogenic Peptides For The Treatment Of Prostate And Breast Cancer
  • Targeted Chromosomal Genomic Alterations With Modified Single Stranded Oligonucleotides
  • Use Of Magnesium (Mg2+) For The Preparation Of A Therapeutic Composition For Transfection Of A Polynucleotide Into A Cell And Compositions Useful In Gene Therapy
  • Combination Of Dna Damaging Factors With The Heterologous Expression Of A Tumor Suppressor Gene Lead To A Pronounced Synergy Over And Above The Actions Of The Individual Components
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Treatment Of Immune Disease By Mucosal Delivery Of Antigens Using Genetically Modified Lactococcus
  • Liposome, A Ligand And A Polymeric Scaffold; Ligand Can Bind To A Cell Surface Receptor Or Molecule Expressed By The Target Cell
  • Self-Replicating Episomal Expression Vectors Conferring Tissue-Specific Gene Expression
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Methods And Compositions For Using Sax2
  • Use Of Decorin For Increasing Muscle Mass
  • Use Of Vegf-D Gene To Prevent Restenosis
  • Postpartum Cells Derived From Umbilical Cord Tissue, And Methods Of Making And Using The Same
  • Treatment Of Cerebral Amyloid Angiopathy
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Rsv-Specific Binding Molecules And Means For Producing Them
  • Modified Polynucleotides For The Production Of Proteins
  • Stimulating Formation Of An Inner Ear Sensory Hair Cell For Treatment Of Sensorineuronal Hearing Loss; Deafness
  • Nucleotide Sequences Comprising An Inverted Terminal Duplication And Heterologous Nucleotide Sequences; For The Treatment Of Genetic Disorders And Gene Therapy
  • Anti-Nucleolin Agent-Conjugated Nanoparticles
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Split Dose Administration
  • Administration Of Adenoviral Vectors; Correcting Defective Chloride Ion Transporters; Cystic Fibrosis
  • Complementing Cell Lines
  • Nucleic Acid Condensing Peptide, Nucleic Acid Condensing Peptide Set, Nucleic Acid Delivery Carrier, Nucleic Acid Delivery Method, Cell Production Method, Cell Detection Method And Kit
  • Polynucleotides Encoding A Super-Active Porcine Growth Hormone Releasing Hormone Analog
  • Sterilization; Contraceptives; Antitumor Agents; Viricides; Autoimmune Diseases
  • Submitting Cell To An Anti-Apoptotic Treatment With An Agent Comprising R1 Subunit Of Herpes Simplex Virus Ribonucleotide Reductase Enzyme Or A Nucleic Acid Encoding Said Enzyme To Prevent Apoptosis In Vitro
  • A Pseudotyped Feline Immunodeficiency Virus Virion; Transfection; Expression Vectors Packaged In Packaging Cells To Generate High Titer Recombinant Virus Stocks; Gene Therapy
  • Method Of Targeting Gene Delivery Using Viral Vectors
  • Include Recombinant Expression Constructs Containing Nucleic Acids Encoding Target Cell Surface Receptor Antigen And One Or More Immune Response Altering Molecules, Or The Expressed Products Themselves
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Packaging Cells For Producing Retrovirus Pseudotyped With An E2 Alphavirus Glycoprotein
  • Administration Of A Chemotherapeutic Agent And A Formulation Containing A Cationic Liposomes Which Consists Of Cationic Lipid, Phosphatidylcholine And Cholesterol And Having Encapsulated Therein An Oligonucleotide
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Soft Tissue Repair And Regeneration Using Postpartum-Derived Cells And Cell Products
  • Microorganisms Carrying A Tumor Antigen
  • Secreted Proteins
  • Methods For Modulating Bone Formation And Mineralization By Modulating Krc Activity
  • Il-17 Receptor A Antigen Binding Proteins
  • Nucleotide Sequences For Use As Tool In Controlling Protein Tyrosine Phosphatase-1b Gene Expression And Treatment Of Diabetes; Gene Expression Inhibition
  • Adenovirus Encoding Human Adenylylcyclase (Ac) Vi
  • Protein Which Does Not Hertero-Oligomerize With Native P53; Antitumor Agents
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Targeting Proteins To Deliver Therapeutic Or Diagnostic Reagents
  • Combination Enzyme Replacement And Small Molecule Therapy For Treatment Of Lysosomal Storage Diseases
  • Nucleotide Sequences Coding Low Density Lipoprotein Receptor-Related Protein 5 For Use As Tools In Diagnosis And Treatment Of Osteoporosis; High Bone Mass And Bone Disorders
  • Duplexed Parvovirus Vectors
  • Methods For Inducing Localized Vascular Development And Enhancing The Repair Of A Wound In The Mammamian Dermis
  • Retinal Dystrophy-Associated Protein And Uses Thereof
  • Treatment Of Copd, Gastro-Esophageal Reflux Disease (Gerd), Food Allergies And Other Gastrointestinal Conditions And Disorders Ameliorated By Proper Histamine Management Using A Combination Of Histidine Decarboxylase Inhibitors, Lra Drugs, Anti-H1 And/Or Anti-H2 Drugs
  • Cytokines And Neuroantigens For Treatment Of Immune Disorders
  • Cytokines And Neuroantigens For Treatment Of Immune Disorders
  • Methods Of Preventing And Treating Respiratory Viral Infection Using Immunomodulatory Polynucleotide Sequences
  • Adenoviruses Expressing Heterologous Tumor-Associated Antigens
  • Rna Interference Mediating Small Rna Molecules
  • Delivery Of Nucleic Acid Into Aquatic Animals
  • Gene Therapy For Neurodegenerative Disorders
  • Antibody Glycosylation Variants Having Increased Antibody-Dependent Cellular Cytotoxicity
  • Gene And Protein Relating To Hepatocellular Carcinoma And Methods Of Use Thereof
  • Methods And Compositions For The Inhibition Of Trpv4
  • A Dna Vector Delivery System Consisting Of A Cochleate Containing A Lipid Bilayer Element And Cations, Intergrative Proteins And Therapeutic Nucleotide Sequences; For Gene Therapy By Transducing Hematopoietic Stem Cells
  • Targeting Proteins To Deliver Therapeutic Or Diagnostic Reagents
  • Polynucleotide
  • Methods Of Treating Of Diabetes And Obesity Using Fgf21 Mutants
  • Human Β-Adrenergic Receptor Kinase Polypeptide And Methods
  • Antibody Constant Region Fused To An Ob Protein; Ditetics; Useful For Decreasing The Amount Of Insulin Necessary For The Treatment Of Diabetes
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Nucleotide Sequences Comprising An Inverted Terminal Duplication And Heterologous Nucleotide Sequences; For The Treatment Of Genetic Disorders And Gene Therapy
  • Delivery Of Multiple Genes To Cells Using Plural Adeno-Associated Viral Vectors
  • Activator Of G Protein Signaling, Or ?Ags?; Recombinant Expression Vectors Containing A Nucleic Acid Molecule Of The Protein/Nucleic Acid
  • Immunogenic Peptides For The Treatment Of Prostate And Breast Cancer
  • In Vivo Assay For Intravasation
  • Adeno-Associated Viral Vector For Use As Heterologous Gene Transfer Agent
  • Methods And Compositions For Inhibition Of Viral Replication
  • Microorganisms For Therapy
  • Lentiviral Triplex Dna, And Vectors And Recombinant Cells Containing Lentiviral Triplex Dna
  • Recombinant Retrovirus Pseudotyped With A E2 Alphavirus Glycoprotein
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Cdna Corresponding To The Antigenome Of Nonsegmented Negative Stranded Rna Viruses And Process For The Production Of Such Viruses
  • Immunoaffinity Purification
  • Interferon Inducing Genetically Engineered Attenuated Viruses
  • Rapid In Vivo Identification Of Biologically Active Nucleases
  • Polynucleotides Encoding Rod-Derived Cone Viability Factor (Rdcvf) And Methods Of Using The Same
  • Induction Of Mucosal Tolerance To Antigens
  • Targeted Chromosomal Genomic Alterations With Modified Single Stranded Oligonucleotides
  • Rsv-Specific Binding Molecule
  • Comprising Adeno-Associated Virus Terminal Repeat Sequences; Intrastrand Base-Pairing
  • Porcine Cells Comprising An Adenovirus E3 Gene Region
  • Modified Zinc Finger Binding Proteins
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Isolated Nucleic Acid Molecules Encoding A Herpesviridae Thymidine Kinase Enzyme Comprising One Or More Mutations, At Least One Of The Mutations Encoding An Amino Acid Substitution Upstream From A Drh Nucleoside Binding Site Which Increases A
  • Inducing A Reduced Lymphocyte Proliferative Response To A Major Histocomatibilty Complex (Mhc) Type Presented On An Human Embryonic Stem (Hes) Cell In A Subject; Induces A State Of Inflammatory Quiescence Or Immune Unresponsiveness, Which In Turn Enhances Engraftment Of The Stem Cells
  • Methods Useful For Generating Highly Mannosylated Pseudotyped Lentiviral Vector Particles Comprising A Vpx Protein
  • Repair And Regeneration Of Ocular Tissue Using Postpartum-Derived Cells
  • Recombiant Lentivirus Comprising An E2 Alphavirus Glycoprotein That Binds To Dc-Sign
  • Anti-Nucleolin Agent-Conjugated Nanoparticles
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Split Dose Administration
  • Secreted Proteins
  • Conditioned Media And Methods Of Making A Conditioned Media
  • Methods Of Transdifferentiation And Methods Of Use Thereof
  • Homodimeric Protein Constructs
  • Targeted Nucleic Acid Sequence Alteration Using Cells And Cell-Free Extracts With Altered Levels Or Activities Of A Protein From The Rad52 Epistasis Group, The Mismatch Repair Group And/Or The Excision Repair Group
  • Gene Therapy For Tumors Using Minus-Strand Rna Viral Vectors Encoding Immunostimulatory Cytokines
  • Metabolically Activated Recombinant Viral Vectors And Methods For Their Preparation And Use
  • Compositions And Methods For Activating Genes Of Interest
  • Adjustment Of Gene Expression
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Thrombopoietic Compounds
  • Cell Populations, Methods Of Transdifferentiation And Methods Of Use Thereof
  • Genetic Engineered Adeno-Associated Virus(Aav) Genetic Vectors Comprising Inverted Terminal Repeats Having Nucleotides Sequence Deletions And Replacements; Polynucleotides Used For Prophylaxis Of Liver Disorders
  • Compositions And Methods For The Therapeutic Use Of An Atonal-Associated Sequence For Deafness, Osteoarthritis, And Abnormal Cell Proliferation
  • Stress-Phosphorylated Endoplasmic Reticulum Protein, Nogo B, For Therapy
  • Use Of Decorin For Increasing Muscle Mass
  • Methods And Compositions For Using Sax2
  • Methods Of Modulating The Expression Of Genes Using Ultraspiracle Receptor
  • Synthetic Genes And Genetic Constructs
  • Mammalian Cell Which Can Package A Recombinant Adeno-Associated Virus (Aav) Vector At High Efficiency To Produce High Titers Of Recombinant Viral Particles
  • Infecting Animal Cells With Live Invasive Bacteria Containing A Eukaryotic Expression Cassette Encoding Gene, E.G., A Vaccine Antigen, An Therapeutic Agent, An Immunoregulatory Agent Or A Anti-Sense Rna Or A Catalytic Rna
  • Combination Of Dna Damaging Factors With The Heterologous Expression Of A Tumor Suppressor Gene Lead To A Pronounced Synergy Over And Above The Actions Of The Individual Components
  • Binding Domains Of Proteins Of The Repulsive Guidance Molecule (Rgm) Protein Family And Functional Fragments Thereof, And Their Use
  • Use Of Adenovirus And Nucleic Acids Coding Therefor
  • Self-Replicating Episomal Expression Vectors Conferring Tissue-Specific Gene Expression
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Treatment Of Immune Disease By Mucosal Delivery Of Antigens Using Genetically Modified Lactococcus
  • Liposome, A Ligand And A Polymeric Scaffold; Ligand Can Bind To A Cell Surface Receptor Or Molecule Expressed By The Target Cell
  • Therapeutic Retroviral Vectors For Gene Therapy
  • Distinguishing Pca3 Messenger Rna Species In Benign And Malignant Prostate Tissues
  • A Biologically Active Peptide At Least 85% Identical To A Peptide: (A) X01valserglux02glnleux03hisx04x05glylysx06; (B) Fragments Containing Amino Acids 1-9, 1-10, 1-11, 1-12,(C) A Salt Or (D) N- Or C- Derivatives
  • Ribozyme Therapy For The Treatment Of Proliferative Skin And Eye Diseases
  • Methods And Reagents For Modulating Tgf-Β Superfamily Signaling
  • Amyloid Peptide Inactivating Enzyme To Treat Alzheimer's Disease Peripherally
  • Nucleic Acid Condensing Peptide, Nucleic Acid Condensing Peptide Set, Nucleic Acid Delivery Carrier, Nucleic Acid Delivery Method, Cell Production Method, Cell Detection Method And Kit
  • Methods For Modulating Bone Formation And Mineralization By Modulating Krc Activity
  • Il-17 Receptor A Antigen Binding Proteins
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Nucleotide Sequences For Use As Tool In Controlling Protein Tyrosine Phosphatase-1b Gene Expression And Treatment Of Diabetes; Gene Expression Inhibition
  • Adenovirus Encoding Human Adenylylcyclase (Ac) Vi
  • Immuno Gene Therapy For Treatment Of Cancer And Hyperproliferative Diseases
  • Method For The Diagnosis And Prognosis Of Malignant Diseases
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Used To Reduce Resistance Of Cancer Cells To Treatment With An Anticancer Drug That Generates Oxidative Stress
  • Vaccine
  • Ace2 Activation For Treatment Of Heart, Lung And Kidney Disease And Hypertension
  • Compositions And Methods For Promoting Or Inhibiting Angiogenesis
  • Targeting Proteins To Deliver Therapeutic Or Diagnostic Reagents
  • Protein Which Does Not Hertero-Oligomerize With Native P53; Antitumor Agents
  • Combination Enzyme Replacement And Small Molecule Therapy For Treatment Of Lysosomal Storage Diseases
  • Nucleotide Sequences Coding Low Density Lipoprotein Receptor-Related Protein 5 For Use As Tools In Diagnosis And Treatment Of Osteoporosis; High Bone Mass And Bone Disorders
  • Genetically Engineered Swine Influenza Virus And Uses Thereof
  • Administration Of Adenoviral Vectors; Correcting Defective Chloride Ion Transporters; Cystic Fibrosis
  • Isolation, Purification Nucleic Acids; Dna Amplification In Sampling
  • Method Of Treating Skin Ulcers With Vectors Encoding Hepatocyte Growth Factor
  • Membrane Active Polymers
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Compositions Comprising Polynucleotides Encoding Rdcvf1 Or Rdcvf2
  • Lipid Complex; Drug Delivery; Gene Therapy
  • Modified Polynucleotides Encoding Aquaporin-5
  • Transgenic Animals And Cell Lines For Screening Drugs Effective For The Treatment Or Prevention Of Alzheimer's Disease
  • Osteoactivin Protein And Nucleic Acids Encoding The Same, Compositions And Methods Of Stimulating Bone Differentiation
  • Self-Replicating; Capable Of Systemic Infection In A Host; Contain Nucleic Acid Sequences Foreign To The Native Virus Which Are Transcribed Or Expressed In The Host; And Stable For The Transcription And Expression Of Foreign Nucleic Acids
  • Use Of Adenoviruses And Nucleic Acids That Code For Said Viruses
  • Methods For Producing Soluble, Biologically-Active Disulfide-Bond Containing Eukaryotic Proteins In Bacterial Cells
  • Immunologically Privileged Cells And Uses Thereof
  • Targeted Integration And Expression On Exogenous Nucleic Acid Sequences
  • Osteopontin-Related Compositions And Methods
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Anionic Charge-Dynamic Polymers For Release Of Cationic Agents
  • Nano-Enhanced Optical Delivery Of Exogenous Molecules To Cells And Tissues
  • Mutations That Confer Genetic Stability To Genes In Influenza Viruses
  • P. Gingivalis Vaccine
  • Methods Of Delivering A Physiologically Active Polypeptide To A Mammal
  • Charge-Dynamic Polymers And Delivery Of Anionic Compounds
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Prevention And Treatment Of Amyloidogenic Disease
  • Nanoparticle-Based Gene Delivery Systems
  • Combination Viral-Based And Gene-Based Therapy Of Tumors
  • Nucleotide Sequence Encoding The Enzyme I Scei And The Use Thereof
  • Nucleic Acid Molecules Comprising A Neocentromere
  • Modified Virus Vectors And Methods Of Making And Using The Same
  • Pca3, Pca3 Genes, And Methods Of Use
  • Tryptophan Containing Low Molecular Weight Polylysine, For Use In Receptor-Mediated And Nonreceptor-Mediated Gene Delivery, Both In Vivo And In Vitro
  • Combination Method For Treatment Of Cancer
  • Detecting An Inhibitor Of P53 Protein Degradation Comprising Providing A Cell Extract Containing One Or More P53 Protein Proteases; Capable Of Modulating Calpaine Activity
  • Synthetic Dna Of Ty5-6p And Derivatives; Integrate In Genome At Silent Chromatin And Like Regions; For Regulating Cell Life Span, Marking Cells, Gene Therapy Delivery And Identifing Genes Involved In Development And Aging
  • Expression Vector Coding Polypeptides For Use In The Treatment Of Alzheimer's Dieases And Tumors
  • Compositions And Methods For Treating Pancreatic Cancer
  • Anionic Charge-Dynamic Polymers For Release Of Cationic Agents
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Treating Brain Damage By Genetically Modifying Nestin-Positive Cells With C-Myc Oncogene; Differentiation; Stroke, Ischemia, Cerebral Palsy, Alzheimer's, Neurodegenerative Diseases, Dementia, Parkinson's, Huntington's Disease
  • Detection Of Genetic Lesions Used To Diagnose And Treat Central Nervous System Disorders Such As Epilepsy, Spinocerebellar Ataxia, Anxiety, Depression, Age-Related Memory Loss, Migraine, Obesity, Parkinsons Disease Or Alzheimer's Disease; Or Cardiovascular Disorders
  • Hair Follicle Dna Delivery System
  • Bioconjugates And Delivery Of Bioactive Agents
  • Antibody To Secreted Polypeptide
  • Preferential Translation Of Toxin; Anticancer Agents
  • Promoters Exhibiting Endothelial Cell Specificity And Methods Of Using Same For Regulation Of Angiogenesis
  • Glycosylation Engineering Of Antibodies For Improving Antibody-Dependent Cellular Cytotoxicity
  • Methods And Compositions For Treating Abnormal Cell Growth Related To Unwanted Guanine Nucleotide Exchange Factor Activity
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Regeneration And Repair Of Neural Tissue Using Postpartum-Derived Cells
  • Peptide Compositions And Their Use Against The Hepatitis C Virus
  • Comprise The Gene Of Interest; And A Viral Capsid Or Envelope Carrying A Member Of A Specific Binding Pair, The Counterpart Of Which Is Not Directly Associated With The Surface Of The Target Cell; Use In Gene Therapy
  • Gene Transfer Method
  • Gene Transfer In Chickens By Introduction Of Dna Into Muscle In Ovo
  • Synthetic Polymer Carrier Vehicle For Delivery Of Nucleic Acid To Target Cells In Biological Systems
  • Hybrid Compositions For Intracellular Targeting
  • Induction Of Mucosal Tolerance To Antigens
  • Polynucleotide Constructs, Pharmaceutical Compositions And Methods For Targeted Downregulations Of Angiogenesis And Anticancer Therapy
  • Methods Of Isolating Bipotent Hepatic Progenitor Cells
  • Nucleotide Sequences Coding Polypeptide For Use In The Treatment Of Cancer
  • Compositions And Methods For Non-Targeted Activation Of Endogenous Genes
  • An Immunogeniclly Effective Amount Of A Nuclic Acid Encoding A Relevant Epitope Of A Desired Target Antigen Is Administered To The Infant.
  • Human Plasma Hyaluronidase
  • Primary Product In Which The Small Subunit Is N-Terminal To The Large Subunit
  • Administering To Peripheral Neuron Cells A Neurotropic Viral (Herpes Simplex) Vector Which Contains Dna Sequence Linked To Lat Promoter; Expressing Beta -Glucuronidase In Brain
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/38410

    DOI

    http://dx.doi.org/10.1038/38410

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9305836


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