Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-10

AUTHORS

K Duff, C Eckman, C Zehr, X Yu, C M Prada, J Perez-tur, M Hutton, L Buee, Y Harigaya, D Yager, D Morgan, M N Gordon, L Holcomb, L Refolo, B Zenk, J Hardy, S Younkin

ABSTRACT

Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) are known to cause early-onset, autosomal dominant Alzheimer's disease. Studies of plasma and fibroblasts from subjects with these mutations have established that they all alter amyloid beta-protein (beta APP) processing, which normally leads to the secretion of amyloid-beta protein (relative molecular mass 4,000; M(r) 4K; approximately 90% A beta1-40, approximately 10% A beta1-42(43)), so that the extracellular concentration of A beta42(43) is increased. This increase in A beta42(43) is believed to be the critical change that initiates Alzheimer's disease pathogenesis because A beta42(43) is deposited early and selectively in the senile plaques that are observed in the brains of patients with all forms of the disease. To establish that the presenilin mutations increase the amount of A beta42(43) in the brain and to test whether presenilin mutations act as true (gain of function) dominants, we have now constructed mice expressing wild-type and mutant presenilin genes. Analysis of these mice showed that overexpression of mutant, but not wild-type, PS1 selectively increases brain A beta42(43). These results indicate that the presenilin mutations probably cause Alzheimer's disease through a gain of deleterious function that increases the amount of A beta42(43) in the brain. More... »

PAGES

710-713

Journal

TITLE

Nature

ISSUE

6602

VOLUME

383

Author Affiliations

From Grant

  • Related Patents

  • Interaction Test For The Investigation Of Inhibitory Molecules Of The Interaction Between A Presenilin And The Β-Amyloid Peptide
  • Proteins Related To Schizophrenia And Uses Thereof
  • Prevention And Treatment Of Amyloidgenic Disease
  • Histone Acetyltransferase Modulators And Uses Thereof
  • Leptin Compositions And Methods For Treating Progressive Cognitive Function Disorders Resulting From Accumulation Of Neurofibrillary Tangles And Amyloid Beta
  • Γ-Secretase Substrates And Methods Of Use
  • Treatment Of Amyloidogenic Diseases
  • Antibodies To Amyloid Beta
  • Prevention And Treatment Of Amyloidogenic Disease
  • Humanized Antibodies That Recognize Β-Amyloid Peptide
  • Prevention And Treatment Of Amyloidogenic Disease
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Humanized Aβ Antibodies For Use In Improving Cognition
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Regulation Of Amyloid Beta Molecular Composition For The Treatment Of Alzheimer's Disease
  • Gene-Targeted Non-Human Mammal With Human Fad Presenilin Mutation And Generational Offspring
  • Gene Mutant Animals
  • Treatment Of Amyloidogenic Diseases
  • Bri Constructs And Methods Of Using
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Model Cells Of Neurodegenerative Disease, Process For Production Of Same, And Use Of Same
  • Purified 20 Kda Presenilin 2 C-Terminal Fragment And Methods Of Screening For Compounds That Inhibit Proteolysis Of Presenilin 2
  • Transgenic Animal Expressing Non-Native Wild-Type And Familial Alzheimer's Disease Mutant Presenilin 1 Protein On Native Presenilin 1 Null Background
  • Hybrid Amyloid-Beta Antibodies
  • Phosphodiesterase Inhibitors And Uses Thereof
  • Method And Composition For Modulating Amyloidosis
  • Peptide Having Hydrolase Activity
  • Methods For Diagnosing A Neurodegenerative Condition
  • Transgenic Mice Expressing Appk670n,M671l And A Mutant Presenilin Transgenes
  • Phosphodiesterase Inhibitors And Uses Thereof
  • Method And Composition For Modulating Amyloidosis
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Immunological Targeting Of Pathological Tau Proteins
  • Helical Peptidomimetics With Enhanced Activity
  • Immunotherapy Regimes Dependent On Apoe Status
  • Phosphodiesterase Inhibitors And Uses Thereof
  • Prevention And Treatment Of Amyloidogenic Disease
  • Methods And Compositions For Gamma-Secretase Assay
  • Presenilin Associated Membrane Protein (Pamp) And Uses Thereof
  • Human Sel-10 Polypeptides And Polynucleotides That Encode Them
  • Gene-Targeted Non-Human Mammal With A Human Fad Presenilin Mutation And Generational Offspring
  • Prevention And Treatment Of Amyloidogenic Disease
  • Treatment Of Cerebral Amyloid Angiopathy
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Human Sel-10 Polypeptides And Polynucleotides That Encode Them
  • Leptin As An Anti-Amyloidogenic Biologic And Methods For Delaying The Onset And Reducing Alzheimer's Disease-Like Pathology
  • Humanized Antibodies That Recognize Beta Amyloid Peptide
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/383710a0

    DOI

    http://dx.doi.org/10.1038/383710a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044462663

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8878479


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid beta-Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutagenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptide Fragments", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Presenilin-1", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of South Florida", 
              "id": "https://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Suncoast Alzheimer's Disease Laboratories, University of South Florida, Tampa, 33612, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duff", 
            "givenName": "K", 
            "id": "sg:person.01152131746.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152131746.50"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Eckman", 
            "givenName": "C", 
            "type": "Person"
          }, 
          {
            "familyName": "Zehr", 
            "givenName": "C", 
            "id": "sg:person.014470267537.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470267537.48"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Yu", 
            "givenName": "X", 
            "id": "sg:person.01354555335.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354555335.38"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Prada", 
            "givenName": "C M", 
            "id": "sg:person.07533661324.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07533661324.30"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Perez-tur", 
            "givenName": "J", 
            "id": "sg:person.0752167650.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752167650.26"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Hutton", 
            "givenName": "M", 
            "id": "sg:person.012237777422.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012237777422.94"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Buee", 
            "givenName": "L", 
            "id": "sg:person.0774506073.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774506073.70"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Harigaya", 
            "givenName": "Y", 
            "id": "sg:person.0741037346.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741037346.48"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Yager", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "familyName": "Morgan", 
            "givenName": "D", 
            "id": "sg:person.015742624552.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015742624552.50"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Gordon", 
            "givenName": "M N", 
            "id": "sg:person.01220621725.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220621725.03"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Holcomb", 
            "givenName": "L", 
            "id": "sg:person.01014077107.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014077107.50"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Refolo", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "familyName": "Zenk", 
            "givenName": "B", 
            "id": "sg:person.0635012335.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635012335.13"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Hardy", 
            "givenName": "J", 
            "id": "sg:person.011567711257.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011567711257.54"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Younkin", 
            "givenName": "S", 
            "id": "sg:person.010050762037.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010050762037.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/375754a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007185513", 
              "https://doi.org/10.1038/375754a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.40.23243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008253004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373523a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010973433", 
              "https://doi.org/10.1038/373523a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.119.1.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013122704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410360307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014294402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/349704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019413791", 
              "https://doi.org/10.1038/349704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.13.7013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021717116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90223-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027894895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376775a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027907322", 
              "https://doi.org/10.1038/376775a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410370305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.3.836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036390164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80291-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040779300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377351a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041449841", 
              "https://doi.org/10.1038/377351a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00032a022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055157976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7638622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082628897", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1996-10", 
        "datePublishedReg": "1996-10-01", 
        "description": "Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) are known to cause early-onset, autosomal dominant Alzheimer's disease. Studies of plasma and fibroblasts from subjects with these mutations have established that they all alter amyloid beta-protein (beta APP) processing, which normally leads to the secretion of amyloid-beta protein (relative molecular mass 4,000; M(r) 4K; approximately 90% A beta1-40, approximately 10% A beta1-42(43)), so that the extracellular concentration of A beta42(43) is increased. This increase in A beta42(43) is believed to be the critical change that initiates Alzheimer's disease pathogenesis because A beta42(43) is deposited early and selectively in the senile plaques that are observed in the brains of patients with all forms of the disease. To establish that the presenilin mutations increase the amount of A beta42(43) in the brain and to test whether presenilin mutations act as true (gain of function) dominants, we have now constructed mice expressing wild-type and mutant presenilin genes. Analysis of these mice showed that overexpression of mutant, but not wild-type, PS1 selectively increases brain A beta42(43). These results indicate that the presenilin mutations probably cause Alzheimer's disease through a gain of deleterious function that increases the amount of A beta42(43) in the brain.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/383710a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7146585", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6602", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "383"
          }
        ], 
        "name": "Increased amyloid-\u03b242(43) in brains of mice expressing mutant presenilin 1", 
        "pagination": "710-713", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d3cacc1af40e490ff5844140b88af3abe70f3daaf0fe8bd43560f9b36dd7bc75"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8878479"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/383710a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044462663"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/383710a0", 
          "https://app.dimensions.ai/details/publication/pub.1044462663"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T12:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/383710a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/383710a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/383710a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/383710a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/383710a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    256 TRIPLES      21 PREDICATES      55 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/383710a0 schema:about N1d3de8e4906e4e16a5b52a33b70e043b
    2 N1d8918ce6614459c82703ea638c269b7
    3 N27c6ade0fe6b46039c61deb33950242e
    4 N316b910f74ce49f896abd93bd9c9f809
    5 N527fb0c28648448ba83bd29107d239a1
    6 N79cc6e1026294a5ebe3b015965cdcfc7
    7 N8390cfeded954ef99291d4ad9bef10af
    8 Nad21e9cb56284d158aa6071840fb3662
    9 Nd48fc11463a1471ca20c166933a92fef
    10 Ne4cbc9eb6d4e417fa71a62a8445040d5
    11 anzsrc-for:11
    12 anzsrc-for:1109
    13 schema:author Nee08d643f6bd4c30b1fe507f3999756c
    14 schema:citation sg:pub.10.1038/349704a0
    15 sg:pub.10.1038/373523a0
    16 sg:pub.10.1038/375754a0
    17 sg:pub.10.1038/376775a0
    18 sg:pub.10.1038/377351a0
    19 https://app.dimensions.ai/details/publication/pub.1082628897
    20 https://doi.org/10.1002/ana.410360307
    21 https://doi.org/10.1002/ana.410370305
    22 https://doi.org/10.1016/0092-8674(91)90223-l
    23 https://doi.org/10.1016/s0896-6273(00)80291-3
    24 https://doi.org/10.1021/bi00032a022
    25 https://doi.org/10.1073/pnas.85.3.836
    26 https://doi.org/10.1074/jbc.270.13.7013
    27 https://doi.org/10.1074/jbc.270.40.23243
    28 https://doi.org/10.1083/jcb.119.1.55
    29 https://doi.org/10.1126/science.7638622
    30 schema:datePublished 1996-10
    31 schema:datePublishedReg 1996-10-01
    32 schema:description Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) are known to cause early-onset, autosomal dominant Alzheimer's disease. Studies of plasma and fibroblasts from subjects with these mutations have established that they all alter amyloid beta-protein (beta APP) processing, which normally leads to the secretion of amyloid-beta protein (relative molecular mass 4,000; M(r) 4K; approximately 90% A beta1-40, approximately 10% A beta1-42(43)), so that the extracellular concentration of A beta42(43) is increased. This increase in A beta42(43) is believed to be the critical change that initiates Alzheimer's disease pathogenesis because A beta42(43) is deposited early and selectively in the senile plaques that are observed in the brains of patients with all forms of the disease. To establish that the presenilin mutations increase the amount of A beta42(43) in the brain and to test whether presenilin mutations act as true (gain of function) dominants, we have now constructed mice expressing wild-type and mutant presenilin genes. Analysis of these mice showed that overexpression of mutant, but not wild-type, PS1 selectively increases brain A beta42(43). These results indicate that the presenilin mutations probably cause Alzheimer's disease through a gain of deleterious function that increases the amount of A beta42(43) in the brain.
    33 schema:genre research_article
    34 schema:inLanguage en
    35 schema:isAccessibleForFree false
    36 schema:isPartOf N46dada7d62b74678a08bf6ce10895d7c
    37 N778f217d9ccd440ab10c6dae308d99fe
    38 sg:journal.1018957
    39 schema:name Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
    40 schema:pagination 710-713
    41 schema:productId N0d0b09feb3bf4d4a80df6bb6c8842cb5
    42 N309d2a1a17ba42dcab0e1df66d2840e2
    43 N337c19d0740d4d948fb32f541242905c
    44 N6eb04b884f644486a736368fa625f36b
    45 Ne3d57a2329eb4071959e852742b798a6
    46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044462663
    47 https://doi.org/10.1038/383710a0
    48 schema:sdDatePublished 2019-04-10T12:59
    49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    50 schema:sdPublisher Nd99d05062ad649d9ad23b560ebeb10d3
    51 schema:url http://www.nature.com/articles/383710a0
    52 sgo:license sg:explorer/license/
    53 sgo:sdDataset articles
    54 rdf:type schema:ScholarlyArticle
    55 N00e767dfdda9462a845dbf0b39f1353d rdf:first sg:person.0741037346.48
    56 rdf:rest N9962c42d015d48ad8861275d4ea63c72
    57 N0d0b09feb3bf4d4a80df6bb6c8842cb5 schema:name readcube_id
    58 schema:value d3cacc1af40e490ff5844140b88af3abe70f3daaf0fe8bd43560f9b36dd7bc75
    59 rdf:type schema:PropertyValue
    60 N1d3de8e4906e4e16a5b52a33b70e043b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    61 schema:name Amyloid beta-Peptides
    62 rdf:type schema:DefinedTerm
    63 N1d8918ce6614459c82703ea638c269b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Mutagenesis
    65 rdf:type schema:DefinedTerm
    66 N22c453847c454301b765c18350785cb8 rdf:first sg:person.010050762037.32
    67 rdf:rest rdf:nil
    68 N27c6ade0fe6b46039c61deb33950242e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Mice
    70 rdf:type schema:DefinedTerm
    71 N309d2a1a17ba42dcab0e1df66d2840e2 schema:name pubmed_id
    72 schema:value 8878479
    73 rdf:type schema:PropertyValue
    74 N316b910f74ce49f896abd93bd9c9f809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Peptide Fragments
    76 rdf:type schema:DefinedTerm
    77 N337c19d0740d4d948fb32f541242905c schema:name nlm_unique_id
    78 schema:value 0410462
    79 rdf:type schema:PropertyValue
    80 N3aee17f4011f4287957db4c810981fae rdf:first sg:person.012237777422.94
    81 rdf:rest Nd1421e61d2224fda8091667f97cf68d4
    82 N3db888d018cc40d181d1ed16fdadc5aa rdf:first sg:person.015742624552.50
    83 rdf:rest Ncf333332eaf44f47add792d8b8d1028c
    84 N46dada7d62b74678a08bf6ce10895d7c schema:volumeNumber 383
    85 rdf:type schema:PublicationVolume
    86 N527fb0c28648448ba83bd29107d239a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Animals
    88 rdf:type schema:DefinedTerm
    89 N564bbb5eda064ebe8d5b8e7b4bb8eeb3 rdf:first sg:person.0635012335.13
    90 rdf:rest Nbde8ae1905b14929b632eccd9b033039
    91 N5ae683100248450e989317355d9c08be rdf:first N64ed7faabb2a4e1a90f2adce7125369f
    92 rdf:rest N564bbb5eda064ebe8d5b8e7b4bb8eeb3
    93 N5b7305f480a442a1bbff2ebf342466e0 rdf:first sg:person.07533661324.30
    94 rdf:rest N96fa8649e96940378d79225d14fcc031
    95 N64ed7faabb2a4e1a90f2adce7125369f schema:familyName Refolo
    96 schema:givenName L
    97 rdf:type schema:Person
    98 N69259e6682fc4ea780696dcc92e2db44 schema:familyName Eckman
    99 schema:givenName C
    100 rdf:type schema:Person
    101 N6eb04b884f644486a736368fa625f36b schema:name dimensions_id
    102 schema:value pub.1044462663
    103 rdf:type schema:PropertyValue
    104 N706d2e9c37e04285942b68bf741c743e rdf:first sg:person.014470267537.48
    105 rdf:rest Nd714ea5f6121490b9eed506780f7cc42
    106 N778f217d9ccd440ab10c6dae308d99fe schema:issueNumber 6602
    107 rdf:type schema:PublicationIssue
    108 N79cc6e1026294a5ebe3b015965cdcfc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Presenilin-1
    110 rdf:type schema:DefinedTerm
    111 N8390cfeded954ef99291d4ad9bef10af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Humans
    113 rdf:type schema:DefinedTerm
    114 N9233e46e43a04c8bae1b0c76f25534a8 rdf:first N69259e6682fc4ea780696dcc92e2db44
    115 rdf:rest N706d2e9c37e04285942b68bf741c743e
    116 N96fa8649e96940378d79225d14fcc031 rdf:first sg:person.0752167650.26
    117 rdf:rest N3aee17f4011f4287957db4c810981fae
    118 N9962c42d015d48ad8861275d4ea63c72 rdf:first Nd8ba3b555f284504b9d132ef4ea4ce09
    119 rdf:rest N3db888d018cc40d181d1ed16fdadc5aa
    120 Nad21e9cb56284d158aa6071840fb3662 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Brain
    122 rdf:type schema:DefinedTerm
    123 Nbde8ae1905b14929b632eccd9b033039 rdf:first sg:person.011567711257.54
    124 rdf:rest N22c453847c454301b765c18350785cb8
    125 Ncf333332eaf44f47add792d8b8d1028c rdf:first sg:person.01220621725.03
    126 rdf:rest Nd895b362a326461084bd99b11ca22657
    127 Nd1421e61d2224fda8091667f97cf68d4 rdf:first sg:person.0774506073.70
    128 rdf:rest N00e767dfdda9462a845dbf0b39f1353d
    129 Nd48fc11463a1471ca20c166933a92fef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Mice, Transgenic
    131 rdf:type schema:DefinedTerm
    132 Nd714ea5f6121490b9eed506780f7cc42 rdf:first sg:person.01354555335.38
    133 rdf:rest N5b7305f480a442a1bbff2ebf342466e0
    134 Nd895b362a326461084bd99b11ca22657 rdf:first sg:person.01014077107.50
    135 rdf:rest N5ae683100248450e989317355d9c08be
    136 Nd8ba3b555f284504b9d132ef4ea4ce09 schema:familyName Yager
    137 schema:givenName D
    138 rdf:type schema:Person
    139 Nd99d05062ad649d9ad23b560ebeb10d3 schema:name Springer Nature - SN SciGraph project
    140 rdf:type schema:Organization
    141 Ne3d57a2329eb4071959e852742b798a6 schema:name doi
    142 schema:value 10.1038/383710a0
    143 rdf:type schema:PropertyValue
    144 Ne4cbc9eb6d4e417fa71a62a8445040d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Membrane Proteins
    146 rdf:type schema:DefinedTerm
    147 Nee08d643f6bd4c30b1fe507f3999756c rdf:first sg:person.01152131746.50
    148 rdf:rest N9233e46e43a04c8bae1b0c76f25534a8
    149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Medical and Health Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Neurosciences
    154 rdf:type schema:DefinedTerm
    155 sg:grant.7146585 http://pending.schema.org/fundedItem sg:pub.10.1038/383710a0
    156 rdf:type schema:MonetaryGrant
    157 sg:journal.1018957 schema:issn 0090-0028
    158 1476-4687
    159 schema:name Nature
    160 rdf:type schema:Periodical
    161 sg:person.010050762037.32 schema:familyName Younkin
    162 schema:givenName S
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010050762037.32
    164 rdf:type schema:Person
    165 sg:person.01014077107.50 schema:familyName Holcomb
    166 schema:givenName L
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014077107.50
    168 rdf:type schema:Person
    169 sg:person.01152131746.50 schema:affiliation https://www.grid.ac/institutes/grid.170693.a
    170 schema:familyName Duff
    171 schema:givenName K
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152131746.50
    173 rdf:type schema:Person
    174 sg:person.011567711257.54 schema:familyName Hardy
    175 schema:givenName J
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011567711257.54
    177 rdf:type schema:Person
    178 sg:person.01220621725.03 schema:familyName Gordon
    179 schema:givenName M N
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220621725.03
    181 rdf:type schema:Person
    182 sg:person.012237777422.94 schema:familyName Hutton
    183 schema:givenName M
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012237777422.94
    185 rdf:type schema:Person
    186 sg:person.01354555335.38 schema:familyName Yu
    187 schema:givenName X
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354555335.38
    189 rdf:type schema:Person
    190 sg:person.014470267537.48 schema:familyName Zehr
    191 schema:givenName C
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014470267537.48
    193 rdf:type schema:Person
    194 sg:person.015742624552.50 schema:familyName Morgan
    195 schema:givenName D
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015742624552.50
    197 rdf:type schema:Person
    198 sg:person.0635012335.13 schema:familyName Zenk
    199 schema:givenName B
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635012335.13
    201 rdf:type schema:Person
    202 sg:person.0741037346.48 schema:familyName Harigaya
    203 schema:givenName Y
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741037346.48
    205 rdf:type schema:Person
    206 sg:person.0752167650.26 schema:familyName Perez-tur
    207 schema:givenName J
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752167650.26
    209 rdf:type schema:Person
    210 sg:person.07533661324.30 schema:familyName Prada
    211 schema:givenName C M
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07533661324.30
    213 rdf:type schema:Person
    214 sg:person.0774506073.70 schema:familyName Buee
    215 schema:givenName L
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774506073.70
    217 rdf:type schema:Person
    218 sg:pub.10.1038/349704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019413791
    219 https://doi.org/10.1038/349704a0
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/373523a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010973433
    222 https://doi.org/10.1038/373523a0
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/375754a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007185513
    225 https://doi.org/10.1038/375754a0
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/376775a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027907322
    228 https://doi.org/10.1038/376775a0
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/377351a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041449841
    231 https://doi.org/10.1038/377351a0
    232 rdf:type schema:CreativeWork
    233 https://app.dimensions.ai/details/publication/pub.1082628897 schema:CreativeWork
    234 https://doi.org/10.1002/ana.410360307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014294402
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/ana.410370305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839592
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/0092-8674(91)90223-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1027894895
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/s0896-6273(00)80291-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040779300
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1021/bi00032a022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157976
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1073/pnas.85.3.836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036390164
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1074/jbc.270.13.7013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021717116
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1074/jbc.270.40.23243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008253004
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1083/jcb.119.1.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013122704
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1126/science.7638622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648264
    253 rdf:type schema:CreativeWork
    254 https://www.grid.ac/institutes/grid.170693.a schema:alternateName University of South Florida
    255 schema:name Suncoast Alzheimer's Disease Laboratories, University of South Florida, Tampa, 33612, USA.
    256 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...