Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-10

AUTHORS

M Goedert, R Jakes, M G Spillantini, M Hasegawa, M J Smith, R A Crowther

ABSTRACT

The paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer's disease. PHFs are composed of microtubule-associated protein tau, in a hyperphosphorylated state. Hyperphosphorylation of tau results in its inability to bind to microtubules and is believed to precede PHF assembly. However, it is unclear whether hyperphosphorylation of tau is either necessary or sufficient for PHF formation. Here we show that non-phosphorylated recombinant tau isoforms with three microtubule-binding repeats form paired helical-like filaments under physiological conditions in vitro, when incubated with sulphated glycosaminoglycans such as heparin or heparan sulphate. Furthermore, heparin prevents tau from binding to microtubules and promotes microtubule disassembly. Finally, we show that heparan sulphate and hyperphosphorylated tau coexist in nerve cells of the Alzheimer's disease brain at the earliest known stages of neurofibrillary pathology. These findings, with previous studies which show that heparin stimulates tau phosphorylation by a number of protein kinases, indicate that sulphated glycosaminoglycans may be a key factor in the formation of the neurofibrillary lesions of Alzheimer's disease. More... »

PAGES

550-553

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/383550a0

DOI

http://dx.doi.org/10.1038/383550a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042539440

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8849730


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