Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

Paul S. Danielian, Andrew P. McMahon

ABSTRACT

A SECRETED signalling molecule encoded by the Wnt-1 gene is required for development of the central nervous system. In mouse embryos homozygous for a Wnt-1-null allele, the midbrain and anterior hindbrain fail to develop1,2. This corresponds to the region where two transcription factors encoded by the mouse engrailed genes (En-1 and En-2) are normally expressed3,4. Studies of the Drosophila orthologue of Wnt-1, wingless, indicate that Wingless signal is required to maintain engrailed expression in neighbouring cells of the developing epidermis5–7. Here we report that expression of En-1 in the developing midbrain of Wnt-1-null embryos is sufficient to rescue early midbrain and anterior hindbrain development. This suggests that a key role of Wnt-1 signalling is to maintain En expression and that this aspect of the Wnt-1/engrailed interaction has been conserved from flies to mice. More... »

PAGES

332-334

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/383332a0

DOI

http://dx.doi.org/10.1038/383332a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047928821

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8848044


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