Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

M Ono, S Bolland, P Tempst, J V Ravetch

ABSTRACT

Immune complexes are potent activators of inflammatory cells, triggering effector responses through the crosslinking of Fc receptors (FcRs) such as Fc(epsilon)RI or Fc(gamma)RIII. On B cells and mast cells, immune complexes are also negative regulators of activation triggered by antigen and Fc receptors, a consequence of coligation of the B-cell antigen receptor or Fc(epsilon)RI, respectively, and the inhibitory receptor Fc(gamma)RIIB. Here we show that inhibitory signalling by Fc(gamma)RIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyrosine-phosphorylated 13-amino-acid inhibitory motif of Fc(gamma)RIIB in both B cells and mast cells. SHIP, by hydrolysing the 5-phosphate of phosphatidylinositol(3,4,5)P3 and inositol(1,3,4,5)P4, suggests a mechanism by which Fc(gamma)RIIB can inhibit calcium influx and downstream responses triggered by immune receptors. More... »

PAGES

263-266

Journal

TITLE

Nature

ISSUE

6597

VOLUME

383

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/383263a0

    DOI

    http://dx.doi.org/10.1038/383263a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048489084

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8805703


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