Role of inscuteable in orienting asymmetric cell divisions in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

R Kraut, W Chia, L Y Jan, Y N Jan, J A Knoblich

ABSTRACT

Drosophila neuroblasts and epithelial cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell. We demonstrate here that orientation of the mitotic spindle and correct localization of Numb and Prospero in these cells require the inscuteable gene. Moreover, ectopic expression of inscuteable in other epithelial cells leads to spindle reorientation. The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division. More... »

PAGES

50-55

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/383050a0

DOI

http://dx.doi.org/10.1038/383050a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042321695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8779714


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