Functional interaction of β-catenin with the transcription factor LEF-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

J Behrens, J P von Kries, M Kühl, L Bruhn, D Wedlich, R Grosschedl, W Birchmeier

ABSTRACT

The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell-adhesion molecules to the cytoskeleton, and they participate in the wnt/wingless signal pathway. Here we show, in a yeast two-hybrid screen, that the architectural transcription factor LEF-1 (for lymphoid enhancer-binding factor) interacts with beta-catenin. In mammalian cells, coexpressed LEF-1 and beta-catenin form a complex that is localized to the nucleus and can be detected by immunoprecipitation. Moreover, LEF-1 and beta-catenin form a ternary complex with DNA that splays an altered DNA bend. Microinjection of LEF-1 into XenoPus embryos induces axis duplication, which is augmented by interaction with beta-catenin. Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus. More... »

PAGES

638-642

Journal

TITLE

Nature

ISSUE

6592

VOLUME

382

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/382638a0

    DOI

    http://dx.doi.org/10.1038/382638a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002681668

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8757136


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