Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

T Bouwmeester, S Kim, Y Sasai, B Lu, E M De Robertis

ABSTRACT

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo. More... »

PAGES

595-601

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382595a0

DOI

http://dx.doi.org/10.1038/382595a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025634868

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8757128


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