Ontology type: schema:ScholarlyArticle
1996-08
AUTHORSJason Z. Morris, Heidi A. Tissenbaum, Gary Ruvkun
ABSTRACTA PHEROMONE-INDUCED neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence, age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision. More... »
PAGES536-539
http://scigraph.springernature.com/pub.10.1038/382536a0
DOIhttp://dx.doi.org/10.1038/382536a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8700226
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