A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-08

AUTHORS

Jason Z. Morris, Heidi A. Tissenbaum, Gary Ruvkun

ABSTRACT

A PHEROMONE-INDUCED neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence, age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision. More... »

PAGES

536-539

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382536a0

DOI

http://dx.doi.org/10.1038/382536a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044090038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8700226


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