Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

F Shibasaki, E R Price, D Milan, F McKeon

ABSTRACT

A new facet of calcium signalling involves the nuclear import of the NF-AT transcription factors from their dormant position in the cytoplasm. The protein phosphatase calcineurin appears to play an essential role in activating NF-AT nuclear import, as the calcineurin inhibitors cyclosporin A and FK506 block dephosphorylation and nuclear import of NF-AT (refs 4-7). Here we show that calcium signalling induces an association between NF-AT4 and calcineurin, and that these molecules are transported, as a complex, to the nucleus, where calcineurin continues to dephosphorylate NF-AT4. We propose that a nuclear complex of NF-AT4 and calcineurin maintains calcium signalling by counteracting a vigorous nuclear NF-AT kinase. More... »

PAGES

370-373

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382370a0

DOI

http://dx.doi.org/10.1038/382370a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031781423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8684469


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