Critical role for β7 integrins in formation of the gut-associated lymphoid tissue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

N Wagner, J Löhler, E J Kunkel, K Ley, E Leung, G Krissansen, K Rajewsky, W Müller

ABSTRACT

Immune defence against pathogens entering the gut is accomplished by lymphocytes in the gut-associated lymphoid tissue (GALT), a major compartment of the immune system. The GALT, comprising Peyer's patches, lamina propria lymphocytes and intra-epithelial lymphocytes of the intestine, is populated by lymphocytes that migrate there from the vasculature. Here we report that, in mice deficient for the beta7 integrin subfamily of adhesion molecules, the formation of the GALT is severely impaired. This is probably due to a failure of beta7-/- lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT. More... »

PAGES

366-370

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382366a0

DOI

http://dx.doi.org/10.1038/382366a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022036577

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8684468


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