Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

Alicia A. Russo, Philip D. Jeffrey, Andrea K. Patten, Joan Massagué, Nikola P. Pavletich

ABSTRACT

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A–cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 Å. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP. More... »

PAGES

325-331

Journal

TITLE

Nature

ISSUE

6589

VOLUME

382

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/382325a0

    DOI

    http://dx.doi.org/10.1038/382325a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009765412

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8684460


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