A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

Xiang-Jiao Yang, Vasily V. Ogryzko, Jun-ichi Nishikawa, Bruce H. Howard, Yoshihiro Nakatani

ABSTRACT

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase. More... »

PAGES

319-324

Journal

TITLE

Nature

ISSUE

6589

VOLUME

382

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/382319a0

    DOI

    http://dx.doi.org/10.1038/382319a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052095488

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8684459


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