A new member of the frizzled family from Drosophila functions as a Wingless receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

Purnima Bhanot, Marcel Brink, Cindy Harryman Samos, Jen-Chih Hsieh, Yanshu Wang, Jennifer P. Macke, Deborah Andrew, Jeremy Nathans, Roel Nusse

ABSTRACT

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules. More... »

PAGES

225-230

Journal

TITLE

Nature

ISSUE

6588

VOLUME

382

From Grant

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/382225a0

    DOI

    http://dx.doi.org/10.1038/382225a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048857666

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8717036


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