Characterization of a multicomponent receptor for GDNF View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

J J Treanor, L Goodman, F de Sauvage, D M Stone, K T Poulsen, C D Beck, C Gray, M P Armanini, R A Pollock, F Hefti, H S Phillips, A Goddard, M W Moore, A Buj-Bello, A M Davies, N Asai, M Takahashi, R Vandlen, C E Henderson, A Rosenthal

ABSTRACT

Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Despite the potential clinical and physiological importance of GDNF, its mechanism of action is unknown. Here we show that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-alpha) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity. We further demonstrate that GDNF promotes the formation of a physical complex between GDNFR-alpha and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. These findings support the hypothesis that GDNF uses a multi-subunit receptor system in which GDNFR-alpha and Ret function as the ligand-binding and signalling components, respectively. More... »

PAGES

80-83

Journal

TITLE

Nature

ISSUE

6586

VOLUME

382

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/382080a0

    DOI

    http://dx.doi.org/10.1038/382080a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013786629

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8657309


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