Renal and neuronal abnormalities in mice lacking GDNF View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

M W Moore, R D Klein, I Fariñas, H Sauer, M Armanini, H Phillips, L F Reichardt, A M Ryan, K Carver-Moore, A Rosenthal

ABSTRACT

Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic, spinal motor, cranial sensory, sympathetic, and hindbrain noradrenergic neurons, and is available to these cells in vivo. It is therefore considered a physiological trophic factor and a potential therapeutic agent for Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here we show that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons. These mice completely lack the enteric nervous system (ENS), ureters and kidneys. Thus GDNF is important for the development and/or survival of enteric, sympathetic and sensory neurons and the renal system, but is not essential for catecholaminergic neurons in the central nervous system (CNS). More... »

PAGES

76-79

Journal

TITLE

Nature

ISSUE

6586

VOLUME

382

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382076a0

DOI

http://dx.doi.org/10.1038/382076a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022258141

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8657308


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