Defects in enteric innervation and kidney development in mice lacking GDNF View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

J G Pichel, L Shen, H Z Sheng, A C Granholm, J Drago, A Grinberg, E J Lee, S P Huang, M Saarma, B J Hoffer, H Sariola, H Westphal

ABSTRACT

Glial-lial-cell-line-derived neurotrophic factor (GDNF) has been isolated as neurotrophic factor for midbrain dopaminergic neurons. Because of its neurotrophic activity on a wide range of neuronal populations in vitro and in vivo, GDNF is being considered as a potential therapeutic agent for neuronal disorders. During mammalian development, it is expressed not only in the nervous system, but also very prominently in the metanephric kidney and the gastrointestinal tract, suggesting possible functions during organogenesis. We have investigated the role of GDNF during development by generating a null mutation in the murine GDNF locus, and found that mutant mice show kidney agenesis or dysgenesis and defective enteric innervation. We demonstrate that GDNF induces ureter bud formation and branching during metanephros development, and is essential for proper innervation of the gastrointestinal tract. More... »

PAGES

73-76

Journal

TITLE

Nature

ISSUE

6586

VOLUME

382

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/382073a0

DOI

http://dx.doi.org/10.1038/382073a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026862564

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8657307


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