HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

T Dragic, V Litwin, G P Allaway, S R Martin, Y Huang, K A Nagashima, C Cayanan, P J Maddon, R A Koup, J P Moore, W A Paxton

ABSTRACT

The beta-chemokines MIP-1alpha, MIP-1beta and RANTES inhibit infection of CD4+ T cells by primary, non-syncytium-inducing (NSI) HIV-1 strains at the virus entry stage, and also block env-mediated cell-cell membrane fusion. CD4+ T cells from some HIV-1-exposed uninfected individuals cannot fuse with NSI HIV-1 strains and secrete high levels of beta-chemokines. Expression of the beta-chemokine receptor CC-CKR-5 in CD4+, non-permissive human and non-human cells renders them susceptible to infection by NSI strains, and allows env-mediated membrane fusion. CC-CKR-5 is a second receptor for NSI primary viruses. More... »

PAGES

667-673

Journal

TITLE

Nature

ISSUE

6584

VOLUME

381

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/381667a0

    DOI

    http://dx.doi.org/10.1038/381667a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029523781

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8649512


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/381667a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/381667a0'

    RDF/XML is a standard XML format for linked data.

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