Identification of a major co-receptor for primary isolates of HIV-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

H Deng, R Liu, W Ellmeier, S Choe, D Unutmaz, M Burkhart, P Di Marzio, S Marmon, R E Sutton, C M Hill, C B Davis, S C Peiper, T J Schall, D R Littman, N R Landau

ABSTRACT

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta. More... »

PAGES

661-666

Journal

TITLE

Nature

ISSUE

6584

VOLUME

381

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/381661a0

    DOI

    http://dx.doi.org/10.1038/381661a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053562821

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8649511


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