Identification of a major co-receptor for primary isolates of HIV-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

HongKui Deng, Rong Liu, Wilfried Ellmeier, Sunny Choe, Derya Unutmaz, Michael Burkhart, Paola Di. Marzio, Shoshana Marmon, Richard E. Sutton, C. Mark Hill, Craig B. Davis, Stephen C. Peiper, Thomas J. Schall, Dan R. Littman, Nathaniel R. Landau

ABSTRACT

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β. More... »

PAGES

661-666

Journal

TITLE

Nature

ISSUE

6584

VOLUME

381

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/381661a0

    DOI

    http://dx.doi.org/10.1038/381661a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053562821

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8649511


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