Genetic modification of heterochromatic association and nuclear organization in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

A K Csink, S Henikoff

ABSTRACT

Heterochromatin is the highly compact, usually pericentromeric, region of eukaryotic chromosomes. Unlike the more gene-rich euchromatin, heterochromatin remains condensed during interphase, when it is sequestered to the periphery of the nucleus. Here we show, by using fluorescent in situ hybridization to interphase diploid nuclei of Drosophila, that the insertion of heterochromatin into a euchromatic gene, which results in position-effect variegation (PEV), also causes the aberrant association of the gene and its homologous copy with heterochromatin. In correlation with the gene's mutant variegating phenotype, the cytological association of the heterochromatic region is affected by chromosomal distance from heterochromatin and by genic modifiers of PEV. Proteins that are thought to be involved in the formation of heterochromatin can therefore influence the interphase nuclear position of a chromosomal region. This suggests that heterochromatin and proteins involved in its formation provide a structural framework for the interphase nucleus. More... »

PAGES

529-531

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/381529a0

DOI

http://dx.doi.org/10.1038/381529a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044866808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8632827


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