Crystal structure of a yeast TFIIA/TBP/DNA complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-05

AUTHORS

S Tan, Y Hunziker, D F Sargent, T J Richmond

ABSTRACT

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors. More... »

PAGES

127-134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/381127a0

DOI

http://dx.doi.org/10.1038/381127a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040648123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8610010


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