Role of intercellular interactions in heterosynaptic long-term depression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-04

AUTHORS

Massimo Scanziani, Robert C. Malenka, Roger A. Nicoll

ABSTRACT

BIDIRECTIONAL control of synaptic strength is thought to be important for the development of neuronal circuits and information storage. The demonstration of homosynaptic long-term depression1 greatly enhances the usefulness of the synapse as a mnemonic device, but theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in neuronal development2–4 and information storage5. Indeed, induction of long-term potentiation in one population of synapses can be associated with a modest depression at neighbouring inactive synapses in the same population of cells6–10. Here we report that in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property that its sites of induction and expression occur in different populations of cells and thus requires the spread of a signal between neurons. Such a mechanism ensures a widespread distribution of this form of plasticity. More... »

PAGES

446-450

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/380446a0

DOI

http://dx.doi.org/10.1038/380446a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050727319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8602244


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