Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-01

AUTHORS

M J Eck, S Pluskey, T Trüb, S C Harrison, S E Shoelson

ABSTRACT

The domain organization of many signalling proteins facilitates a segregation of binding, catalytic and regulatory functions. The mammalian SH2 domain protein tyrosine phosphatases (PTPs) contain tandem SH2 domains and a single carboxy-terminal catalytic domain. SH-PTP1 (PTP1C, HCP) and SH-PTP2 (Syp, PTP2C, PTP1D) function downstream from tyrosine kinase-linked insulin, growth factor, cytokine and antigen receptors. As well as directing subcellular localization by binding to receptors and their substrates, the two SH2 domains of these PTPs function together to regulate catalysis. Here we report the structure of the tandem SH2 domains of SH-PTP2 in complex with monophosphopeptides. A fixed relative orientation of the two domains, stabilized by a disulphide bond and a small hydrophobic patch within the interface, separates the peptide binding sites by approximately 40 A. The defined orientation of the SH2 domains in the structure, and data showing that peptide orientation and spacing between binding sites is critical for enzymatic activation, suggest that spatial constraints are important in this multidomain protein-protein interaction. More... »

PAGES

277-280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/379277a0

DOI

http://dx.doi.org/10.1038/379277a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004867089

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8538796


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disulfides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatase, Non-Receptor Type 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatase, Non-Receptor Type 6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SH2 Domain-Containing Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src Homology Domains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Boston Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Laboratory of Molecular Medicine, Children's Hospital, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eck", 
        "givenName": "M J", 
        "id": "sg:person.01212245744.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212245744.44"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pluskey", 
        "givenName": "S", 
        "id": "sg:person.0607065456.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607065456.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tr\u00fcb", 
        "givenName": "T", 
        "id": "sg:person.01275365604.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275365604.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Harrison", 
        "givenName": "S C", 
        "id": "sg:person.013635370377.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Shoelson", 
        "givenName": "S E", 
        "id": "sg:person.01021130270.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021130270.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/377032a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001223281", 
          "https://doi.org/10.1038/377032a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362087a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001978864", 
          "https://doi.org/10.1038/362087a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889888007903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002264445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373573a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008518821", 
          "https://doi.org/10.1038/373573a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767390010224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014210169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889891004399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014885043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9525(94)90149-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029393308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340110407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033493086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.340110407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033493086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90406-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034861692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.12.7577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038567724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90351-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043872677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.18.10498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048164586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-2126(00)00044-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048605018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.7.2897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050150675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7618087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7681217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7701328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7716523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8096088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05426.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076027782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082393660", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082464322", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082467503", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082671801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082839940", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-01", 
    "datePublishedReg": "1996-01-01", 
    "description": "The domain organization of many signalling proteins facilitates a segregation of binding, catalytic and regulatory functions. The mammalian SH2 domain protein tyrosine phosphatases (PTPs) contain tandem SH2 domains and a single carboxy-terminal catalytic domain. SH-PTP1 (PTP1C, HCP) and SH-PTP2 (Syp, PTP2C, PTP1D) function downstream from tyrosine kinase-linked insulin, growth factor, cytokine and antigen receptors. As well as directing subcellular localization by binding to receptors and their substrates, the two SH2 domains of these PTPs function together to regulate catalysis. Here we report the structure of the tandem SH2 domains of SH-PTP2 in complex with monophosphopeptides. A fixed relative orientation of the two domains, stabilized by a disulphide bond and a small hydrophobic patch within the interface, separates the peptide binding sites by approximately 40 A. The defined orientation of the SH2 domains in the structure, and data showing that peptide orientation and spacing between binding sites is critical for enzymatic activation, suggest that spatial constraints are important in this multidomain protein-protein interaction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/379277a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6562", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "379"
      }
    ], 
    "name": "Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2", 
    "pagination": "277-280", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "173141d6c2b89f6e001a944795c03b6c9969de9c85bc0f57adb9eddec18b164f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8538796"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/379277a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004867089"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/379277a0", 
      "https://app.dimensions.ai/details/publication/pub.1004867089"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/379277a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/379277a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/379277a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/379277a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/379277a0'


 

This table displays all metadata directly associated to this object as RDF triples.

238 TRIPLES      21 PREDICATES      72 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/379277a0 schema:about N104389edff7d45a1a2c62d7b5c55e411
2 N18fe5db6eb8d40cdaa9d2ba79acccd44
3 N1a72d74597c446b88f8fa64771d605f9
4 N275223b0acc548479c2d92406729dcac
5 N3f6ab82ab30c4c6baa04b4acd3486999
6 N4c7501ff0f4740619c328af6a731e374
7 N557902ad2c9540d098e9af5070a3ab9b
8 N781081ec6ee54f42968016afc419021a
9 N8467e87355524196a0d4d41e135780ea
10 N96467e8b973e4606a6ab59fdde9c4a7a
11 N9899f824ce004d44bce149033d29f289
12 N9c74372f409344b6990d120e2fe9ab08
13 Na40f32d085f94216a66b091e40b11dd8
14 Na48c365a19a344c3ace7bbee84c43be8
15 Nab7841ade12449c9a86154c1fc6dfcbd
16 Nd94de2a27f13428abc664ab68ededc9a
17 Nfdd1bc3a254c49e2a70afcad2c300fe2
18 Nff5e378f77774d6293ea019f847f5326
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author Nef355737381b4e3aa06216a18ccd6f16
22 schema:citation sg:pub.10.1038/362087a0
23 sg:pub.10.1038/373573a0
24 sg:pub.10.1038/377032a0
25 https://app.dimensions.ai/details/publication/pub.1082393660
26 https://app.dimensions.ai/details/publication/pub.1082464322
27 https://app.dimensions.ai/details/publication/pub.1082467503
28 https://app.dimensions.ai/details/publication/pub.1082671801
29 https://app.dimensions.ai/details/publication/pub.1082839940
30 https://doi.org/10.1002/j.1460-2075.1992.tb05426.x
31 https://doi.org/10.1002/prot.340110407
32 https://doi.org/10.1016/0092-8674(95)90351-8
33 https://doi.org/10.1016/0092-8674(95)90406-9
34 https://doi.org/10.1016/0168-9525(94)90149-x
35 https://doi.org/10.1016/s0969-2126(00)00044-7
36 https://doi.org/10.1074/jbc.270.18.10498
37 https://doi.org/10.1074/jbc.270.7.2897
38 https://doi.org/10.1107/s0021889888007903
39 https://doi.org/10.1107/s0021889891004399
40 https://doi.org/10.1107/s0108767390010224
41 https://doi.org/10.1126/science.7618087
42 https://doi.org/10.1126/science.7681217
43 https://doi.org/10.1126/science.7701328
44 https://doi.org/10.1126/science.7716523
45 https://doi.org/10.1126/science.8096088
46 https://doi.org/10.1128/mcb.13.12.7577
47 schema:datePublished 1996-01
48 schema:datePublishedReg 1996-01-01
49 schema:description The domain organization of many signalling proteins facilitates a segregation of binding, catalytic and regulatory functions. The mammalian SH2 domain protein tyrosine phosphatases (PTPs) contain tandem SH2 domains and a single carboxy-terminal catalytic domain. SH-PTP1 (PTP1C, HCP) and SH-PTP2 (Syp, PTP2C, PTP1D) function downstream from tyrosine kinase-linked insulin, growth factor, cytokine and antigen receptors. As well as directing subcellular localization by binding to receptors and their substrates, the two SH2 domains of these PTPs function together to regulate catalysis. Here we report the structure of the tandem SH2 domains of SH-PTP2 in complex with monophosphopeptides. A fixed relative orientation of the two domains, stabilized by a disulphide bond and a small hydrophobic patch within the interface, separates the peptide binding sites by approximately 40 A. The defined orientation of the SH2 domains in the structure, and data showing that peptide orientation and spacing between binding sites is critical for enzymatic activation, suggest that spatial constraints are important in this multidomain protein-protein interaction.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N4af65c2f91d647f4a0b4baebda33096a
54 N9a634cfe9d3b4758a484f3a00dfab9ec
55 sg:journal.1018957
56 schema:name Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
57 schema:pagination 277-280
58 schema:productId N4209d81473554fdeba08a018d9da1845
59 N47b18a3feb24436c87577d07fb7fff08
60 N4b7b53b504ae456a88bef6111cba55b6
61 N726687452fce451f8e81a20cfe6b7c27
62 Ndfa9bf7664c64149b0dd6f739c5d980d
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004867089
64 https://doi.org/10.1038/379277a0
65 schema:sdDatePublished 2019-04-10T16:28
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N18f56756dcd84bd9b57a9e1fca0d0ef9
68 schema:url http://www.nature.com/articles/379277a0
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N102bc308b62b4a079ec6d11808f0119e rdf:first sg:person.01021130270.20
73 rdf:rest rdf:nil
74 N104389edff7d45a1a2c62d7b5c55e411 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Models, Molecular
76 rdf:type schema:DefinedTerm
77 N18f56756dcd84bd9b57a9e1fca0d0ef9 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N18fe5db6eb8d40cdaa9d2ba79acccd44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Crystallography, X-Ray
81 rdf:type schema:DefinedTerm
82 N1a72d74597c446b88f8fa64771d605f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name src Homology Domains
84 rdf:type schema:DefinedTerm
85 N275223b0acc548479c2d92406729dcac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N3f6ab82ab30c4c6baa04b4acd3486999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Protein Tyrosine Phosphatases
90 rdf:type schema:DefinedTerm
91 N4209d81473554fdeba08a018d9da1845 schema:name readcube_id
92 schema:value 173141d6c2b89f6e001a944795c03b6c9969de9c85bc0f57adb9eddec18b164f
93 rdf:type schema:PropertyValue
94 N47b18a3feb24436c87577d07fb7fff08 schema:name doi
95 schema:value 10.1038/379277a0
96 rdf:type schema:PropertyValue
97 N4af65c2f91d647f4a0b4baebda33096a schema:issueNumber 6562
98 rdf:type schema:PublicationIssue
99 N4b7b53b504ae456a88bef6111cba55b6 schema:name dimensions_id
100 schema:value pub.1004867089
101 rdf:type schema:PropertyValue
102 N4c7501ff0f4740619c328af6a731e374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name SH2 Domain-Containing Protein Tyrosine Phosphatases
104 rdf:type schema:DefinedTerm
105 N557902ad2c9540d098e9af5070a3ab9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Protein Conformation
107 rdf:type schema:DefinedTerm
108 N726687452fce451f8e81a20cfe6b7c27 schema:name pubmed_id
109 schema:value 8538796
110 rdf:type schema:PropertyValue
111 N781081ec6ee54f42968016afc419021a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Intracellular Signaling Peptides and Proteins
113 rdf:type schema:DefinedTerm
114 N7df366b93e424eaeab282f3e6cc5b95f rdf:first sg:person.01275365604.11
115 rdf:rest Ndc47432b22b841f5b4bc4a27eeb486f0
116 N8467e87355524196a0d4d41e135780ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Molecular Sequence Data
118 rdf:type schema:DefinedTerm
119 N96467e8b973e4606a6ab59fdde9c4a7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphoproteins
121 rdf:type schema:DefinedTerm
122 N9899f824ce004d44bce149033d29f289 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Protein Tyrosine Phosphatase, Non-Receptor Type 6
124 rdf:type schema:DefinedTerm
125 N9a634cfe9d3b4758a484f3a00dfab9ec schema:volumeNumber 379
126 rdf:type schema:PublicationVolume
127 N9c74372f409344b6990d120e2fe9ab08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Structure-Activity Relationship
129 rdf:type schema:DefinedTerm
130 Na40f32d085f94216a66b091e40b11dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Escherichia coli
132 rdf:type schema:DefinedTerm
133 Na48c365a19a344c3ace7bbee84c43be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Protein Tyrosine Phosphatase, Non-Receptor Type 11
135 rdf:type schema:DefinedTerm
136 Nab7841ade12449c9a86154c1fc6dfcbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Amino Acid Sequence
138 rdf:type schema:DefinedTerm
139 Nd94de2a27f13428abc664ab68ededc9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Protein Binding
141 rdf:type schema:DefinedTerm
142 Ndc47432b22b841f5b4bc4a27eeb486f0 rdf:first sg:person.013635370377.53
143 rdf:rest N102bc308b62b4a079ec6d11808f0119e
144 Ndfa9bf7664c64149b0dd6f739c5d980d schema:name nlm_unique_id
145 schema:value 0410462
146 rdf:type schema:PropertyValue
147 Nef355737381b4e3aa06216a18ccd6f16 rdf:first sg:person.01212245744.44
148 rdf:rest Nff0d435eb54b477db49c241aefe5ba1f
149 Nfdd1bc3a254c49e2a70afcad2c300fe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Recombinant Proteins
151 rdf:type schema:DefinedTerm
152 Nff0d435eb54b477db49c241aefe5ba1f rdf:first sg:person.0607065456.17
153 rdf:rest N7df366b93e424eaeab282f3e6cc5b95f
154 Nff5e378f77774d6293ea019f847f5326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Disulfides
156 rdf:type schema:DefinedTerm
157 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
158 schema:name Biological Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biochemistry and Cell Biology
162 rdf:type schema:DefinedTerm
163 sg:journal.1018957 schema:issn 0090-0028
164 1476-4687
165 schema:name Nature
166 rdf:type schema:Periodical
167 sg:person.01021130270.20 schema:familyName Shoelson
168 schema:givenName S E
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021130270.20
170 rdf:type schema:Person
171 sg:person.01212245744.44 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
172 schema:familyName Eck
173 schema:givenName M J
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212245744.44
175 rdf:type schema:Person
176 sg:person.01275365604.11 schema:familyName Trüb
177 schema:givenName T
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275365604.11
179 rdf:type schema:Person
180 sg:person.013635370377.53 schema:familyName Harrison
181 schema:givenName S C
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53
183 rdf:type schema:Person
184 sg:person.0607065456.17 schema:familyName Pluskey
185 schema:givenName S
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607065456.17
187 rdf:type schema:Person
188 sg:pub.10.1038/362087a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001978864
189 https://doi.org/10.1038/362087a0
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/373573a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008518821
192 https://doi.org/10.1038/373573a0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/377032a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001223281
195 https://doi.org/10.1038/377032a0
196 rdf:type schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1082393660 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1082464322 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1082467503 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1082671801 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1082839940 schema:CreativeWork
202 https://doi.org/10.1002/j.1460-2075.1992.tb05426.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076027782
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/prot.340110407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033493086
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0092-8674(95)90351-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043872677
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0092-8674(95)90406-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034861692
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0168-9525(94)90149-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029393308
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0969-2126(00)00044-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048605018
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1074/jbc.270.18.10498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048164586
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1074/jbc.270.7.2897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050150675
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1107/s0021889888007903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002264445
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1107/s0021889891004399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014885043
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1126/science.7618087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648159
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1126/science.7681217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648379
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1126/science.7701328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648980
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1126/science.7716523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649028
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1126/science.8096088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652249
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1128/mcb.13.12.7577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038567724
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
237 schema:name Laboratory of Molecular Medicine, Children's Hospital, Boston, Massachusetts, USA.
238 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...