Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B View Full Text


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Article Info

DATE

1995-12

AUTHORS

D A Cross, D R Alessi, P Cohen, M Andjelkovich, B A Hemmings

ABSTRACT

Glycogen synthase kinase-3 (GSK3) is implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors AP-1 and CREB, the specification of cell fate in Drosophila and dorsoventral patterning in Xenopus embryos. GSK3 is inhibited by serine phosphorylation in response to insulin or growth factors and in vitro by either MAP kinase-activated protein (MAPKAP) kinase-1 (also known as p90rsk) or p70 ribosomal S6 kinase (p70S6k). Here we show, however, that agents which prevent the activation of both MAPKAP kinase-1 and p70S6k by insulin in vivo do not block the phosphorylation and inhibition of GSK3. Another insulin-stimulated protein kinase inactivates GSK3 under these conditions, and we demonstrate that it is the product of the proto-oncogene protein kinase B (PKB, also known as Akt/RAC). Like the inhibition of GSK3 (refs 10, 14), the activation of PKB is prevented by inhibitors of phosphatidylinositol (PI) 3-kinase. More... »

PAGES

785-789

Journal

TITLE

Nature

ISSUE

6559

VOLUME

378

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/378785a0

    DOI

    http://dx.doi.org/10.1038/378785a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042289302

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8524413


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