Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

Martin Turner, P. Joseph Mee, Patrick S. Costello, Owen Williams, Abigail A. Price, Linda P. Duddy, Michael T. Furlong, Robert L. Geahlen, Victor L. J. Tybulewicz

ABSTRACT

THE tyrosine kinase Syk (relative molecular mass 72,000), which is widely expressed in haematopoietic cells, becomes associated with and activated by engagement of the B-cell antigen receptor1,2. Furthermore, it has been implicated in signalling through the receptors for interleukin-2 (IL-2)3, granulocyte colony-stimulating factor (G-CSF)4 and Fc5, the T cell receptor, as well as through receptors for several platelet agonists7. A homologous kinase, ZAP-70, is crucial in signalling through the T-cell receptor and in T-cell development8,9. Using homologous recombination in embryonic stem cells, we created mice null for the syk gene which showed petechiae in utero and died shortly after birth. Irradiated mice reconstituted with Syk-deficient fetal liver showed a block in B-cell development at the pro-B to pre-B cell transition, consistent with a key role for Syk in pre-B-cell receptor signalling. Despite the production of small numbers of immature B cells, Syk-deficient radiation chimaeras failed to accumulate mature B cells, indicating a possible role for this protein in the production or maintenance of mature B cells. In addition, whereas the development of αβ T cells proceeded normally, Syk-deficient mice showed impaired development of thymocytes using the Vγ3 variable region gene (Vγ3+ thymocytes). Finally, we show that Syk is not required for signalling through the IL-2 and G-CSF receptors. More... »

PAGES

298-302

Journal

TITLE

Nature

ISSUE

6554

VOLUME

378

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/378298a0

DOI

http://dx.doi.org/10.1038/378298a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011405814

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7477352


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