Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

Joan Vaughan, Cynthia Donaldson, Jackson Bittencourt, Marilyn H. Perrin, Kathy Lewis, Steven Sutton, Raymond Chan, Andrew V. Turnbull, David Lovejoy, Catherine Rivier, Jean Rivier, Paul E. Sawchenko, Wylie Vale

ABSTRACT

Corticotropin-releasing factor (CRF), a peptide first isolated from mammalian brain, is critical in the regulation of the pituitary-adrenal axis, and in complementary stress-related endocrine, autonomic and behavioural responses. Fish urotensin I and amphibian sauvagine were considered to be homologues of CRF until peptides even more closely related to CRF were identified in these same vertebrate classes. We have characterized another mammalian member of the CRF family and have localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region. The deduced protein encodes a peptide that we name urocortin, which is related to urotensin (63% sequence identity) and CRF (45% sequence identity). Synthetic urocortin evokes secretion of adrenocorticotropic hormone (ACTH) both in vitro and in vivo and binds and activates transfected type-1 CRF receptors, the subtype expressed by pituitary corticotropes. The coincidence of urotensin-like immunoreactivity with type-2 CRF receptors in brain, and our observation that urocortin is more potent than CRF at binding and activating type-2 CRF receptors, as well as at inducing c-Fos (an index of cellular activation) in regions enriched in type-2 CRF receptors, indicate that this new peptide could be an endogenous ligand for type-2 CRF receptors. More... »

PAGES

287-292

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/378287a0

DOI

http://dx.doi.org/10.1038/378287a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008684402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7477349


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