Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

Celia M. Pombo, John H. Kehrl, Irma Sánchez, Paul Katz, Joseph Avruch, Leonard I. Zon, James R. Woodgett, Thomas Force, John M. Kyriakis

ABSTRACT

EUKARYOTIC cells respond to different extracellular stimuli by recruiting homologous signalling pathways that use members of the MEKK, MEK and ERK families of protein kinases. The MEKK→ MEK→ ERK core pathways of Saccharomyces cere-visiae may themselves be regulated by members of the STE20 family of protein kinases1,2. Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (GCK; ref. 3), a human STE20 homologue3,4. SAPKs, members of the ERK family, are activated in situ by inflammatory stimuli, including tumour-necrosis factor (TNF) and interleukin-1, and phosphorylate and probably stimulate the transactivation function of c-Jun5-7. Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal centre, where it may participate in B-cell differentiation3. Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20. More... »

PAGES

750-754

Journal

TITLE

Nature

ISSUE

6551

VOLUME

377

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/377750a0

DOI

http://dx.doi.org/10.1038/377750a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031048693

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7477268


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anisomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germinal Center Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pombo", 
        "givenName": "Celia M.", 
        "id": "sg:person.01101767143.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101767143.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Immunoregulation, NIAID, National Institutes of Health, Building 10, 10 Center Drive MSC 1876, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Immunoregulation, NIAID, National Institutes of Health, Building 10, 10 Center Drive MSC 1876, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kehrl", 
        "givenName": "John H.", 
        "id": "sg:person.010416624237.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010416624237.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez", 
        "givenName": "Irma", 
        "id": "sg:person.0671571352.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671571352.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Georgetown University Medical Center, 20007, Washington, DC, USA", 
          "id": "http://www.grid.ac/institutes/grid.411667.3", 
          "name": [
            "Department of Medicine, Georgetown University Medical Center, 20007, Washington, DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katz", 
        "givenName": "Paul", 
        "id": "sg:person.01151631125.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151631125.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avruch", 
        "givenName": "Joseph", 
        "id": "sg:person.01074100404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute and Division of Hematology/ Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Enders 650, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute and Division of Hematology/ Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Enders 650, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zon", 
        "givenName": "Leonard I.", 
        "id": "sg:person.015341736157.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woodgett", 
        "givenName": "James R.", 
        "id": "sg:person.0731233037.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Force", 
        "givenName": "Thomas", 
        "id": "sg:person.01053751523.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053751523.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyriakis", 
        "givenName": "John M.", 
        "id": "sg:person.01243062072.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243062072.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/372794a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539120", 
          "https://doi.org/10.1038/372794a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372739a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047199166", 
          "https://doi.org/10.1038/372739a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029771272", 
          "https://doi.org/10.1038/369156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372798a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022511929", 
          "https://doi.org/10.1038/372798a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367040a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021411105", 
          "https://doi.org/10.1038/367040a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-10", 
    "datePublishedReg": "1995-10-01", 
    "description": "EUKARYOTIC cells respond to different extracellular stimuli by recruiting homologous signalling pathways that use members of the MEKK, MEK and ERK families of protein kinases. The MEKK\u2192 MEK\u2192 ERK core pathways of Saccharomyces cere-visiae may themselves be regulated by members of the STE20 family of protein kinases1,2. Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (GCK; ref. 3), a human STE20 homologue3,4. SAPKs, members of the ERK family, are activated in situ by inflammatory stimuli, including tumour-necrosis factor (TNF) and interleukin-1, and phosphorylate and probably stimulate the transactivation function of c-Jun5-7. Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal centre, where it may participate in B-cell differentiation3. Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/377750a0", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7137801", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6551", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "377"
      }
    ], 
    "keywords": [
      "germinal center kinase", 
      "ERK family", 
      "SAPK pathway", 
      "stress-activated protein kinase pathway", 
      "different extracellular stimuli", 
      "first physiological function", 
      "protein kinase pathway", 
      "mammalian Ste20", 
      "striking conservation", 
      "eukaryotic cells", 
      "extracellular stimuli", 
      "Ste20 family", 
      "transactivation function", 
      "protein kinase", 
      "core pathways", 
      "kinase pathway", 
      "signaling mechanism", 
      "physiological functions", 
      "kinase", 
      "Ste20", 
      "pathway", 
      "specific activation", 
      "activation", 
      "tumor necrosis factor", 
      "family", 
      "MEKK", 
      "GCK", 
      "SAPK", 
      "cells", 
      "members", 
      "Saccharomyces", 
      "MEK", 
      "protein", 
      "inflammatory stimuli", 
      "conservation", 
      "expression", 
      "interleukin-1", 
      "function", 
      "lymphoid follicles", 
      "germinal centers", 
      "tissue", 
      "mechanism", 
      "stimuli", 
      "follicles", 
      "factors", 
      "situ", 
      "center"
    ], 
    "name": "Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase", 
    "pagination": "750-754", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031048693"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/377750a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7477268"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/377750a0", 
      "https://app.dimensions.ai/details/publication/pub.1031048693"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_269.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/377750a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/377750a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/377750a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/377750a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/377750a0'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      96 URIs      83 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/377750a0 schema:about N06af5d60859f4a4b89279dad4703c019
2 N20a705ef5b294a5e87f5c063cf1a46a3
3 N2ef0ed20e8a94093ad759accddb16e54
4 N43ebfa171baf4f599784e6783a02dbac
5 N48742401efff4be78cc30cf103b4770f
6 N4f21e515bebe485592dcc629d4fe9d0d
7 N694a029f88ae402984760e9ccba13d3e
8 N78f448ac22df4c68bc4c03f0d91b4e9b
9 N801b7d11789a4d168387ac45edd82e7d
10 N8297c28084e042f99d4491bf98df2087
11 Na2449b68babc45d98726c0b6837d4cce
12 Nad2125a6d89b4acfb18cd46af7244bbb
13 Nadabdb9b3d82474daa6eb1e24064ca98
14 Nd6833229df0e43ee8328080d64f1430d
15 Nd7aa8f6228a446168695dd35f64c1d25
16 Ndae606dfb0834d87867b4442a4f71cf7
17 Ndf548f105df34636bbdb4b7e657bd1ce
18 Nef91e562675648d1a93b68edb5688371
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N39dd0bdb02a74f7d9fcbe378b63c73b3
22 schema:citation sg:pub.10.1038/367040a0
23 sg:pub.10.1038/369156a0
24 sg:pub.10.1038/372739a0
25 sg:pub.10.1038/372794a0
26 sg:pub.10.1038/372798a0
27 schema:datePublished 1995-10
28 schema:datePublishedReg 1995-10-01
29 schema:description EUKARYOTIC cells respond to different extracellular stimuli by recruiting homologous signalling pathways that use members of the MEKK, MEK and ERK families of protein kinases. The MEKK→ MEK→ ERK core pathways of Saccharomyces cere-visiae may themselves be regulated by members of the STE20 family of protein kinases1,2. Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (GCK; ref. 3), a human STE20 homologue3,4. SAPKs, members of the ERK family, are activated in situ by inflammatory stimuli, including tumour-necrosis factor (TNF) and interleukin-1, and phosphorylate and probably stimulate the transactivation function of c-Jun5-7. Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal centre, where it may participate in B-cell differentiation3. Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N41ef4e065626469fb65e839532f14c27
33 Ndf759ac0d1484dbc9233952ffebb57cd
34 sg:journal.1018957
35 schema:keywords ERK family
36 GCK
37 MEK
38 MEKK
39 SAPK
40 SAPK pathway
41 Saccharomyces
42 Ste20
43 Ste20 family
44 activation
45 cells
46 center
47 conservation
48 core pathways
49 different extracellular stimuli
50 eukaryotic cells
51 expression
52 extracellular stimuli
53 factors
54 family
55 first physiological function
56 follicles
57 function
58 germinal center kinase
59 germinal centers
60 inflammatory stimuli
61 interleukin-1
62 kinase
63 kinase pathway
64 lymphoid follicles
65 mammalian Ste20
66 mechanism
67 members
68 pathway
69 physiological functions
70 protein
71 protein kinase
72 protein kinase pathway
73 signaling mechanism
74 situ
75 specific activation
76 stimuli
77 stress-activated protein kinase pathway
78 striking conservation
79 tissue
80 transactivation function
81 tumor necrosis factor
82 schema:name Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase
83 schema:pagination 750-754
84 schema:productId N5d8dd3e193574a528e821d15f5baf08a
85 Nc779c998030b446f82400302e6e955f3
86 Ncd5ca6d51f8b4c4182ed38ea974065da
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031048693
88 https://doi.org/10.1038/377750a0
89 schema:sdDatePublished 2022-09-02T15:47
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N12866df2fb2b4384b6289cb6d93df9f3
92 schema:url https://doi.org/10.1038/377750a0
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N06af5d60859f4a4b89279dad4703c019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Anisomycin
98 rdf:type schema:DefinedTerm
99 N12866df2fb2b4384b6289cb6d93df9f3 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N20a705ef5b294a5e87f5c063cf1a46a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Protein Serine-Threonine Kinases
103 rdf:type schema:DefinedTerm
104 N2ef0ed20e8a94093ad759accddb16e54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Saccharomyces cerevisiae
106 rdf:type schema:DefinedTerm
107 N39dd0bdb02a74f7d9fcbe378b63c73b3 rdf:first sg:person.01101767143.77
108 rdf:rest Nbba2c7af33a7452cba1b6599ea75c2fc
109 N408d9ca24507453881cb944915cb9039 rdf:first sg:person.0671571352.95
110 rdf:rest Nf8220c0ce376498693ec732a9066768e
111 N41ef4e065626469fb65e839532f14c27 schema:volumeNumber 377
112 rdf:type schema:PublicationVolume
113 N438bd08dc13246ad8bb7efd03e87a4ab rdf:first sg:person.01243062072.45
114 rdf:rest rdf:nil
115 N43ebfa171baf4f599784e6783a02dbac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Signal Transduction
117 rdf:type schema:DefinedTerm
118 N48742401efff4be78cc30cf103b4770f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Saccharomyces cerevisiae Proteins
120 rdf:type schema:DefinedTerm
121 N4f21e515bebe485592dcc629d4fe9d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Molecular Sequence Data
123 rdf:type schema:DefinedTerm
124 N5709a3422eb64a119e67f472d325ef41 rdf:first sg:person.015341736157.56
125 rdf:rest N902d7b8623a5443abd884a12b5974439
126 N5d8dd3e193574a528e821d15f5baf08a schema:name dimensions_id
127 schema:value pub.1031048693
128 rdf:type schema:PropertyValue
129 N5f70574a7fd04d03ae51645255143233 rdf:first sg:person.01053751523.10
130 rdf:rest N438bd08dc13246ad8bb7efd03e87a4ab
131 N694a029f88ae402984760e9ccba13d3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Tumor Cells, Cultured
133 rdf:type schema:DefinedTerm
134 N78f448ac22df4c68bc4c03f0d91b4e9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name MAP Kinase Kinase 4
136 rdf:type schema:DefinedTerm
137 N801b7d11789a4d168387ac45edd82e7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Line
139 rdf:type schema:DefinedTerm
140 N8297c28084e042f99d4491bf98df2087 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name DNA Primers
142 rdf:type schema:DefinedTerm
143 N902d7b8623a5443abd884a12b5974439 rdf:first sg:person.0731233037.88
144 rdf:rest N5f70574a7fd04d03ae51645255143233
145 Na2449b68babc45d98726c0b6837d4cce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Protein Kinases
147 rdf:type schema:DefinedTerm
148 Nad2125a6d89b4acfb18cd46af7244bbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Enzyme Activation
150 rdf:type schema:DefinedTerm
151 Nadabdb9b3d82474daa6eb1e24064ca98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Intracellular Signaling Peptides and Proteins
153 rdf:type schema:DefinedTerm
154 Nbba2c7af33a7452cba1b6599ea75c2fc rdf:first sg:person.010416624237.26
155 rdf:rest N408d9ca24507453881cb944915cb9039
156 Nc779c998030b446f82400302e6e955f3 schema:name pubmed_id
157 schema:value 7477268
158 rdf:type schema:PropertyValue
159 Ncd5ca6d51f8b4c4182ed38ea974065da schema:name doi
160 schema:value 10.1038/377750a0
161 rdf:type schema:PropertyValue
162 Nd2be1315596049988e7ee97464c725f4 rdf:first sg:person.01074100404.77
163 rdf:rest N5709a3422eb64a119e67f472d325ef41
164 Nd6833229df0e43ee8328080d64f1430d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mitogen-Activated Protein Kinase Kinases
166 rdf:type schema:DefinedTerm
167 Nd7aa8f6228a446168695dd35f64c1d25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Ndae606dfb0834d87867b4442a4f71cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Base Sequence
172 rdf:type schema:DefinedTerm
173 Ndf548f105df34636bbdb4b7e657bd1ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Germinal Center Kinases
175 rdf:type schema:DefinedTerm
176 Ndf759ac0d1484dbc9233952ffebb57cd schema:issueNumber 6551
177 rdf:type schema:PublicationIssue
178 Nef91e562675648d1a93b68edb5688371 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name MAP Kinase Kinase Kinases
180 rdf:type schema:DefinedTerm
181 Nf8220c0ce376498693ec732a9066768e rdf:first sg:person.01151631125.00
182 rdf:rest Nd2be1315596049988e7ee97464c725f4
183 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
184 schema:name Biological Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
187 schema:name Biochemistry and Cell Biology
188 rdf:type schema:DefinedTerm
189 sg:grant.7137801 http://pending.schema.org/fundedItem sg:pub.10.1038/377750a0
190 rdf:type schema:MonetaryGrant
191 sg:journal.1018957 schema:issn 0028-0836
192 1476-4687
193 schema:name Nature
194 schema:publisher Springer Nature
195 rdf:type schema:Periodical
196 sg:person.010416624237.26 schema:affiliation grid-institutes:grid.419681.3
197 schema:familyName Kehrl
198 schema:givenName John H.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010416624237.26
200 rdf:type schema:Person
201 sg:person.01053751523.10 schema:affiliation grid-institutes:grid.32224.35
202 schema:familyName Force
203 schema:givenName Thomas
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053751523.10
205 rdf:type schema:Person
206 sg:person.01074100404.77 schema:affiliation grid-institutes:grid.32224.35
207 schema:familyName Avruch
208 schema:givenName Joseph
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77
210 rdf:type schema:Person
211 sg:person.01101767143.77 schema:affiliation grid-institutes:grid.32224.35
212 schema:familyName Pombo
213 schema:givenName Celia M.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101767143.77
215 rdf:type schema:Person
216 sg:person.01151631125.00 schema:affiliation grid-institutes:grid.411667.3
217 schema:familyName Katz
218 schema:givenName Paul
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151631125.00
220 rdf:type schema:Person
221 sg:person.01243062072.45 schema:affiliation grid-institutes:grid.32224.35
222 schema:familyName Kyriakis
223 schema:givenName John M.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243062072.45
225 rdf:type schema:Person
226 sg:person.015341736157.56 schema:affiliation grid-institutes:grid.38142.3c
227 schema:familyName Zon
228 schema:givenName Leonard I.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56
230 rdf:type schema:Person
231 sg:person.0671571352.95 schema:affiliation grid-institutes:grid.32224.35
232 schema:familyName Sánchez
233 schema:givenName Irma
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671571352.95
235 rdf:type schema:Person
236 sg:person.0731233037.88 schema:affiliation grid-institutes:grid.415224.4
237 schema:familyName Woodgett
238 schema:givenName James R.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88
240 rdf:type schema:Person
241 sg:pub.10.1038/367040a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021411105
242 https://doi.org/10.1038/367040a0
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
245 https://doi.org/10.1038/369156a0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/372739a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047199166
248 https://doi.org/10.1038/372739a0
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/372794a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
251 https://doi.org/10.1038/372794a0
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/372798a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022511929
254 https://doi.org/10.1038/372798a0
255 rdf:type schema:CreativeWork
256 grid-institutes:grid.32224.35 schema:alternateName Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
257 Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
258 schema:name Cardiology Unit, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
259 Diabetes Research Laboratory, Massachusetts General Hospital East and Department of Medicine, Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
260 rdf:type schema:Organization
261 grid-institutes:grid.38142.3c schema:alternateName Howard Hughes Medical Institute and Division of Hematology/ Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Enders 650, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA
262 schema:name Howard Hughes Medical Institute and Division of Hematology/ Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Enders 650, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA
263 rdf:type schema:Organization
264 grid-institutes:grid.411667.3 schema:alternateName Department of Medicine, Georgetown University Medical Center, 20007, Washington, DC, USA
265 schema:name Department of Medicine, Georgetown University Medical Center, 20007, Washington, DC, USA
266 rdf:type schema:Organization
267 grid-institutes:grid.415224.4 schema:alternateName Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada
268 schema:name Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada
269 rdf:type schema:Organization
270 grid-institutes:grid.419681.3 schema:alternateName Laboratory of Immunoregulation, NIAID, National Institutes of Health, Building 10, 10 Center Drive MSC 1876, 20892, Bethesda, Maryland, USA
271 schema:name Laboratory of Immunoregulation, NIAID, National Institutes of Health, Building 10, 10 Center Drive MSC 1876, 20892, Bethesda, Maryland, USA
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...