Induction of the growth inhibitor IGF-binding protein 3 by p53 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

L Buckbinder, R Talbott, S Velasco-Miguel, I Takenaka, B Faha, B R Seizinger, N Kley

ABSTRACT

Transcriptional activation of target genes represents an important component of the tumour-suppressor function of p53 and provides a functional link between p53 and various growth-regulatory processes, including cell cycle progression (p21/WAF1), DNA repair (GADD45) and apoptosis (bax). Here we use a differential cloning approach to identify the gene encoding insulin-like growth factor binding protein 3 (IGF-BP3) as a novel p53-regulated target gene. Induction of IGF-BP3 gene expression by wild-type but not mutant p53 is associated with enhanced secretion of an active form of IGF-BP3 capable of inhibiting mitogenic signalling by the insulin-like growth factor IGF-1. Our results indicate that IGF-BP3 may link p53 to potential novel autocrine/paracrine signalling pathways and to processes regulated by or dependent on IGF(s), such as cellular growth, transformation and survival. More... »

PAGES

646

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/377646a0

DOI

http://dx.doi.org/10.1038/377646a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046371025

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7566179


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