A transcriptional co-repressor that interacts with nuclear hormone receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

J D Chen, R M Evans

ABSTRACT

Transcriptional silencing mediated by nuclear receptors is important in development, differentiation and oncogenesis. The mechanism underlying this effect is unknown but is one key to understanding the molecular basis of hormone action. Here we identify a receptor-interacting factor, SMRT, as a silencing mediator (co-repressor) for retinoid and thyroid-hormone receptors. SMRT is a previously undiscovered protein whose association with receptors both in solution and bound to DNA-response elements is destabilized by ligand. The interaction with mutant receptors correlates with their transcriptional silencing activities. In vivo, SMRT functions as a potent co-repressor, and a GAL4 DNA-binding domain fusion of SMRT behaves as a frank repressor of a GAL4-dependent reporter. Together, our results identify a new class of cofactors which may be important mediators of hormone action. More... »

PAGES

454-457

Journal

TITLE

Nature

ISSUE

6548

VOLUME

377

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/377454a0

    DOI

    http://dx.doi.org/10.1038/377454a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048833155

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7566127


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