Transcription complex stability and chromatin dynamics in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-09

AUTHORS

M Wijgerde, F Grosveld, P Fraser

ABSTRACT

Distant regulatory sequences affect transcription through long-range chromatin interactions. Visualization of transcriptional activity of genes that compete for distant elements, using the globin locus as a model, has revealed the dynamics of chromatin interactions in vivo. Multiple genes appear to be transcribed alternately rather than at the same time to generate several messenger RNAs in one cell. The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism. More... »

PAGES

209-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/377209a0

DOI

http://dx.doi.org/10.1038/377209a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026937730

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7675106


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