Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

S Kharbanda, R Ren, P Pandey, T D Shafman, S M Feller, R R Weichselbaum, D W Kufe

ABSTRACT

The product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing radiation activates c-Abl. Similar results were obtained with the alkylating agents cis-platinum and mitomycin C. We also demonstrate that cells deficient in c-Abl fail to activate Jun kinase (JNK/SAP kinase) after ionizing radiation or alkylating agent exposure and that reconstitution of c-Abl in these cells restores that response. In contrast, the stress response to tumour-necrosis factor is stimulated by a c-Abl-independent mechanism. These findings indicate that c-abl is involved in the stress response to DNA-damaging agents. More... »

PAGES

785-788

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/376785a0

DOI

http://dx.doi.org/10.1038/376785a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022545215

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7651539


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