Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

S Lev, H Moreno, R Martinez, P Canoll, E Peles, J M Musacchio, G D Plowman, B Rudy, J Schlessinger

ABSTRACT

The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system. More... »

PAGES

737-745

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/376737a0

DOI

http://dx.doi.org/10.1038/376737a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030681157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7544443


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Focal Adhesion Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GRB2 Adaptor Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kv1.2 Potassium Channel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PC12 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels, Voltage-Gated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "New York University Langone Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Department of Pharmacology, New York University Medical Center, New York 10016, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lev", 
        "givenName": "S", 
        "id": "sg:person.01013160164.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013160164.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Moreno", 
        "givenName": "H", 
        "id": "sg:person.01176202670.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176202670.81"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Martinez", 
        "givenName": "R", 
        "id": "sg:person.0745044764.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745044764.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Canoll", 
        "givenName": "P", 
        "id": "sg:person.01005455172.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005455172.89"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Peles", 
        "givenName": "E", 
        "id": "sg:person.01060417347.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060417347.88"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Musacchio", 
        "givenName": "J M", 
        "id": "sg:person.0777431622.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777431622.95"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Plowman", 
        "givenName": "G D", 
        "type": "Person"
      }, 
      {
        "familyName": "Rudy", 
        "givenName": "B", 
        "id": "sg:person.0677266502.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677266502.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Schlessinger", 
        "givenName": "J", 
        "id": "sg:person.0745312627.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745312627.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90419-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000550070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(91)90011-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003526172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(91)90011-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003526172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372786a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004642826", 
          "https://doi.org/10.1038/372786a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(91)90227-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006803577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369233a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013842356", 
          "https://doi.org/10.1038/369233a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90425-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015574980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(79)90093-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016794939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352026b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019715505", 
          "https://doi.org/10.1038/352026b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90167-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023123401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(90)90211-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025500883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(92)90177-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025535377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90237-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026683952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/361315a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027742268", 
          "https://doi.org/10.1038/361315a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.12.7943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029497594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90438-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029601038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90408-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029739928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90075-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030097485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(94)90038-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031680992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90223-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033067187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/263085a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034197266", 
          "https://doi.org/10.1038/263085a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.8.5192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034611958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-4388(91)90011-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035651421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-4388(91)90011-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035651421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349793a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035801864", 
          "https://doi.org/10.1038/349793a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90401-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035811622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039777366", 
          "https://doi.org/10.1038/363364a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360689a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042782556", 
          "https://doi.org/10.1038/360689a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90324-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043940975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90076-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044188628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353558a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046134030", 
          "https://doi.org/10.1038/353558a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/neu.480250309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048088369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90403-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048207053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3291115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062604905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8396273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076018386", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.10-09-02903.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077297449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.09-02-00507.1989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078927675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079276164", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079575663", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082653634", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-08", 
    "datePublishedReg": "1995-08-01", 
    "description": "The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/376737a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6543", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "376"
      }
    ], 
    "name": "Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions", 
    "pagination": "737-745", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "92293774b771571862f12b3e75c27648a1daab5225293898c35f2d19c28e9d97"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7544443"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/376737a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030681157"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/376737a0", 
      "https://app.dimensions.ai/details/publication/pub.1030681157"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/376737a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/376737a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/376737a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/376737a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/376737a0'


 

This table displays all metadata directly associated to this object as RDF triples.

354 TRIPLES      21 PREDICATES      97 URIs      50 LITERALS      38 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/376737a0 schema:about N0b95cdd263a9425ba36f8d381007141d
2 N0d6bdea52a7a411d83327188230578b7
3 N0de1932424784c44b9bf6b07675816da
4 N181dbaf3dfe1499c9934d45cb18b02ba
5 N22d6b5fb2acb470ca2fad7c5181e91dc
6 N350f30cb27314ffa83449b2ec9e45458
7 N37c37ef1a14b424597e03a6cf5a6bdda
8 N407bb36ee1b0400bb49d0ba23a86467c
9 N4502578cafc94bd18946512af497dc43
10 N4d159315b8e84703823c04c2946552a9
11 N5332caf0fdf14575bf77c3b8cf61cffe
12 N5b2bf763c6984b7fa35129bcbb94f611
13 N62e04f34d4e042b68d098d442418e4b8
14 N722bd6f2bad74cefa345f272573711f9
15 N7822b31f076d4d32949dc32741619170
16 N796f117f104b498b8227a240d5ecb424
17 N79db20fcc4634a9fb9d62e5af5cac7a1
18 N879bc050622b44659829f7455203ea80
19 N9d7449c0882e4f8680360192ab6f656b
20 N9d9b44b5ffde4fc0834a5cb5b5bc9e1c
21 Na069e72a54fd4b17bf9891facc961acd
22 Na0c9383ac9e24fcb90924f16e5b29ddc
23 Nb11c27faf70c485f83131c0336427d86
24 Nbc4910d7ef2a42af8ac1d22186160690
25 Nec7ca43c4bb74682b815d9490d6216f0
26 Nf0f6e1b09218426abca8cebb1f9bf18b
27 Nf3bbb05c9d4647f7847a0094f42703a4
28 Nf56f6d2696df40e4a004ac4f91e8cb78
29 Nf5b16bef523140cc90f9adb7447fe7da
30 anzsrc-for:11
31 anzsrc-for:1109
32 schema:author N7686c6a7c922488cb8a67e72a5ea5b0b
33 schema:citation sg:pub.10.1038/263085a0
34 sg:pub.10.1038/349793a0
35 sg:pub.10.1038/352026b0
36 sg:pub.10.1038/353558a0
37 sg:pub.10.1038/360689a0
38 sg:pub.10.1038/361315a0
39 sg:pub.10.1038/363364a0
40 sg:pub.10.1038/369233a0
41 sg:pub.10.1038/372786a0
42 https://app.dimensions.ai/details/publication/pub.1076018386
43 https://app.dimensions.ai/details/publication/pub.1079276164
44 https://app.dimensions.ai/details/publication/pub.1079575663
45 https://app.dimensions.ai/details/publication/pub.1082653634
46 https://doi.org/10.1002/neu.480250309
47 https://doi.org/10.1016/0092-8674(79)90093-x
48 https://doi.org/10.1016/0092-8674(91)90419-y
49 https://doi.org/10.1016/0092-8674(92)90075-n
50 https://doi.org/10.1016/0092-8674(92)90076-o
51 https://doi.org/10.1016/0092-8674(92)90167-b
52 https://doi.org/10.1016/0092-8674(93)90237-k
53 https://doi.org/10.1016/0092-8674(93)90324-j
54 https://doi.org/10.1016/0092-8674(95)90401-8
55 https://doi.org/10.1016/0092-8674(95)90403-4
56 https://doi.org/10.1016/0092-8674(95)90408-5
57 https://doi.org/10.1016/0304-419x(91)90011-9
58 https://doi.org/10.1016/0896-6273(90)90211-w
59 https://doi.org/10.1016/0896-6273(91)90227-q
60 https://doi.org/10.1016/0896-6273(92)90177-f
61 https://doi.org/10.1016/0896-6273(94)90223-2
62 https://doi.org/10.1016/0896-6273(94)90425-1
63 https://doi.org/10.1016/0896-6273(94)90438-3
64 https://doi.org/10.1016/0959-4388(91)90011-u
65 https://doi.org/10.1016/0968-0004(94)90038-8
66 https://doi.org/10.1126/science.3291115
67 https://doi.org/10.1126/science.8396273
68 https://doi.org/10.1128/mcb.14.12.7943
69 https://doi.org/10.1128/mcb.14.8.5192
70 https://doi.org/10.1523/jneurosci.09-02-00507.1989
71 https://doi.org/10.1523/jneurosci.10-09-02903.1990
72 schema:datePublished 1995-08
73 schema:datePublishedReg 1995-08-01
74 schema:description The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree false
78 schema:isPartOf N5b4fffb18e544f438bb071b5084a6a2d
79 N5dbaff49bb544f61aa33de3607b8e20e
80 sg:journal.1018957
81 schema:name Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions
82 schema:pagination 737-745
83 schema:productId N101e81ac2cd249cb89c9856fce623458
84 N295375a3cc564afd91080cb4b9a13ee5
85 N2f894590d4a8488dbaa6ec38c2ab9308
86 N4bee535c8abc412db0eb364c87ec1503
87 N670a02ee71ea4818926f7303c41f6433
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030681157
89 https://doi.org/10.1038/376737a0
90 schema:sdDatePublished 2019-04-10T17:19
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nf53ec421be5343e083a215f8c391b7b7
93 schema:url http://www.nature.com/articles/376737a0
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0417b487b81245c9858b9bef67153f10 rdf:first N608b3539e37f466ab3b34d30552a9954
98 rdf:rest N537d23833039441fa1468dd14f134587
99 N0b95cdd263a9425ba36f8d381007141d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Tyrosine
101 rdf:type schema:DefinedTerm
102 N0d6bdea52a7a411d83327188230578b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Proteins
104 rdf:type schema:DefinedTerm
105 N0de1932424784c44b9bf6b07675816da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N101e81ac2cd249cb89c9856fce623458 schema:name nlm_unique_id
109 schema:value 0410462
110 rdf:type schema:PropertyValue
111 N181dbaf3dfe1499c9934d45cb18b02ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name DNA Primers
113 rdf:type schema:DefinedTerm
114 N214f33169e5449b99a2e5091fea7b654 rdf:first sg:person.01005455172.89
115 rdf:rest Nf084513338094b8785c937cbec093c5f
116 N22d6b5fb2acb470ca2fad7c5181e91dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Base Sequence
118 rdf:type schema:DefinedTerm
119 N295375a3cc564afd91080cb4b9a13ee5 schema:name readcube_id
120 schema:value 92293774b771571862f12b3e75c27648a1daab5225293898c35f2d19c28e9d97
121 rdf:type schema:PropertyValue
122 N2f894590d4a8488dbaa6ec38c2ab9308 schema:name doi
123 schema:value 10.1038/376737a0
124 rdf:type schema:PropertyValue
125 N305c05cc389d403a8807ca1b5bf281c6 rdf:first sg:person.0777431622.95
126 rdf:rest N0417b487b81245c9858b9bef67153f10
127 N350f30cb27314ffa83449b2ec9e45458 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cells, Cultured
129 rdf:type schema:DefinedTerm
130 N37c37ef1a14b424597e03a6cf5a6bdda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Adaptor Proteins, Signal Transducing
132 rdf:type schema:DefinedTerm
133 N3fb16735499d4c59ae8c5aa47ab1c884 rdf:first sg:person.01176202670.81
134 rdf:rest N443f23e4db2f4eff97a7905104553c05
135 N407bb36ee1b0400bb49d0ba23a86467c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cloning, Molecular
137 rdf:type schema:DefinedTerm
138 N443f23e4db2f4eff97a7905104553c05 rdf:first sg:person.0745044764.20
139 rdf:rest N214f33169e5449b99a2e5091fea7b654
140 N4502578cafc94bd18946512af497dc43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 N4bee535c8abc412db0eb364c87ec1503 schema:name pubmed_id
144 schema:value 7544443
145 rdf:type schema:PropertyValue
146 N4d159315b8e84703823c04c2946552a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Potassium Channels, Voltage-Gated
148 rdf:type schema:DefinedTerm
149 N5332caf0fdf14575bf77c3b8cf61cffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name GRB2 Adaptor Protein
151 rdf:type schema:DefinedTerm
152 N537d23833039441fa1468dd14f134587 rdf:first sg:person.0677266502.40
153 rdf:rest Nf9030d654d624a10adb69d69300627f9
154 N5b2bf763c6984b7fa35129bcbb94f611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Amino Acid Sequence
156 rdf:type schema:DefinedTerm
157 N5b4fffb18e544f438bb071b5084a6a2d schema:volumeNumber 376
158 rdf:type schema:PublicationVolume
159 N5dbaff49bb544f61aa33de3607b8e20e schema:issueNumber 6543
160 rdf:type schema:PublicationIssue
161 N608b3539e37f466ab3b34d30552a9954 schema:familyName Plowman
162 schema:givenName G D
163 rdf:type schema:Person
164 N62e04f34d4e042b68d098d442418e4b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Molecular Sequence Data
166 rdf:type schema:DefinedTerm
167 N670a02ee71ea4818926f7303c41f6433 schema:name dimensions_id
168 schema:value pub.1030681157
169 rdf:type schema:PropertyValue
170 N722bd6f2bad74cefa345f272573711f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 N7686c6a7c922488cb8a67e72a5ea5b0b rdf:first sg:person.01013160164.29
174 rdf:rest N3fb16735499d4c59ae8c5aa47ab1c884
175 N7822b31f076d4d32949dc32741619170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name 3T3 Cells
177 rdf:type schema:DefinedTerm
178 N796f117f104b498b8227a240d5ecb424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name GTP-Binding Proteins
180 rdf:type schema:DefinedTerm
181 N79db20fcc4634a9fb9d62e5af5cac7a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name PC12 Cells
183 rdf:type schema:DefinedTerm
184 N879bc050622b44659829f7455203ea80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Ion Channels
186 rdf:type schema:DefinedTerm
187 N9d7449c0882e4f8680360192ab6f656b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Enzyme Activation
189 rdf:type schema:DefinedTerm
190 N9d9b44b5ffde4fc0834a5cb5b5bc9e1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Calcium
192 rdf:type schema:DefinedTerm
193 Na069e72a54fd4b17bf9891facc961acd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Rats
195 rdf:type schema:DefinedTerm
196 Na0c9383ac9e24fcb90924f16e5b29ddc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Brain
198 rdf:type schema:DefinedTerm
199 Nb11c27faf70c485f83131c0336427d86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Kv1.2 Potassium Channel
201 rdf:type schema:DefinedTerm
202 Nbc4910d7ef2a42af8ac1d22186160690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Protein Kinase C
204 rdf:type schema:DefinedTerm
205 Nec7ca43c4bb74682b815d9490d6216f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Protein-Tyrosine Kinases
207 rdf:type schema:DefinedTerm
208 Nf084513338094b8785c937cbec093c5f rdf:first sg:person.01060417347.88
209 rdf:rest N305c05cc389d403a8807ca1b5bf281c6
210 Nf0f6e1b09218426abca8cebb1f9bf18b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Potassium Channels
212 rdf:type schema:DefinedTerm
213 Nf3bbb05c9d4647f7847a0094f42703a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Protein Kinases
215 rdf:type schema:DefinedTerm
216 Nf53ec421be5343e083a215f8c391b7b7 schema:name Springer Nature - SN SciGraph project
217 rdf:type schema:Organization
218 Nf56f6d2696df40e4a004ac4f91e8cb78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Phosphorylation
220 rdf:type schema:DefinedTerm
221 Nf5b16bef523140cc90f9adb7447fe7da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Focal Adhesion Kinase 2
223 rdf:type schema:DefinedTerm
224 Nf9030d654d624a10adb69d69300627f9 rdf:first sg:person.0745312627.44
225 rdf:rest rdf:nil
226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
227 schema:name Medical and Health Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
230 schema:name Neurosciences
231 rdf:type schema:DefinedTerm
232 sg:journal.1018957 schema:issn 0090-0028
233 1476-4687
234 schema:name Nature
235 rdf:type schema:Periodical
236 sg:person.01005455172.89 schema:familyName Canoll
237 schema:givenName P
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005455172.89
239 rdf:type schema:Person
240 sg:person.01013160164.29 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
241 schema:familyName Lev
242 schema:givenName S
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013160164.29
244 rdf:type schema:Person
245 sg:person.01060417347.88 schema:familyName Peles
246 schema:givenName E
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060417347.88
248 rdf:type schema:Person
249 sg:person.01176202670.81 schema:familyName Moreno
250 schema:givenName H
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176202670.81
252 rdf:type schema:Person
253 sg:person.0677266502.40 schema:familyName Rudy
254 schema:givenName B
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677266502.40
256 rdf:type schema:Person
257 sg:person.0745044764.20 schema:familyName Martinez
258 schema:givenName R
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745044764.20
260 rdf:type schema:Person
261 sg:person.0745312627.44 schema:familyName Schlessinger
262 schema:givenName J
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745312627.44
264 rdf:type schema:Person
265 sg:person.0777431622.95 schema:familyName Musacchio
266 schema:givenName J M
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777431622.95
268 rdf:type schema:Person
269 sg:pub.10.1038/263085a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034197266
270 https://doi.org/10.1038/263085a0
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/349793a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035801864
273 https://doi.org/10.1038/349793a0
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/352026b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019715505
276 https://doi.org/10.1038/352026b0
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/353558a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046134030
279 https://doi.org/10.1038/353558a0
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/360689a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782556
282 https://doi.org/10.1038/360689a0
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/361315a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027742268
285 https://doi.org/10.1038/361315a0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/363364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039777366
288 https://doi.org/10.1038/363364a0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/369233a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013842356
291 https://doi.org/10.1038/369233a0
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/372786a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004642826
294 https://doi.org/10.1038/372786a0
295 rdf:type schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1076018386 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1079276164 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1079575663 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1082653634 schema:CreativeWork
300 https://doi.org/10.1002/neu.480250309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048088369
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/0092-8674(79)90093-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016794939
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/0092-8674(91)90419-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000550070
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/0092-8674(92)90075-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1030097485
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/0092-8674(92)90076-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1044188628
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/0092-8674(92)90167-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1023123401
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0092-8674(93)90237-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1026683952
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/0092-8674(93)90324-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1043940975
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/0092-8674(95)90401-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035811622
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/0092-8674(95)90403-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048207053
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/0092-8674(95)90408-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029739928
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/0304-419x(91)90011-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003526172
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/0896-6273(90)90211-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1025500883
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/0896-6273(91)90227-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1006803577
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/0896-6273(92)90177-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1025535377
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/0896-6273(94)90223-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033067187
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/0896-6273(94)90425-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015574980
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/0896-6273(94)90438-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029601038
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/0959-4388(91)90011-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1035651421
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/0968-0004(94)90038-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031680992
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1126/science.3291115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604905
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1126/science.8396273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654948
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1128/mcb.14.12.7943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029497594
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1128/mcb.14.8.5192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034611958
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1523/jneurosci.09-02-00507.1989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078927675
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1523/jneurosci.10-09-02903.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077297449
351 rdf:type schema:CreativeWork
352 https://www.grid.ac/institutes/grid.240324.3 schema:alternateName New York University Langone Medical Center
353 schema:name Department of Pharmacology, New York University Medical Center, New York 10016, USA.
354 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...