Modulation of memory fields by dopamine Dl receptors in prefrontal cortex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

G V Williams, P S Goldman-Rakic

ABSTRACT

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition. More... »

PAGES

572-575

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/376572a0

DOI

http://dx.doi.org/10.1038/376572a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027841629

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7637804


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