Ontology type: schema:ScholarlyArticle
1995-07
AUTHORSP A Wilson, A Hemmati-Brivanlou
ABSTRACTDuring gastrulation in vertebrates, ectodermal cells choose between two fates, neural and epidermal. The nervous system forms in response to signals from the Spemann organizer; ectoderm that does not receive these signals becomes epidermis. Unexpectedly, however, in Xenopus, neural tissue also forms when cell-cell communication within the ectoderm is disrupted by cell dissociation or by antagonists of the growth factor activin. These observations suggest that epidermal specification depends on local signalling, by activin or a close relative, and that neural tissue forms when this communication is blocked. Here we report that bone morphogenesis protein 4 (Bmp-4), a relative of activin that is expressed in the embryo at the time of ectodermal fate determination, is a potent epidermal inducer and neural inhibitor, the first reported in any vertebrate. Activin can inhibit neuralization by inducing mesoderm, but does not induce epidermis. Moreover, the dominant-negative activin receptor, which stimulates neuralization when expressed in the embryo, blocks Bmp-4 in our assay. Our findings demonstrate that epidermal fate can be induced, and thus provide further evidence that neural specification is under inhibitory control in vertebrates. More... »
PAGES331-333
http://scigraph.springernature.com/pub.10.1038/376331a0
DOIhttp://dx.doi.org/10.1038/376331a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016811156
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7630398
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Activin Receptors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Activins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Morphogenetic Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Culture Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ectoderm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Embryonic Induction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epidermis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follistatin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gastrula",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Growth Substances",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inhibins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neurons",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligodeoxyribonucleotides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Xenopus",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Rockefeller University",
"id": "https://www.grid.ac/institutes/grid.134907.8",
"name": [
"Rockefeller University, New York, New York 10021-6322, USA."
],
"type": "Organization"
},
"familyName": "Wilson",
"givenName": "P A",
"id": "sg:person.01372703623.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372703623.03"
],
"type": "Person"
},
{
"familyName": "Hemmati-Brivanlou",
"givenName": "A",
"id": "sg:person.01351614430.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351614430.72"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0092-8674(91)90573-h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004492987"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0922-3371(89)90006-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013231283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0922-3371(89)90006-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013231283"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/361547a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015936488",
"https://doi.org/10.1038/361547a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90320-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022602688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/359609a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022638232",
"https://doi.org/10.1038/359609a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(92)90514-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034034575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.8.2.133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035926719"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/372677a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041506639",
"https://doi.org/10.1038/372677a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/347391a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043486466",
"https://doi.org/10.1038/347391a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90319-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044553005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.8.8.939",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045043727"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(00)00152-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052445316"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(94)90409-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052539878"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.3945801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062622602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8235591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062653725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2307/1538572",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069529296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5860/choice.26-0295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073286171"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078843140",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082479149",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1994.tb06830.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082582492"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1994.tb06660.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082633107"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082760199",
"type": "CreativeWork"
}
],
"datePublished": "1995-07",
"datePublishedReg": "1995-07-01",
"description": "During gastrulation in vertebrates, ectodermal cells choose between two fates, neural and epidermal. The nervous system forms in response to signals from the Spemann organizer; ectoderm that does not receive these signals becomes epidermis. Unexpectedly, however, in Xenopus, neural tissue also forms when cell-cell communication within the ectoderm is disrupted by cell dissociation or by antagonists of the growth factor activin. These observations suggest that epidermal specification depends on local signalling, by activin or a close relative, and that neural tissue forms when this communication is blocked. Here we report that bone morphogenesis protein 4 (Bmp-4), a relative of activin that is expressed in the embryo at the time of ectodermal fate determination, is a potent epidermal inducer and neural inhibitor, the first reported in any vertebrate. Activin can inhibit neuralization by inducing mesoderm, but does not induce epidermis. Moreover, the dominant-negative activin receptor, which stimulates neuralization when expressed in the embryo, blocks Bmp-4 in our assay. Our findings demonstrate that epidermal fate can be induced, and thus provide further evidence that neural specification is under inhibitory control in vertebrates.",
"genre": "research_article",
"id": "sg:pub.10.1038/376331a0",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "6538",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "376"
}
],
"name": "Induction of epidermis and inhibition of neural fate by Bmp-4",
"pagination": "331-333",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5019360bb3eab7929b7008e3b67dc77efe64502a74b5e64996478b9e03eeef57"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7630398"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/376331a0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016811156"
]
}
],
"sameAs": [
"https://doi.org/10.1038/376331a0",
"https://app.dimensions.ai/details/publication/pub.1016811156"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/376331a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/376331a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/376331a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/376331a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/376331a0'
This table displays all metadata directly associated to this object as RDF triples.
226 TRIPLES
21 PREDICATES
72 URIs
42 LITERALS
30 BLANK NODES