Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

G H Fong, J Rossant, M Gertsenstein, M L Breitman

ABSTRACT

The vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of embryonic vasculature. Here we report that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation. Mouse embryos homozygous for a targeted mutation in the flt-1 locus, flt-1lcz, formed endothelial cells in both embryonic and extra-embryonic regions, but assembled these cells into abnormal vascular channels and died in utero at mid-somite stages. At earlier stages, the blood islands of flt-1lcz homozygotes were abnormal, with angioblasts in the interior as well as on the periphery. We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development. More... »

PAGES

66-70

Journal

TITLE

Nature

ISSUE

6535

VOLUME

376

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/376066a0

    DOI

    http://dx.doi.org/10.1038/376066a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032783732

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7596436


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