Expression of a Delta homologue in prospective neurons in the chick View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Domingos Henrique, Julie Adam, Anna Myat, Ajay Chitnis, Julian Lewis, David Ish-Horowicz

ABSTRACT

THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as receptor, are key components in a lateral-inhibition signalling pathway that regulates the detailed patterning of many different tissues in Drosophila1–8. During neurogenesis in particular, neural precursors, by expressing Delta, inhibit neighbouring Notch-expressing cells from becoming committed to a neural fate5,9,10. Vertebrates are known to have several Notch genes 11–14, but their functions are unclear and their ligands hitherto unidentified. Here we identify and describe a chick Deltahomologue, C-Delta-1. We show that C-Delta-1 is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided. Our data from the chick, combined with parallel evidence fromXenopus15, suggest that both the Delta/ Notch signalling mechanism and its role in neurogenesis have been conserved in vertebrates. More... »

PAGES

787-790

Journal

TITLE

Nature

ISSUE

6534

VOLUME

375

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/375787a0

    DOI

    http://dx.doi.org/10.1038/375787a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048699343

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7596411


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