Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Ajay Chitnis, Domingos Henrique, Julian Lewis, David Ish-Horowicz, Chris Kintner

ABSTRACT

X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the early embryonic nervous system in scattered cells that appear to be the prospective primary neurons. Ectopic X-Delta-1 activity inhibitsproduction of primary neurons and interference with endogenous X-Delta-1 activity results in overproduction of primary neurons. These results indicate that the X-Delta-1 protein mediates lateral inhibition delivered by prospective neurons to adjacent cells, and that commitment to a neural fate in vertebrates is regulated by Delta-Notch signalling as in Drosophila. More... »

PAGES

761-766

Journal

TITLE

Nature

ISSUE

6534

VOLUME

375

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/375761a0

    DOI

    http://dx.doi.org/10.1038/375761a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043670631

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7596407


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